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Gene Review

Slc26a5  -  solute carrier family 26 (anion exchanger)...

Rattus norvegicus

Synonyms: Pres, Prestin, Solute carrier family 26 member 5, prestin
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Disease relevance of Slc26a5


High impact information on Slc26a5


Biological context of Slc26a5

  • Another candidate, "prestin," was identified from a subtracted OHC cDNA library and shown to impart voltage-driven shape changes to transfected cultured cells [5].
  • Prestin gene expression was found at levels of 100 fg specific mRNA/microg total RNA on postnatal day 3, which corresponds to about 300 copies per outer hair cell (OHC) and is indicative of an intermediate level of expression [1].

Anatomical context of Slc26a5

  • Prestin incorporation in the plasma membrane begins from postnatal day 0 and increases progressively in a time course coinciding with that of electromotility [5].
  • To elucidate the variations the prestin mRNA levels undergo as a result of damage to the organ of Corti, we exposed the explant cultures to ischemia and hypoxia [1].

Associations of Slc26a5 with chemical compounds

  • The neutral amino acid alanine replaced serine/threonine at phosphorylation sites to change the conserved phosphorylation motif in order to mimic the dephosphorylated state of prestin, whereas replacement with the negatively charged aspartic acid mimicked the phosphorylated state [3].
  • However, the movements were also diminished by Na salicylate and depended on the intracellular anion, properties implying involvement of the prestin motor [6].
  • Depolarization evoked rapid positive bundle deflections that were reduced by perfusion with the MET channel blocker dihydrostreptomycin, with no effect on the nonlinear capacitance that is a manifestation of prestin-driven somatic motility [6].

Analytical, diagnostic and therapeutic context of Slc26a5

  • The properties of such modified prestin-expressing cells were examined, through measurement of NLC and with confocal microscopy [3].
  • To quantitate in absolute terms the prestin mRNA levels in the explant culture of rat cochlea, we used competitive RT-PCR with a synthetic internal cRNA standard [1].


  1. Expression of prestin mRNA in the organotypic culture of rat cochlea. Gross, J., Machulik, A., Amarjargal, N., Fuchs, J., Mazurek, B. Hear. Res. (2005) [Pubmed]
  2. Reciprocal electromechanical properties of rat prestin: the motor molecule from rat outer hair cells. Ludwig, J., Oliver, D., Frank, G., Klöcker, N., Gummer, A.W., Fakler, B. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  3. Effects of cyclic nucleotides on the function of prestin. Deák, L., Zheng, J., Orem, A., Du, G.G., Aguiñaga, S., Matsuda, K., Dallos, P. J. Physiol. (Lond.) (2005) [Pubmed]
  4. Prestin is expressed on the whole outer hair cell basolateral surface. Yu, N., Zhu, M.L., Zhao, H.B. Brain Res. (2006) [Pubmed]
  5. Expression and localization of prestin and the sugar transporter GLUT-5 during development of electromotility in cochlear outer hair cells. Belyantseva, I.A., Adler, H.J., Curi, R., Frolenkov, G.I., Kachar, B. J. Neurosci. (2000) [Pubmed]
  6. Depolarization of cochlear outer hair cells evokes active hair bundle motion by two mechanisms. Kennedy, H.J., Evans, M.G., Crawford, A.C., Fettiplace, R. J. Neurosci. (2006) [Pubmed]
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