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Gene Review

hhex  -  hematopoietically expressed homeobox

Danio rerio

Synonyms: Hematopoietically-expressed homeobox protein hhex, Homeobox protein hex, SO:0000704, hex
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High impact information on hhex

  • However, analysis of a hhex deficiency allele shows that hhex is not essential for early endothelial and blood differentiation, suggesting that another gene, perhaps scl, compensates for the absence of Hhex function [1].
  • Further, we show that the boz-mediated induction of hhex is independent of the Boz-mediated repression of bmp2b [2].
  • In zebrafish, Nieuwkoop-center-like activity resides in the dorsal yolk syncytial layer (YSL) at the interface of the vegetal yolk cell and the blastoderm. hex homologs are expressed in the anterior endomesoderm in frogs (Xhex), the anterior visceral endoderm in mice, and the dorsal YSL in zebrafish (hhex) [2].
  • During zebrafish development, the thyroid primordium initiates expression of molecular markers such as hhex and nk2.1a in the endoderm prior to pharynx formation [3].
  • In zebrafish, the onset of liver specification is marked by the localized endodermal expression of hhex and prox1 at 22 hours post fertilization [4].

Biological context of hhex


Other interactions of hhex

  • Furthermore, we find that hhex and scl can induce each other's expression, suggesting that these two genes cross-regulate each other during early endothelial and blood differentiation [1].


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