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Gene Review:

Akt3 - v-akt murine thymoma viral oncogene homolog 3

Rattus norvegicus

Synonyms: PKB gamma, Protein kinase Akt-3, Protein kinase B gamma, RAC-PK-gamma, RAC-gamma serine/threonine-protein kinase

Turinsky, J. et al., Sakamoto, K. et al., Konishi, H. et al., Huwiler, A. et al.

Huwiler, Rölz, Dorsch, Ren, Pfeilschifter,

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High impact information on Akt3

In addition to increasing phosphorylation, contraction in situ significantly increased the activity of all three Akt isoforms (Akt1 > Akt2 > Akt3) with maximal activation occurring at 2.5 min and returning to base line with 15 min of contraction [1].
Western blot analysis of mesangial cells reveals the expression of the isoenzymes PKB-alpha and PKB-gamma, but not the PKB-beta [2].
cDNA clones encoding the third member of the RAC protein kinase family, termed RAC-PK gamma, were isolated from a rat brain cDNA library [3].
Northern blot analysis indicated that RAC-PK gamma was expressed abundantly in brain and testis [3].

Anatomical context of Akt3

Activities of Akt1, Akt2, and Akt3 kinases and glucose uptake in hindlimb muscles of the rat in vivo were investigated [4].

Associations of Akt3 with chemical compounds

Additionally, insulin administration increased the activities of Akt1, Akt2, and Akt3 kinases in calf muscles and caused a sevenfold augmentation in 2-deoxyglucose uptake by these muscles [4].

References

Contraction regulation of Akt in rat skeletal muscle. Sakamoto, K., Hirshman, M.F., Aschenbach, W.G., Goodyear, L.J. J. Biol. Chem. (2002) [Pubmed]
Extracellular ATP and UTP activate the protein kinase B/Akt cascade via the P2Y(2) purinoceptor in renal mesangial cells. Huwiler, A., Rölz, W., Dorsch, S., Ren, S., Pfeilschifter, J. Br. J. Pharmacol. (2002) [Pubmed]
Molecular cloning and characterization of a new member of the RAC protein kinase family: association of the pleckstrin homology domain of three types of RAC protein kinase with protein kinase C subspecies and beta gamma subunits of G proteins. Konishi, H., Kuroda, S., Tanaka, M., Matsuzaki, H., Ono, Y., Kameyama, K., Haga, T., Kikkawa, U. Biochem. Biophys. Res. Commun. (1995) [Pubmed]
Akt kinases and 2-deoxyglucose uptake in rat skeletal muscles in vivo: study with insulin and exercise. Turinsky, J., Damrau-Abney, A. Am. J. Physiol. (1999) [Pubmed]

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AKT3	Bos taurus
AKT3	Canis lupus familiaris
akt3a	Danio rerio
AKT3	Gallus gallus
AKT3	Homo sapiens
AKT3	Macaca mulatta
Akt3	Mus musculus
AKT3	Pan troglodytes

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