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Gene Review

HHEX  -  hematopoietically expressed homeobox

Homo sapiens

Synonyms: HEX, HMPH, HOX11L-PEN, Hematopoietically-expressed homeobox protein HHEX, Homeobox protein HEX, ...
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High impact information on HHEX

  • Through this interaction, PRH inhibits eIF4E-dependent mRNA transport and subsequent transformation [1].
  • Two candidate enhancers discovered in this way were located in intron 1 of the Fli-1 and PRH/Hex genes, both transcription factors previously implicated in controlling blood and endothelial development [2].
  • Here we demonstrate that the proline-rich N-terminal domain of PRH binds to TLE1 in vitro and in yeast two-hybrid assays [3].
  • Finally, we show that a mutation in the PRH N-terminal domain that blocks the PRH-TLE1 interaction in vitro eliminates co-repression [3].
  • The proline-rich homeodomain protein (PRH/Hex) is important in the control of cell proliferation and differentiation and in the regulation of multiple processes in embryonic development [3].

Biological context of HHEX

  • Genomic organization and chromosome mapping of the human homeobox gene HHEX [4].
  • We discuss these results in terms of the roles of PRH and TLE in cell differentiation and development [3].
  • The PRH homeodomain represses transcription by binding to TATA box sequences, whereas the proline-rich N-terminal domain of PRH can repress transcription when attached to a heterologous DNA-binding domain [3].
  • Within the first region of deletion at 10q23.33-10q24.1, around microsatellite marker D10S185 (2.77 Mb), 23 genes were identified, including three (KIF11, HHEX, and HELLS) with functions that, if dysregulated, could be critical in MF and SS [5].
  • We discuss these findings in terms of the biological role of PRH in gene regulation and the control of cell proliferation [6].

Anatomical context of HHEX


Associations of HHEX with chemical compounds


Other interactions of HHEX

  • In the present study, we report the genomic reconstruction of the human homeobox-containing gene HHEX by the use of the data available in public databases [4].

Analytical, diagnostic and therapeutic context of HHEX


  1. The proline-rich homeodomain protein, PRH, is a tissue-specific inhibitor of eIF4E-dependent cyclin D1 mRNA transport and growth. Topisirovic, I., Culjkovic, B., Cohen, N., Perez, J.M., Skrabanek, L., Borden, K.L. EMBO J. (2003) [Pubmed]
  2. Genome-wide identification of cis-regulatory sequences controlling blood and endothelial development. Donaldson, I.J., Chapman, M., Kinston, S., Landry, J.R., Knezevic, K., Piltz, S., Buckley, N., Green, A.R., Göttgens, B. Hum. Mol. Genet. (2005) [Pubmed]
  3. The proline-rich homeodomain protein recruits members of the Groucho/Transducin-like enhancer of split protein family to co-repress transcription in hematopoietic cells. Swingler, T.E., Bess, K.L., Yao, J., Stifani, S., Jayaraman, P.S. J. Biol. Chem. (2004) [Pubmed]
  4. Genomic organization and chromosome mapping of the human homeobox gene HHEX. Morgutti, M., Demori, E., Pecile, V., Amoroso, A., Rustighi, A., Manfioletti, G. Cytogenet. Cell Genet. (2001) [Pubmed]
  5. Fine mapping of chromosome 10q deletions in mycosis fungoides and sezary syndrome: identification of two discrete regions of deletion at 10q23.33-24.1 and 10q24.33-25.1. Wain, E.M., Mitchell, T.J., Russell-Jones, R., Whittaker, S.J. Genes Chromosomes Cancer (2005) [Pubmed]
  6. The transcriptional repressor protein PRH interacts with the proteasome. Bess, K.L., Swingler, T.E., Rivett, A.J., Gaston, K., Jayaraman, P.S. Biochem. J. (2003) [Pubmed]
  7. Interaction between hex and GATA transcription factors in vascular endothelial cells inhibits flk-1/KDR-mediated vascular endothelial growth factor signaling. Minami, T., Murakami, T., Horiuchi, K., Miura, M., Noguchi, T., Miyazaki, J., Hamakubo, T., Aird, W.C., Kodama, T. J. Biol. Chem. (2004) [Pubmed]
  8. PCR cloning of an orphan homeobox gene (PRH) preferentially expressed in myeloid and liver cells. Hromas, R., Radich, J., Collins, S. Biochem. Biophys. Res. Commun. (1993) [Pubmed]
  9. Homeobox protein Hex facilitates serum responsive factor-mediated activation of the SM22alpha gene transcription in embryonic fibroblasts. Oyama, Y., Kawai-Kowase, K., Sekiguchi, K., Sato, M., Sato, H., Yamazaki, M., Ohyama, Y., Aihara, Y., Iso, T., Okamaoto, E., Nagai, R., Kurabayashi, M. Arterioscler. Thromb. Vasc. Biol. (2004) [Pubmed]
  10. Determination of genotoxic phenylhydrazine agaritine in mushrooms using liquid chromatography-electrospray ionization tandem mass spectrometry. Kondo, K., Watanabe, A., Iwanaga, Y., Abe, I., Tanaka, H., Nagaoka, M.H., Akiyama, H., Maitani, T. Food additives and contaminants. (2006) [Pubmed]
  11. Oligomerisation of the Developmental Regulator Proline Rich Homeodomain (PRH/Hex) is Mediated by a Novel Proline-rich Dimerisation Domain. Soufi, A., Smith, C., Clarke, A.R., Gaston, K., Jayaraman, P.S. J. Mol. Biol. (2006) [Pubmed]
  12. Small bowel causes of per rectum haemorrhage. Klinvimol, T., Ho, Y.H., Parry, B.R., Goh, H.S. Ann. Acad. Med. Singap. (1994) [Pubmed]
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