Gene Review:
AKT3 - v-akt murine thymoma viral oncogene homolog 3
Homo sapiens
Synonyms:
MPPH, MPPH2, PKB gamma, PKB-GAMMA, PKBG, ...
Zhang,
Zhang,
Yamane,
Wahl,
Ali,
Lofgren,
Kendall,
Stoica,
Franke,
Wellstein,
Czubayko,
List,
Reiter,
Morgan,
Martin,
Stoica,
Barnett,
Defeo-Jones,
Fu,
Hancock,
Haskell,
Jones,
Kahana,
Kral,
Leander,
Lee,
Malinowski,
McAvoy,
Nahas,
Robinson,
Huber,
Noske,
Kaszubiak,
Weichert,
Sers,
Niesporek,
Koch,
Schaefer,
Sehouli,
Dietel,
Lage,
Denkert,
Zhang,
Fang,
Liu,
Wang,
Yang,
- Mutational Analysis of AKT1, AKT2 and AKT3 Genes in Common Human Carcinomas. Soung, Y.H., Lee, J.W., Nam, S.W., Lee, J.Y., Yoo, N.J., Lee, S.H. Oncology (2006)
- The MMAC1 tumor suppressor phosphatase inhibits phospholipase C and integrin-linked kinase activity. Morimoto, A.M., Tomlinson, M.G., Nakatani, K., Bolen, J.B., Roth, R.A., Herbst, R. Oncogene (2000)
- Deregulated Akt3 activity promotes development of malignant melanoma. Stahl, J.M., Sharma, A., Cheung, M., Zimmerman, M., Cheng, J.Q., Bosenberg, M.W., Kester, M., Sandirasegarane, L., Robertson, G.P. Cancer Res. (2004)
- Up-regulation of Akt3 in estrogen receptor-deficient breast cancers and androgen-independent prostate cancer lines. Nakatani, K., Thompson, D.A., Barthel, A., Sakaue, H., Liu, W., Weigel, R.J., Roth, R.A. J. Biol. Chem. (1999)
- Use of human tissue to assess the oncogenic activity of melanoma-associated mutations. Chudnovsky, Y., Adams, A.E., Robbins, P.B., Lin, Q., Khavari, P.A. Nat. Genet. (2005)
- Activation of AKT kinases in cancer: implications for therapeutic targeting. Bellacosa, A., Kumar, C.C., Di Cristofano, A., Testa, J.R. Adv. Cancer Res. (2005)
- A specific role for AKT3 in the genesis of ovarian cancer through modulation of G(2)-M phase transition. Cristiano, B.E., Chan, J.C., Hannan, K.M., Lundie, N.A., Marmy-Conus, N.J., Campbell, I.G., Phillips, W.A., Robbie, M., Hannan, R.D., Pearson, R.B. Cancer Res. (2006)
- Kinetic mechanism of AKT/PKB enzyme family. Zhang, X., Zhang, S., Yamane, H., Wahl, R., Ali, A., Lofgren, J.A., Kendall, R.L. J. Biol. Chem. (2006)
- AKT involvement in cisplatin chemoresistance of human uterine cancer cells. Gagnon, V., Mathieu, I., Sexton, E., Leblanc, K., Asselin, E. Gynecol. Oncol. (2004)
- Inhibition of JNK by cellular stress- and tumor necrosis factor alpha-induced AKT2 through activation of the NF kappa B pathway in human epithelial Cells. Yuan, Z.Q., Feldman, R.I., Sun, M., Olashaw, N.E., Coppola, D., Sussman, G.E., Shelley, S.A., Nicosia, S.V., Cheng, J.Q. J. Biol. Chem. (2002)
- Identification of a human Akt3 (protein kinase B gamma) which contains the regulatory serine phosphorylation site. Nakatani, K., Sakaue, H., Thompson, D.A., Weigel, R.J., Roth, R.A. Biochem. Biophys. Res. Commun. (1999)
- Mapping of AKT3, encoding a member of the Akt/protein kinase B family, to human and rodent chromosomes by fluorescence in situ hybridization. Murthy, S.S., Tosolini, A., Taguchi, T., Testa, J.R. Cytogenet. Cell Genet. (2000)
- Blockade of AKT activation in prostate cancer cells with a small molecule inhibitor, 9-chloro-2-methylellipticinium acetate (CMEP). Zhang, M., Fang, X., Liu, H., Wang, S., Yang, D. Biochem. Pharmacol. (2007)
- Two splice variants of protein kinase B gamma have different regulatory capacity depending on the presence or absence of the regulatory phosphorylation site serine 472 in the carboxyl-terminal hydrophobic domain. Brodbeck, D., Hill, M.M., Hemmings, B.A. J. Biol. Chem. (2001)
- Protein kinase B/Akt is a novel cysteine string protein kinase that regulates exocytosis release kinetics and quantal size. Evans, G.J., Barclay, J.W., Prescott, G.R., Jo, S.R., Burgoyne, R.D., Birnbaum, M.J., Morgan, A. J. Biol. Chem. (2006)
- Estradiol rapidly activates Akt via the ErbB2 signaling pathway. Stoica, G.E., Franke, T.F., Wellstein, A., Czubayko, F., List, H.J., Reiter, R., Morgan, E., Martin, M.B., Stoica, A. Mol. Endocrinol. (2003)
- Akt/protein kinase B isoforms are differentially regulated by epidermal growth factor stimulation. Okano, J., Gaslightwala, I., Birnbaum, M.J., Rustgi, A.K., Nakagawa, H. J. Biol. Chem. (2000)
- Identification and characterization of pleckstrin-homology-domain-dependent and isoenzyme-specific Akt inhibitors. Barnett, S.F., Defeo-Jones, D., Fu, S., Hancock, P.J., Haskell, K.M., Jones, R.E., Kahana, J.A., Kral, A.M., Leander, K., Lee, L.L., Malinowski, J., McAvoy, E.M., Nahas, D.D., Robinson, R.G., Huber, H.E. Biochem. J. (2005)
- Structural and functional complexity of the genomic region controlling AK-toxin biosynthesis and pathogenicity in the Japanese pear pathotype of Alternaria alternata. Tanaka, A., Tsuge, T. Mol. Plant Microbe Interact. (2000)
- Specific inhibition of AKT2 by RNA interference results in reduction of ovarian cancer cell proliferation: Increased expression of AKT in advanced ovarian cancer. Noske, A., Kaszubiak, A., Weichert, W., Sers, C., Niesporek, S., Koch, I., Schaefer, B., Sehouli, J., Dietel, M., Lage, H., Denkert, C. Cancer Lett. (2007)