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Gene Review:

Cdh4 - cadherin 4

Rattus norvegicus

Synonyms: Cadherin-4, R-CAD, R-cadherin, Retinal cadherin

Dorrell, M.I. et al., Slater, S.C. et al., Monks, D.A. et al., Niitsuma, K. et al.

Niitsuma, Hatoko, Kuwahara, Tanaka, Yurugi, Iioka,

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Disease relevance of Cdh4

CONCLUSIONS: These results suggest that R-cadherin expression and beta-catenin signaling may be associated with increased cyclin D1 expression and VSMC proliferation and may therefore play an important role in vascular disease [1].

High impact information on Cdh4

Adult bone marrow-derived stem cells use R-cadherin to target sites of neovascularization in the developing retina [2].
We have analyzed subpopulations of HSCs for the expression of a variety of cell surface adhesion molecules and found that R-cadherin, a calcium-dependent cell-cell adhesion molecule important for normal retinal endothelial cell guidance, was preferentially expressed by functionally targeting HSCs [2].
Semiquantitative PCR revealed that mRNA levels of N-cadherin, but not E-cadherin or R-cadherin, are elevated in castrated rats treated with testosterone, 17 beta-estradiol, or dihydrotestosterone relative to castrate rats not treated with steroids [3].
Localization and expression of R-cadherin in skeletal muscle following nerve injury [4].
METHODS AND RESULTS: We examined the involvement of R-cadherin and beta-catenin in VSMC proliferation in balloon-injured carotid arteries in vivo and aortic rings in vitro [1].

References

R-cadherin:beta-catenin complex and its association with vascular smooth muscle cell proliferation. Slater, S.C., Koutsouki, E., Jackson, C.L., Bush, R.C., Angelini, G.D., Newby, A.C., George, S.J. Arterioscler. Thromb. Vasc. Biol. (2004) [Pubmed]
Adult bone marrow-derived stem cells use R-cadherin to target sites of neovascularization in the developing retina. Dorrell, M.I., Otani, A., Aguilar, E., Moreno, S.K., Friedlander, M. Blood (2004) [Pubmed]
N-cadherin is regulated by gonadal steroids in adult sexually dimorphic spinal motoneurons. Monks, D.A., Getsios, S., MacCalman, C.D., Watson, N.V. J. Neurobiol. (2001) [Pubmed]
Localization and expression of R-cadherin in skeletal muscle following nerve injury. Niitsuma, K., Hatoko, M., Kuwahara, M., Tanaka, A., Yurugi, S., Iioka, H. European surgical research. Europäische chirurgische Forschung. Recherches chirurgicales européennes. (2005) [Pubmed]

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