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Gene Review

Bcar1  -  breast cancer anti-estrogen resistance 1

Mus musculus

Synonyms: AI385681, Breast cancer anti-estrogen resistance protein 1, CRK-associated substrate, Cas, Crkas, ...
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Disease relevance of Bcar1


High impact information on Bcar1

  • Moreover, expression of activated Src in Cas-deficient primary fibroblasts did not induce a fully transformed phenotype, possibly owing to insufficient accumulation of actin cytoskeleton in podosomes [1].
  • In addition, actin stress fiber formation was severely impaired in Cas-deficient primary fibroblasts [1].
  • p130Cas (Cas), the protein encoded by the Crkas gene (also known as Cas), is an adaptor molecule with a unique structure that contains a Src homology (SH)-3 domain followed by multiple YXXP motifs and a proline-rich region [1].
  • Tyrosine phosphorylation of Cas, paxillin, and tensin were markedly decreased in VSMCs expressing KI-Src and in src-/- VSMCs [3].
  • Thus, these results have revealed the Rho-dependent Rac activation signaling that is mediated by mDia1 through Cas phosphorylation and antagonized by the action of ROCK [4].

Biological context of Bcar1

  • The screen identified two proteins that interact with FAK via their Src homology 3 (SH3) domains: a v-Crk-associated tyrosine kinase substrate (Cas), p130Cas, and a still uncharacterized protein, FIPSH3-2, which contains an SH3 domain closely related to that of p130Cas [5].
  • These findings demonstrate that Cas acts as a key scaffold that links the proteins associated with tyrosine phosphorylation signaling pathways to the granule cell axon elongation [6].
  • Crk-associated substrate (Cas) is a tyrosine-phosphorylated docking protein that is indispensable for the regulation of the actin cytoskeletal organization and cell migration in fibroblasts [6].
  • Cas coimmunoprecipitates with Src family protein tyrosine kinases, Crk, and cell adhesion molecules and colocalizes with these proteins in granule cells [6].
  • The axon extension of granule cells is inhibited by either RNA interference knockdown of Cas or overexpression of the Cas mutant lacking the YDxP motifs, which are tyrosine phosphorylated and thereby interact with Crk [6].

Anatomical context of Bcar1


Associations of Bcar1 with chemical compounds


Enzymatic interactions of Bcar1


Regulatory relationships of Bcar1

  • In this study, we found that the Src homology (SH) 3 domain of Cas blocked v-Src-stimulated anchorage-independent cell growth, Matrigel invasion, and tumor growth in nude mice [15].
  • However, it abolishes the association of TRIP6 with Crk and p130cas in cells and significantly reduces the function of TRIP6 to promote LPA-induced ERK activation [16].

Other interactions of Bcar1


Analytical, diagnostic and therapeutic context of Bcar1


  1. Cardiovascular anomaly, impaired actin bundling and resistance to Src-induced transformation in mice lacking p130Cas. Honda, H., Oda, H., Nakamoto, T., Honda, Z., Sakai, R., Suzuki, T., Saito, T., Nakamura, K., Nakao, K., Ishikawa, T., Katsuki, M., Yazaki, Y., Hirai, H. Nat. Genet. (1998) [Pubmed]
  2. Crk-associated substrate tyrosine phosphorylation sites are critical for invasion and metastasis of SRC-transformed cells. Brábek, J., Constancio, S.S., Siesser, P.F., Shin, N.Y., Pozzi, A., Hanks, S.K. Mol. Cancer Res. (2005) [Pubmed]
  3. Agonist-stimulated cytoskeletal reorganization and signal transduction at focal adhesions in vascular smooth muscle cells require c-Src. Ishida, T., Ishida, M., Suero, J., Takahashi, M., Berk, B.C. J. Clin. Invest. (1999) [Pubmed]
  4. ROCK and mDia1 antagonize in Rho-dependent Rac activation in Swiss 3T3 fibroblasts. Tsuji, T., Ishizaki, T., Okamoto, M., Higashida, C., Kimura, K., Furuyashiki, T., Arakawa, Y., Birge, R.B., Nakamoto, T., Hirai, H., Narumiya, S. J. Cell Biol. (2002) [Pubmed]
  5. Interaction between focal adhesion kinase and Crk-associated tyrosine kinase substrate p130Cas. Polte, T.R., Hanks, S.K. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  6. The docking protein Cas links tyrosine phosphorylation signaling to elongation of cerebellar granule cell axons. Huang, J., Sakai, R., Furuichi, T. Mol. Biol. Cell (2006) [Pubmed]
  7. Stable association of PYK2 and p130(Cas) in osteoclasts and their co-localization in the sealing zone. Lakkakorpi, P.T., Nakamura, I., Nagy, R.M., Parsons, J.T., Rodan, G.A., Duong, L.T. J. Biol. Chem. (1999) [Pubmed]
  8. Src kinase plays an essential role in integrin-mediated tyrosine phosphorylation of Crk-associated substrate p130Cas. Hamasaki, K., Mimura, T., Morino, N., Furuya, H., Nakamoto, T., Aizawa, S., Morimoto, C., Yazaki, Y., Hirai, H., Nojima, Y. Biochem. Biophys. Res. Commun. (1996) [Pubmed]
  9. Requirements for localization of p130cas to focal adhesions. Nakamoto, T., Sakai, R., Honda, H., Ogawa, S., Ueno, H., Suzuki, T., Aizawa, S., Yazaki, Y., Hirai, H. Mol. Cell. Biol. (1997) [Pubmed]
  10. CAS promotes invasiveness of Src-transformed cells. Brábek, J., Constancio, S.S., Shin, N.Y., Pozzi, A., Weaver, A.M., Hanks, S.K. Oncogene (2004) [Pubmed]
  11. Subsets of the major tyrosine phosphorylation sites in Crk-associated substrate (CAS) are sufficient to promote cell migration. Shin, N.Y., Dise, R.S., Schneider-Mergener, J., Ritchie, M.D., Kilkenny, D.M., Hanks, S.K. J. Biol. Chem. (2004) [Pubmed]
  12. Protein phosphatase 2A interacts with the Src kinase substrate p130(CAS). Yokoyama, N., Miller, W.T. Oncogene (2001) [Pubmed]
  13. Novel function of Chat in controlling cell adhesion via Cas-Crk-C3G-pathway-mediated Rap1 activation. Sakakibara, A., Ohba, Y., Kurokawa, K., Matsuda, M., Hattori, S. J. Cell. Sci. (2002) [Pubmed]
  14. Src phosphorylates Cas on tyrosine 253 to promote migration of transformed cells. Goldberg, G.S., Alexander, D.B., Pellicena, P., Zhang, Z.Y., Tsuda, H., Miller, W.T. J. Biol. Chem. (2003) [Pubmed]
  15. Blockade of v-Src-stimulated tumor formation by the Src homology 3 domain of Crk-associated substrate (Cas). Cheng, C.H., Yu, K.C., Chen, H.L., Chen, S.Y., Huang, C.H., Chan, P.C., Wung, C.W., Chen, H.C. FEBS Lett. (2004) [Pubmed]
  16. c-Src-mediated phosphorylation of TRIP6 regulates its function in lysophosphatidic acid-induced cell migration. Lai, Y.J., Chen, C.S., Lin, W.C., Lin, F.T. Mol. Cell. Biol. (2005) [Pubmed]
  17. Fluoroaluminate stimulates phosphorylation of p130 Cas and Fak and increases attachment and spreading of preosteoblastic MC3T3-E1 cells. Freitas, F., Jeschke, M., Majstorovic, I., Mueller, D.R., Schindler, P., Voshol, H., Van Oostrum, J., Susa, M. Bone (2002) [Pubmed]
  18. Differential regulation of cell migration and cell cycle progression by FAK complexes with Src, PI3K, Grb7 and Grb2 in focal contacts. Shen, T.L., Guan, J.L. FEBS Lett. (2001) [Pubmed]
  19. Essential function of PTP-PEST during mouse embryonic vascularization, mesenchyme formation, neurogenesis and early liver development. Sirois, J., C??t??, J.F., Charest, A., Uetani, N., Bourdeau, A., Duncan, S.A., Daniels, E., Tremblay, M.L. Mech. Dev. (2006) [Pubmed]
  20. Requirement of Nck adaptors for actin dynamics and cell migration stimulated by platelet-derived growth factor B. Rivera, G.M., Antoku, S., Gelkop, S., Shin, N.Y., Hanks, S.K., Pawson, T., Mayer, B.J. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  21. SRC utilizes Cas to block gap junctional communication mediated by connexin43. Shen, Y., Khusial, P.R., Li, X., Ichikawa, H., Moreno, A.P., Goldberg, G.S. J. Biol. Chem. (2007) [Pubmed]
  22. Tyrosine phosphorylation of p130Cas is involved in actin organization in osteoclasts. Nakamura, I., Jimi, E., Duong, L.T., Sasaki, T., Takahashi, N., Rodan, G.A., Suda, T. J. Biol. Chem. (1998) [Pubmed]
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