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Gene Review

Akt3  -  v-akt murine thymoma viral oncogene homolog 3

Rattus norvegicus

Synonyms: PKB gamma, Protein kinase Akt-3, Protein kinase B gamma, RAC-PK-gamma, RAC-gamma serine/threonine-protein kinase
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  • Additionally, insulin administration increased the activities of Akt1, Akt2, and Akt3 kinases in calf muscles and caused a sevenfold augmentation in 2-deoxyglucose uptake by these muscles [4].


  1. Contraction regulation of Akt in rat skeletal muscle. Sakamoto, K., Hirshman, M.F., Aschenbach, W.G., Goodyear, L.J. J. Biol. Chem. (2002) [Pubmed]
  2. Extracellular ATP and UTP activate the protein kinase B/Akt cascade via the P2Y(2) purinoceptor in renal mesangial cells. Huwiler, A., Rölz, W., Dorsch, S., Ren, S., Pfeilschifter, J. Br. J. Pharmacol. (2002) [Pubmed]
  3. Molecular cloning and characterization of a new member of the RAC protein kinase family: association of the pleckstrin homology domain of three types of RAC protein kinase with protein kinase C subspecies and beta gamma subunits of G proteins. Konishi, H., Kuroda, S., Tanaka, M., Matsuzaki, H., Ono, Y., Kameyama, K., Haga, T., Kikkawa, U. Biochem. Biophys. Res. Commun. (1995) [Pubmed]
  4. Akt kinases and 2-deoxyglucose uptake in rat skeletal muscles in vivo: study with insulin and exercise. Turinsky, J., Damrau-Abney, A. Am. J. Physiol. (1999) [Pubmed]
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