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Gene Review

Tgfbr2  -  transforming growth factor, beta receptor 2

Rattus norvegicus

Synonyms: TGF-beta 2, TGF-beta receptor type II, TGF-beta receptor type-2, TGF-beta type II receptor, TGFR-2, ...
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Disease relevance of Tgfbr2


High impact information on Tgfbr2


Biological context of Tgfbr2


Anatomical context of Tgfbr2


Associations of Tgfbr2 with chemical compounds


Regulatory relationships of Tgfbr2


Other interactions of Tgfbr2

  • There was also a marked increase in GEC immunostaining for TGF-beta receptor type I (T beta IR) and TGF-beta receptor type II (T beta IIR) at all time points in PHN. mRNA levels for both receptors increased at day 5 [19].
  • AIM: Initial report on the in situ examination of the mRNA expression of transforming growth factor betas (TGFbetas), TGFbeta type II receptor (TbetaRII) and telomerase activity in the experimental rat liver tissue during cholangiocarcinogenesis [20].
  • METHODS AND RESULTS: Overexpression of a kinase-deficient TGFbeta type II receptor (TGFbetaRIIDeltaKD) resulted in a 2.8-fold increase in cardiomyocyte DNA synthesis in serum-rich cultures, an effect requiring active FGFR-1 since it was not observed in the presence of excess kinase-deficient FGFR-1 [21].
  • These observations suggest that the increased expression of the TGF-beta receptor type II via PKC-beta plays an important role in the accelerated proliferation of SMCs under a high glucose condition, leading to the development of diabetic macroangiopathy [17].
  • T beta R-II was more widely distributed in cells than T beta R-III, but T beta R-III was extensively localized in the extracellular matrix [22].

Analytical, diagnostic and therapeutic context of Tgfbr2


  1. Vascular proliferation and transforming growth factor-beta expression in pre- and early stage of diabetes mellitus in Otsuka Long-Evans Tokushima fatty rats. Hosomi, N., Noma, T., Ohyama, H., Takahashi, T., Kohno, M. Atherosclerosis (2002) [Pubmed]
  2. Suppression of in vivo tumorigenicity of rat hepatoma cell line KDH-8 cells by soluble TGF-beta receptor type II. Zhao, W., Kobayashi, M., Ding, W., Yuan, L., Seth, P., Cornain, S., Wang, J., Okada, F., Hosokawa, M. Cancer Immunol. Immunother. (2002) [Pubmed]
  3. Expression of transforming growth factor-beta receptors in normal rat retina and experimental choroidal neovascularization. Yamanaka, R., Ogata, N., Yamamoto, C., Matsushita, M., Matsuzaki, K., Uyama, M., Matsumura, M. Jpn. J. Ophthalmol. (2002) [Pubmed]
  4. Reduction in the expression and action of transforming growth factor beta 1 on lactotropes during estrogen-induced tumorigenesis in the anterior pituitary. Pastorcic, M., De, A., Boyadjieva, N., Vale, W., Sarkar, D.K. Cancer Res. (1995) [Pubmed]
  5. Sphingosine 1-phosphate cross-activates the Smad signaling cascade and mimics transforming growth factor-beta-induced cell responses. Xin, C., Ren, S., Kleuser, B., Shabahang, S., Eberhardt, W., Radeke, H., Schäfer-Korting, M., Pfeilschifter, J., Huwiler, A. J. Biol. Chem. (2004) [Pubmed]
  6. Angiotensin converting enzyme inhibitor suppresses glomerular transforming growth factor beta receptor expression in experimental diabetes in rats. Hill, C., Logan, A., Smith, C., Grønbaek, H., Flyvbjerg, A. Diabetologia (2001) [Pubmed]
  7. Transforming growth factor-beta receptor and fibronectin expressions in aortic smooth muscle cells in diabetic rats. Kanzaki, T., Shiina, R., Saito, Y., Zardi, L., Morisaki, N. Diabetologia (1997) [Pubmed]
  8. Autonomic neurogenesis and apoptosis are alternative fates of progenitor cell communities induced by TGFbeta. Hagedorn, L., Floris, J., Suter, U., Sommer, L. Dev. Biol. (2000) [Pubmed]
  9. Molecular characterization of rat transforming growth factor-beta type II receptor. Tsuchida, K., Lewis, K.A., Mathews, L.S., Vale, W.W. Biochem. Biophys. Res. Commun. (1993) [Pubmed]
  10. Expression of transforming growth factor (TGF)-beta1 and TGF-beta type II receptor in preneoplastic lesions during chemical hepatocarcinogenesis of rats. Park, D.Y., Hwang, S.Y., Suh, K.S. Toxicologic pathology. (2001) [Pubmed]
  11. Effect of substance P on gene expression of transforming growth factor beta-1 and its receptors in rat's fibroblasts. Lai, X.N., Wang, Z.G., Zhu, J.M., Wang, L.L. Chinese journal of traumatology = Zhonghua chuang shang za zhi / Chinese Medical Association. (2003) [Pubmed]
  12. Stimulation of pro-alpha(1)(I) collagen by TGF-beta(1) in mesangial cells: role of the p38 MAPK pathway. Chin, B.Y., Mohsenin, A., Li, S.X., Choi, A.M., Choi, M.E. Am. J. Physiol. Renal Physiol. (2001) [Pubmed]
  13. TGF-beta type II receptor in rat renal vascular development: localization to juxtaglomerular cells. Liu, A., Ballermann, B.J. Kidney Int. (1998) [Pubmed]
  14. Dopamine, dopamine D2 receptor short isoform, transforming growth factor (TGF)-beta1, and TGF-beta type II receptor interact to inhibit the growth of pituitary lactotropes. Sarkar, D.K., Chaturvedi, K., Oomizu, S., Boyadjieva, N.I., Chen, C.P. Endocrinology (2005) [Pubmed]
  15. Curcumin blocks multiple sites of the TGF-beta signaling cascade in renal cells. Gaedeke, J., Noble, N.A., Border, W.A. Kidney Int. (2004) [Pubmed]
  16. Developmental regulation of the serotonergic transmitter phenotype in rostral and caudal raphe neurons by transforming growth factor-betas. Galter, D., Böttner, M., Unsicker, K. J. Neurosci. Res. (1999) [Pubmed]
  17. Role of PKC and TGF-beta receptor in glucose-induced proliferation of smooth muscle cells. Yasuda, Y., Nakamura, J., Hamada, Y., Nakayama, M., Chaya, S., Naruse, K., Nakashima, E., Kato, K., Kamiya, H., Hotta, N. Biochem. Biophys. Res. Commun. (2001) [Pubmed]
  18. Molecular mechanisms of the exaggerated growth of vascular smooth muscle cells in hypertension. Fukuda, N. J. Atheroscler. Thromb. (1997) [Pubmed]
  19. Differential expression of transforming growth factor-beta isoforms and receptors in experimental membranous nephropathy. Shankland, S.J., Pippin, J., Pichler, R.H., Gordon, K.L., Friedman, S., Gold, L.I., Johnson, R.J., Couser, W.G. Kidney Int. (1996) [Pubmed]
  20. In situ detection of TGF betas, TGF beta receptor II mRNA and telomerase activity in rat cholangiocarcinogenesis. Lu, J.P., Mao, J.Q., Li, M.S., Lu, S.L., Hu, X.Q., Zhu, S.N., Nomura, S. World J. Gastroenterol. (2003) [Pubmed]
  21. Inhibition of TGFbeta signaling potentiates the FGF-2-induced stimulation of cardiomyocyte DNA synthesis. Sheikh, F., Hirst, C.J., Jin, Y., Bock, M.E., Fandrich, R.R., Nickel, B.E., Doble, B.W., Kardami, E., Cattini, P.A. Cardiovasc. Res. (2004) [Pubmed]
  22. Expression of transforming growth factor-beta receptors types II and III within various cells in the rat periodontium. Gao, J., Symons, A.L., Bartold, P.M. J. Periodont. Res. (1999) [Pubmed]
  23. Expression of TGF-beta superfamily receptors in dental pulp. Toyono, T., Nakashima, M., Kuhara, S., Akamine, A. J. Dent. Res. (1997) [Pubmed]
  24. Transforming growth factor-beta receptor types I and II are expressed in renal tubules and are increased after chronic unilateral ureteral obstruction. Sutaria, P.M., Ohebshalom, M., McCaffrey, T.A., Vaughan, E.D., Felsen, D. Life Sci. (1998) [Pubmed]
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