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Gene Review

Slc26a4  -  solute carrier family 26 (anion exchanger)...

Rattus norvegicus

Synonyms: Pds, Pendrin, Sodium-independent chloride/iodide transporter, Solute carrier family 26 member 4
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Disease relevance of Slc26a4

  • Regulation of the apical Cl-/HCO-3 exchanger pendrin in rat cortical collecting duct in metabolic acidosis [1].
  • In this study, we investigated whether the abundance and subcellular localization of pendrin are regulated in response to experimental metabolic acidosis and alkalosis with maintained water and sodium intake [2].

High impact information on Slc26a4

  • Recent work identified prestin, a protein with similarity to pendrin-related anion transporters, as the OHC motor molecule [3].
  • The purpose of our study was to determine the regulation of Pds protein abundance during chronic changes in chloride balance [4].
  • Conversely, NaCl depletion induced by furosemide was associated with increased Pds expression [4].
  • Here, we examined the regulation of pendrin in metabolic acidosis, a condition known to decrease HCO(3)(-) secretion in CCD [1].
  • These results indicate that changes in pendrin protein expression play a key role in the well-established regulation of HCO(3)(-) secretion in the CCD in response to chronic changes in acid-base balance and suggest that regulation of pendrin expression may be clinically important in the correction of acid-base disturbances [2].

Biological context of Slc26a4


Anatomical context of Slc26a4

  • Northern blot hybridizations indicated that the mRNA expression of pendrin in kidney cortex decreased by 68% in acidotic animals (P < 0.02 vs. control) [1].
  • The anion exchanger pendrin is present in the apical plasma membrane of type B and non-A-non-B intercalated cells of the cortical collecting duct (CCD) and connecting tubule and is involved in HCO(3)(-) secretion [2].
  • The protective effect of I2 was correlated with the highest expression of the I-/Cl- transporter pendrin and with the lowest levels of lipoperoxidation expression in mammary glands [5].

Associations of Slc26a4 with chemical compounds

  • Regulated expression of pendrin in rat kidney in response to chronic NH4Cl or NaHCO3 loading [2].

Analytical, diagnostic and therapeutic context of Slc26a4


  1. Regulation of the apical Cl-/HCO-3 exchanger pendrin in rat cortical collecting duct in metabolic acidosis. Petrovic, S., Wang, Z., Ma, L., Soleimani, M. Am. J. Physiol. Renal Physiol. (2003) [Pubmed]
  2. Regulated expression of pendrin in rat kidney in response to chronic NH4Cl or NaHCO3 loading. Frische, S., Kwon, T.H., Frøkiaer, J., Madsen, K.M., Nielsen, S. Am. J. Physiol. Renal Physiol. (2003) [Pubmed]
  3. Reciprocal electromechanical properties of rat prestin: the motor molecule from rat outer hair cells. Ludwig, J., Oliver, D., Frank, G., Klöcker, N., Gummer, A.W., Fakler, B. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  4. The Cl-/HCO3- exchanger pendrin in the rat kidney is regulated in response to chronic alterations in chloride balance. Quentin, F., Chambrey, R., Trinh-Trang-Tan, M.M., Fysekidis, M., Cambillau, M., Paillard, M., Aronson, P.S., Eladari, D. Am. J. Physiol. Renal Physiol. (2004) [Pubmed]
  5. Inhibition of N-methyl-N-nitrosourea-induced mammary carcinogenesis by molecular iodine (I2) but not by iodide (I-) treatment Evidence that I2 prevents cancer promotion. García-Solís, P., Alfaro, Y., Anguiano, B., Delgado, G., Guzman, R.C., Nandi, S., Díaz-Muñoz, M., Vázquez-Martínez, O., Aceves, C. Mol. Cell. Endocrinol. (2005) [Pubmed]
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