High impact information on SNX15

• Identification and characterization of SNX15, a novel sorting nexin involved in protein trafficking [1].
• Based on our data and the existing findings with yeast orthologs of other sorting nexins, we propose that overexpression of SNX15 disrupts the normal trafficking of proteins from the plasma membrane to recycling endosomes or the trans-Golgi network [1].
• Although predicted to be a soluble protein, both endogenous and overexpressed SNX15 are found on membranes and in the cytosol [1].
• However, overexpression of SNX15 led to a decrease in the processing of insulin and hepatocyte growth factor receptors to their mature subunits [1].
• Overexpression of a novel sorting nexin, SNX15, affects endosome morphology and protein trafficking [2].

Biological context of SNX15

• In transient transfection experiments, myc-SNX15 was first seen in small punctate spots and small ring structures [2].
• In myc-SNX15-overexpressing cells, the endocytosis of transferrin was severely inhibited and endocytosis of tac-trans-Golgi network (TGN) 38 and tac-furin was slowed [2].

Anatomical context of SNX15

• Overexpression of myc-tagged SNX15 in COS-7 cells altered the morphology of several endosomal compartments [2].
• However, the morphology of the endoplasmic reticulum and Golgi was not affected by overexpression of myc-SNX15 [2].

Analytical, diagnostic and therapeutic context of SNX15

• By Northern blot analysis, SNX15 mRNA is widely expressed [1].

References