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Gene Review

cdh4  -  cadherin 4, type 1, R-cadherin (retinal)

Danio rerio

Synonyms: R-cadherin, SO:0000704, rcad, zgc:136316
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High impact information on cdh4


Associations of cdh4 with chemical compounds


Other interactions of cdh4

  • Cadherin2 (also called N-cadherin) and cadherin4 (also called R-cadherin), members of the classic cadherin subfamily, have been shown to be involved in development of a variety of tissues and organs including the visual system [4].

Analytical, diagnostic and therapeutic context of cdh4

  • In this study, we examined distribution of cadherin-2 (Cdh2, N-cadherin) in the visual system of developing and adult zebrafish using both immunocytochemical and in situ hybridization methods, and we compared Cdh2 distribution to that of the previously reported and closely related cadherin-4 (Cdh4, R-cadherin) [5].


  1. Up-regulation of cadherin-2 and cadherin-4 in regenerating visual structures of adult zebrafish. Liu, Q., Londraville, R.L., Azodi, E., Babb, S.G., Chiappini-Williamson, C., Marrs, J.A., Raymond, P.A. Exp. Neurol. (2002) [Pubmed]
  2. Spatial correspondence between R-cadherin expression domains and retinal ganglion cell axons in developing zebrafish. Liu, Q., Marrs, J.A., Raymond, P.A. J. Comp. Neurol. (1999) [Pubmed]
  3. Cadherin-4 expression in the zebrafish central nervous system and regulation by ventral midline signaling. Liu, Q., Marrs, J.A., Chuang, J.C., Raymond, P.A. Brain Res. Dev. Brain Res. (2001) [Pubmed]
  4. Differential expression of photoreceptor-specific genes in the retina of a zebrafish cadherin2 mutant glass onion and zebrafish cadherin4 morphants. Liu, Q., Frey, R.A., Babb-Clendenon, S.G., Liu, B., Francl, J., Wilson, A.L., Marrs, J.A., Stenkamp, D.L. Exp. Eye Res. (2007) [Pubmed]
  5. Differential expression of cadherin-2 and cadherin-4 in the developing and adult zebrafish visual system. Liu, Q., Babb, S.G., Novince, Z.M., Doedens, A.L., Marrs, J., Raymond, P.A. Vis. Neurosci. (2001) [Pubmed]
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