Gene Review:
Bcar1 - breast cancer anti-estrogen resistance 1
Mus musculus
Synonyms:
AI385681, Breast cancer anti-estrogen resistance protein 1, CRK-associated substrate, Cas, Crkas, ...
- Cardiovascular anomaly, impaired actin bundling and resistance to Src-induced transformation in mice lacking p130Cas. Honda, H., Oda, H., Nakamoto, T., Honda, Z., Sakai, R., Suzuki, T., Saito, T., Nakamura, K., Nakao, K., Ishikawa, T., Katsuki, M., Yazaki, Y., Hirai, H. Nat. Genet. (1998)
- Crk-associated substrate tyrosine phosphorylation sites are critical for invasion and metastasis of SRC-transformed cells. Brábek, J., Constancio, S.S., Siesser, P.F., Shin, N.Y., Pozzi, A., Hanks, S.K. Mol. Cancer Res. (2005)
- Agonist-stimulated cytoskeletal reorganization and signal transduction at focal adhesions in vascular smooth muscle cells require c-Src. Ishida, T., Ishida, M., Suero, J., Takahashi, M., Berk, B.C. J. Clin. Invest. (1999)
- ROCK and mDia1 antagonize in Rho-dependent Rac activation in Swiss 3T3 fibroblasts. Tsuji, T., Ishizaki, T., Okamoto, M., Higashida, C., Kimura, K., Furuyashiki, T., Arakawa, Y., Birge, R.B., Nakamoto, T., Hirai, H., Narumiya, S. J. Cell Biol. (2002)
- Interaction between focal adhesion kinase and Crk-associated tyrosine kinase substrate p130Cas. Polte, T.R., Hanks, S.K. Proc. Natl. Acad. Sci. U.S.A. (1995)
- The docking protein Cas links tyrosine phosphorylation signaling to elongation of cerebellar granule cell axons. Huang, J., Sakai, R., Furuichi, T. Mol. Biol. Cell (2006)
- Stable association of PYK2 and p130(Cas) in osteoclasts and their co-localization in the sealing zone. Lakkakorpi, P.T., Nakamura, I., Nagy, R.M., Parsons, J.T., Rodan, G.A., Duong, L.T. J. Biol. Chem. (1999)
- Src kinase plays an essential role in integrin-mediated tyrosine phosphorylation of Crk-associated substrate p130Cas. Hamasaki, K., Mimura, T., Morino, N., Furuya, H., Nakamoto, T., Aizawa, S., Morimoto, C., Yazaki, Y., Hirai, H., Nojima, Y. Biochem. Biophys. Res. Commun. (1996)
- Requirements for localization of p130cas to focal adhesions. Nakamoto, T., Sakai, R., Honda, H., Ogawa, S., Ueno, H., Suzuki, T., Aizawa, S., Yazaki, Y., Hirai, H. Mol. Cell. Biol. (1997)
- CAS promotes invasiveness of Src-transformed cells. Brábek, J., Constancio, S.S., Shin, N.Y., Pozzi, A., Weaver, A.M., Hanks, S.K. Oncogene (2004)
- Subsets of the major tyrosine phosphorylation sites in Crk-associated substrate (CAS) are sufficient to promote cell migration. Shin, N.Y., Dise, R.S., Schneider-Mergener, J., Ritchie, M.D., Kilkenny, D.M., Hanks, S.K. J. Biol. Chem. (2004)
- Protein phosphatase 2A interacts with the Src kinase substrate p130(CAS). Yokoyama, N., Miller, W.T. Oncogene (2001)
- Novel function of Chat in controlling cell adhesion via Cas-Crk-C3G-pathway-mediated Rap1 activation. Sakakibara, A., Ohba, Y., Kurokawa, K., Matsuda, M., Hattori, S. J. Cell. Sci. (2002)
- Src phosphorylates Cas on tyrosine 253 to promote migration of transformed cells. Goldberg, G.S., Alexander, D.B., Pellicena, P., Zhang, Z.Y., Tsuda, H., Miller, W.T. J. Biol. Chem. (2003)
- Blockade of v-Src-stimulated tumor formation by the Src homology 3 domain of Crk-associated substrate (Cas). Cheng, C.H., Yu, K.C., Chen, H.L., Chen, S.Y., Huang, C.H., Chan, P.C., Wung, C.W., Chen, H.C. FEBS Lett. (2004)
- c-Src-mediated phosphorylation of TRIP6 regulates its function in lysophosphatidic acid-induced cell migration. Lai, Y.J., Chen, C.S., Lin, W.C., Lin, F.T. Mol. Cell. Biol. (2005)
- Fluoroaluminate stimulates phosphorylation of p130 Cas and Fak and increases attachment and spreading of preosteoblastic MC3T3-E1 cells. Freitas, F., Jeschke, M., Majstorovic, I., Mueller, D.R., Schindler, P., Voshol, H., Van Oostrum, J., Susa, M. Bone (2002)
- Differential regulation of cell migration and cell cycle progression by FAK complexes with Src, PI3K, Grb7 and Grb2 in focal contacts. Shen, T.L., Guan, J.L. FEBS Lett. (2001)
- Essential function of PTP-PEST during mouse embryonic vascularization, mesenchyme formation, neurogenesis and early liver development. Sirois, J., C??t??, J.F., Charest, A., Uetani, N., Bourdeau, A., Duncan, S.A., Daniels, E., Tremblay, M.L. Mech. Dev. (2006)
- Requirement of Nck adaptors for actin dynamics and cell migration stimulated by platelet-derived growth factor B. Rivera, G.M., Antoku, S., Gelkop, S., Shin, N.Y., Hanks, S.K., Pawson, T., Mayer, B.J. Proc. Natl. Acad. Sci. U.S.A. (2006)
- SRC utilizes Cas to block gap junctional communication mediated by connexin43. Shen, Y., Khusial, P.R., Li, X., Ichikawa, H., Moreno, A.P., Goldberg, G.S. J. Biol. Chem. (2007)
- Tyrosine phosphorylation of p130Cas is involved in actin organization in osteoclasts. Nakamura, I., Jimi, E., Duong, L.T., Sasaki, T., Takahashi, N., Rodan, G.A., Suda, T. J. Biol. Chem. (1998)