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Gene Review

snai1a  -  snail family zinc finger 1a

Danio rerio

Synonyms: SO:0000704, cb643, sna-1, sna1, snai1, ...
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High impact information on snai1a


Biological context of snai1a

  • Transcripts of a newly discovered gene called snail2, encoding a zinc finger protein of the Snail family, first appear in rows of cephalic mesendodermal cells in gastrulating zebrafish embryos [5].

Anatomical context of snai1a

  • In situ hybridization shows that the quantity of snail1 RNA increases at the margin of the blastoderm in cells that involute during gastrulation [6].
  • In addition, earlier during development, in the zebrafish gastrula, nrz knockdown results in an increase of snail-1 expression at the margin and frequent gastrulation arrest at the shield stage, independently of apoptosis [1].
  • As gastrulation begins, snail1 RNA disappears from the dorsal axial mesoderm and becomes restricted to the paraxial mesoderm and the tail bud. snail1 RNA increases in cells that define the posterior border of each somite and then disappears when somitic cells differentiate [6].


  1. The zebrafish bcl-2 homologue Nrz controls development during somitogenesis and gastrulation via apoptosis-dependent and -independent mechanisms. Arnaud, E., Ferri, K.F., Thibaut, J., Haftek-Terreau, Z., Aouacheria, A., Le Guellec, D., Lorca, T., Gillet, G. Cell Death Differ. (2006) [Pubmed]
  2. Prep1.1 has essential genetic functions in hindbrain development and cranial neural crest cell differentiation. Deflorian, G., Tiso, N., Ferretti, E., Meyer, D., Blasi, F., Bortolussi, M., Argenton, F. Development (2004) [Pubmed]
  3. Mutations affecting somite formation and patterning in the zebrafish, Danio rerio. van Eeden, F.J., Granato, M., Schach, U., Brand, M., Furutani-Seiki, M., Haffter, P., Hammerschmidt, M., Heisenberg, C.P., Jiang, Y.J., Kane, D.A., Kelsh, R.N., Mullins, M.C., Odenthal, J., Warga, R.M., Allende, M.L., Weinberg, E.S., Nüsslein-Volhard, C. Development (1996) [Pubmed]
  4. The expression of a zebrafish gene homologous to Drosophila snail suggests a conserved function in invertebrate and vertebrate gastrulation. Hammerschmidt, M., Nüsslein-Volhard, C. Development (1993) [Pubmed]
  5. Expression of snail2, a second member of the zebrafish snail family, in cephalic mesendoderm and presumptive neural crest of wild-type and spadetail mutant embryos. Thisse, C., Thisse, B., Postlethwait, J.H. Dev. Biol. (1995) [Pubmed]
  6. Structure of the zebrafish snail1 gene and its expression in wild-type, spadetail and no tail mutant embryos. Thisse, C., Thisse, B., Schilling, T.F., Postlethwait, J.H. Development (1993) [Pubmed]
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