Disease relevance of Notch2

• We isolated recombinant FeLV proviruses encoding feline Notch2 sequences from thymic lymphoma DNA of two cats inoculated with the molecularly cloned virus FeLV-61E [1].
• The product of the FeLV/Notch2 recombinant provirus was a novel, truncated 65- to 70-kD Notch2 protein that was targeted to the cell nucleus [1].
• Transduction of Notch2 in feline leukemia virus-induced thymic lymphoma [1].
• The decrease of both Notch-1 and Notch-2 expression depended on the degree of varicocele development over time, indicating a potential role in varicocele-associated testicular dysfunction [2].

High impact information on Notch2

• Notch 2 was found to be expressed in the non-neuronal derivatives of the optic cup, including the pigment epithelium, optic stalk, and ciliary body [3].
• Notch2: a second mammalian Notch gene [4].
• Each had similar but distinct transduction junctions, and in all cases, the insertions replaced most of the envelope gene with a region of Notch2 that included the intracellular ankyrin repeat functional domain [1].
• Notch 2 is related to both proliferation and maturation of spermatogenic cells, whereas Notch 3 seems to be related to Leydig cell functions [2].
• Varicocele formation diminished the expression of both Notch-1 and Notch-2 receptors as the varicocele formation progressed over time [2].

Anatomical context of Notch2

• Notch2 increased in pulp stroma surrounded by coronal odontoblasts [5].
• Notch-2 expression was present in Leydig cells, spermatogonia, and primary spermatocytes [2].

Other interactions of Notch2

• In several brain areas, Notch1 and Notch2 mRNAs are relatively concentrated in white matter, whereas Notch3 mRNA is not [6].

References