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Gene Review:

cdh4 - cadherin 4, type 1, R-cadherin (retinal)

Danio rerio

Synonyms: R-cadherin, SO:0000704, rcad, zgc:136316

Liu, Q. et al., Liu, Q. et al., Liu, Q. et al., Liu, Q. et al., Liu, Q. et al.

Liu, Londraville, Azodi, Babb, Chiappini-Williamson, Marrs, Raymond, Liu, Frey, Babb-Clendenon, Liu, Francl, Wilson, Marrs, Stenkamp, Liu, Marrs, Raymond, Liu, Babb, Novince, Doedens, Marrs, Raymond, Liu, Marrs, Chuang, Raymond,

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High impact information on cdh4

In this study, we examined expression of zebrafish cadherin-2 (Cdh2, N-cadherin) and cadherin-4 (Cdh4, R-cadherin) in the visual system of adult zebrafish after eye or optic nerve lesions using immunocytochemistry and immunoblotting [1].
Spatial correspondence between R-cadherin expression domains and retinal ganglion cell axons in developing zebrafish [2].
We found that in zebrafish embryos at 46-54 hours postfertilization, DiI-labeled retinal axons were closely associated with cells expressing R-cadherin message in the hypothalamus, the pretectum, and the anterolateral optic tectum [2].
In this study we show that zebrafish cadherin-4 (R-cadherin) transcript (cad4) and protein are expressed in several defined regions in the embryonic forebrain and in distinctive clusters in the hindbrain and spinal cord [3].

Associations of cdh4 with chemical compounds

The present study extends the earlier work by using 1,1'-dioctadecyl-3,3,3',3', tetramethylindocarbocyanine perchlorate (DiI) anterograde tracing techniques to label retinal ganglion cell axons combined with R-cadherin in situ hybridization to explicitly examine the association ofretinal axons and brain regions expressing R-cadherin message [2].

Other interactions of cdh4

Cadherin2 (also called N-cadherin) and cadherin4 (also called R-cadherin), members of the classic cadherin subfamily, have been shown to be involved in development of a variety of tissues and organs including the visual system [4].

Analytical, diagnostic and therapeutic context of cdh4

In this study, we examined distribution of cadherin-2 (Cdh2, N-cadherin) in the visual system of developing and adult zebrafish using both immunocytochemical and in situ hybridization methods, and we compared Cdh2 distribution to that of the previously reported and closely related cadherin-4 (Cdh4, R-cadherin) [5].

References

Up-regulation of cadherin-2 and cadherin-4 in regenerating visual structures of adult zebrafish. Liu, Q., Londraville, R.L., Azodi, E., Babb, S.G., Chiappini-Williamson, C., Marrs, J.A., Raymond, P.A. Exp. Neurol. (2002) [Pubmed]
Spatial correspondence between R-cadherin expression domains and retinal ganglion cell axons in developing zebrafish. Liu, Q., Marrs, J.A., Raymond, P.A. J. Comp. Neurol. (1999) [Pubmed]
Cadherin-4 expression in the zebrafish central nervous system and regulation by ventral midline signaling. Liu, Q., Marrs, J.A., Chuang, J.C., Raymond, P.A. Brain Res. Dev. Brain Res. (2001) [Pubmed]
Differential expression of photoreceptor-specific genes in the retina of a zebrafish cadherin2 mutant glass onion and zebrafish cadherin4 morphants. Liu, Q., Frey, R.A., Babb-Clendenon, S.G., Liu, B., Francl, J., Wilson, A.L., Marrs, J.A., Stenkamp, D.L. Exp. Eye Res. (2007) [Pubmed]
Differential expression of cadherin-2 and cadherin-4 in the developing and adult zebrafish visual system. Liu, Q., Babb, S.G., Novince, Z.M., Doedens, A.L., Marrs, J., Raymond, P.A. Vis. Neurosci. (2001) [Pubmed]

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