The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Links

 

Gene Review

Bcar3  -  breast cancer anti-estrogen resistance 3

Mus musculus

Synonyms: AI131758, AND-34, And34, Breast cancer anti-estrogen resistance protein 3, p130Cas-binding protein AND-34
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

High impact information on Bcar3

  • Synergistic promotion of c-Src activation and cell migration by Cas and AND-34/BCAR3 [1].
  • Consistent with this, a subpopulation of AND-34 overexpressing B cells have long filamentous actin-containing cellular extensions [2].
  • The carboxyl-terminal guanine nucleotide exchange factor domain of AND-34, as well as the activity of its putative target Rap1, contribute to these events [1].
  • As previously reported for lymphoid cells transfected with constitutively active Cdc42, AND-34 overexpression inhibits SDF-1alpha-induced B cell polarization [2].
  • Efficient binding to AND-34 required both the Src-binding domain and a flanking carboxyl-terminal region of p130(Cas) [3].
 

Biological context of Bcar3

  • Fifteen minutes of serum stimulation of vanadate-pretreated AND-34-1-transfected NIH3T3 fibroblasts induces tyrosine phosphorylation of AND-34 as well as coprecipitating 95-, 125-, and 130-kDa proteins [4].
  • Anti-CD3 epsilon treatment induces up-regulation of the AND-34 mRNA levels in total thymic RNA but not in RNA from purified thymocytes, suggesting that this transcript is derived from a thymic stromal cell population [4].
 

Anatomical context of Bcar3

  • IL-1 and TNF increase AND-34 transcript levels in thymic cortical reticular, thymic nurse, and fibroblast cell lines [4].
  • AND-34, a novel p130Cas-binding thymic stromal cell protein regulated by adhesion and inflammatory cytokines [4].
  • In the thymic cortical reticular cell line, IL-1 and TNF induce a protein of the predicted 93-kDa size reactive with anti-AND-34 peptide antisera [4].
 

Associations of Bcar3 with chemical compounds

References

  1. Synergistic promotion of c-Src activation and cell migration by Cas and AND-34/BCAR3. Riggins, R.B., Quilliam, L.A., Bouton, A.H. J. Biol. Chem. (2003) [Pubmed]
  2. The GDP exchange factor AND-34 is expressed in B cells, associates with HEF1, and activates Cdc42. Cai, D., Felekkis, K.N., Near, R.I., O'Neill, G.M., van Seventer, J.M., Golemis, E.A., Lerner, A. J. Immunol. (2003) [Pubmed]
  3. p130Cas regulates the activity of AND-34, a novel Ral, Rap1, and R-Ras guanine nucleotide exchange factor. Gotoh, T., Cai, D., Tian, X., Feig, L.A., Lerner, A. J. Biol. Chem. (2000) [Pubmed]
  4. AND-34, a novel p130Cas-binding thymic stromal cell protein regulated by adhesion and inflammatory cytokines. Cai, D., Clayton, L.K., Smolyar, A., Lerner, A. J. Immunol. (1999) [Pubmed]
 
WikiGenes - Universities