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Gene Review

GUCY1A3  -  guanylate cyclase 1, soluble, alpha 3

Homo sapiens

Synonyms: GC-SA3, GCS-alpha-1, GCS-alpha-3, GUC1A3, GUCA3, ...
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Disease relevance of GUCY1A3


High impact information on GUCY1A3

  • Furthermore, subcutaneous tumor formation by U-87MG cells in nude mice was dramatically suppressed to less than 0.05% in volume by transfection of either antisense GUCY1A3 or antisense GUCY1B3, which was accompanied by the significant decrease in vascular index to about 10% [1].
  • Transfection of antisense GUCY1A3 or GUCY1B3 into these two glioma cell lines markedly reduced the content of cGMP and expression of VEGF [1].
  • One gene, guanylate cyclase 1 alpha 3 (GUCY1A3), showed differential expression between the 1 week and maternally reared groups and the 1 week and 1 month groups; these changes were confirmed by in situ hybridization [3].
  • Additional in situ hybridization studies of GUCY1A3 in normal monkeys showed that this gene is expressed at adult levels by 1 week of age and that its expression is greater in the amygdala than all other brain areas examined [3].
  • We conclude that GUCY1A3 may contribute to the altered behavioral phenotypes that are differentially displayed depending on the age at which macaque infants experience an early-life stress [3].

Chemical compound and disease context of GUCY1A3


  1. Inhibition of angiogenesis in human glioma cell lines by antisense RNA from the soluble guanylate cyclase genes, GUCY1A3 and GUCY1B3. Saino, M., Maruyama, T., Sekiya, T., Kayama, T., Murakami, Y. Oncol. Rep. (2004) [Pubmed]
  2. Assignment of GUCY1A3, a candidate gene for hypertension, to human chromosome bands 4q31.1-->q31.2 by in situ hybridization. Behrends, S., Vehse, K., Scholz, H., Bullerdiek, J., Kazmierczak, B. Cytogenet. Cell Genet. (2000) [Pubmed]
  3. Amygdala gene expression correlates of social behavior in monkeys experiencing maternal separation. Sabatini, M.J., Ebert, P., Lewis, D.A., Levitt, P., Cameron, J.L., Mirnics, K. J. Neurosci. (2007) [Pubmed]
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