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Gene Review

Notch2  -  notch 2

Rattus norvegicus

Synonyms: Neurogenic locus notch homolog protein 2, Notch 2
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Disease relevance of Notch2


High impact information on Notch2

  • Notch 2 was found to be expressed in the non-neuronal derivatives of the optic cup, including the pigment epithelium, optic stalk, and ciliary body [3].
  • Notch2: a second mammalian Notch gene [4].
  • Each had similar but distinct transduction junctions, and in all cases, the insertions replaced most of the envelope gene with a region of Notch2 that included the intracellular ankyrin repeat functional domain [1].
  • Notch 2 is related to both proliferation and maturation of spermatogenic cells, whereas Notch 3 seems to be related to Leydig cell functions [2].
  • Varicocele formation diminished the expression of both Notch-1 and Notch-2 receptors as the varicocele formation progressed over time [2].

Anatomical context of Notch2


Other interactions of Notch2

  • In several brain areas, Notch1 and Notch2 mRNAs are relatively concentrated in white matter, whereas Notch3 mRNA is not [6].


  1. Transduction of Notch2 in feline leukemia virus-induced thymic lymphoma. Rohn, J.L., Lauring, A.S., Linenberger, M.L., Overbaugh, J. J. Virol. (1996) [Pubmed]
  2. Effect of experimental varicocele on the expressions of Notch 1, 2, and 3 in rat testes: an immunohistochemical study. Sahin, Z., Bayram, Z., Celik-Ozenci, C., Akkoyunlu, G., Seval, Y., Erdogru, T., Ustunel, I., Baykara, M., Demir, R. Fertil. Steril. (2005) [Pubmed]
  3. The expression and function of Notch pathway genes in the developing rat eye. Bao, Z.Z., Cepko, C.L. J. Neurosci. (1997) [Pubmed]
  4. Notch2: a second mammalian Notch gene. Weinmaster, G., Roberts, V.J., Lemke, G. Development (1992) [Pubmed]
  5. Activation of the Notch signaling pathway in response to pulp capping of rat molars. Løvschall, H., Tummers, M., Thesleff, I., Füchtbauer, E.M., Poulsen, K. Eur. J. Oral Sci. (2005) [Pubmed]
  6. Expression patterns of Notch1, Notch2, and Notch3 suggest multiple functional roles for the Notch-DSL signaling system during brain development. Irvin, D.K., Zurcher, S.D., Nguyen, T., Weinmaster, G., Kornblum, H.I. J. Comp. Neurol. (2001) [Pubmed]
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