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Gene Review

CDH4  -  cadherin 4, type 1, R-cadherin (retinal)

Homo sapiens

Synonyms: CAD4, Cadherin-4, R-CAD, R-cadherin, RCAD, ...
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Disease relevance of CDH4

  • Analysis of human primary tumors revealed that the CDH4 gene is methylated in 78% (38 of 49) of colorectal and 95% (20 of 21) of gastric carcinomas [1].
  • Frequent aberrant methylation of the CDH4 gene promoter in human colorectal and gastric cancer [1].

Psychiatry related information on CDH4


High impact information on CDH4


Biological context of CDH4

  • We also proved that CDH4 methylation can be revealed in the peripheral blood of cancer patients [1].
  • These results are consistent with the zipper model, in which the extracellular domain 1 of Cdh4 has intrinsic strand dimer formation activity in addition to adhesion dimer formation activity, both of which are involved in cell adhesion activity [5].
  • To clarify the structural basis of the cell adhesion activity of cadherins, we examined the effects of point mutations of well-conserved amino acid residues in the extracellular domain 1 of cadherin-4 (Cdh4) on the adhesion properties by alanine scanning mutagenesis [5].
  • Assignment of cadherin-4 (R-cadherin, CDH4) to human chromosome band 20q13.3 [6].

Anatomical context of CDH4

  • In addition, we show that R-cadherin induces cell motility when expressed in epithelial cells and that this increased motility is dependent upon Rho GTPase activity [3].
  • In contrast, R-cadherin is found expressed in RMS, whereas it is normally absent in normal myoblasts [4].
  • Here, we summarize experiments that probe the developmental expression and potential significance of a set of cadherins, including M-, N- and R-cadherin, for patterning of the cerebellar cortex [7].

Other interactions of CDH4


Analytical, diagnostic and therapeutic context of CDH4


  1. Frequent aberrant methylation of the CDH4 gene promoter in human colorectal and gastric cancer. Miotto, E., Sabbioni, S., Veronese, A., Calin, G.A., Gullini, S., Liboni, A., Gramantieri, L., Bolondi, L., Ferrazzi, E., Gafà, R., Lanza, G., Negrini, M. Cancer Res. (2004) [Pubmed]
  2. Rapid cycling affective disorder: a descriptive study from North India. Avasthi, A., Sharma, A., Malhotra, S., Gupta, N., Kulhara, P., Malhotra, S. Journal of affective disorders. (1999) [Pubmed]
  3. R-cadherin influences cell motility via Rho family GTPases. Johnson, E., Theisen, C.S., Johnson, K.R., Wheelock, M.J. J. Biol. Chem. (2004) [Pubmed]
  4. Variation in cadherins and catenins expression is linked to both proliferation and transformation of Rhabdomyosarcoma. Charrasse, S., Comunale, F., Gilbert, E., Delattre, O., Gauthier-Rouvière, C. Oncogene (2004) [Pubmed]
  5. Mutation analysis of cadherin-4 reveals amino acid residues of EC1 important for the structure and function. Kitagawa, M., Natori, M., Murase, S., Hirano, S., Taketani, S., Suzuki, S.T. Biochem. Biophys. Res. Commun. (2000) [Pubmed]
  6. Assignment of cadherin-4 (R-cadherin, CDH4) to human chromosome band 20q13.3. Kools, P., Vanhalst, K., van Roy, F. Cytogenet. Cell Genet. (1999) [Pubmed]
  7. Expression of classical cadherins in the cerebellar anlage: Quantitative and functional aspects. Gliem, M., Weisheit, G., Mertz, K.D., Endl, E., Oberdick, J., Schilling, K. Mol. Cell. Neurosci. (2006) [Pubmed]
  8. Endothelial cadherins and tumor angiogenesis. Cavallaro, U., Liebner, S., Dejana, E. Exp. Cell Res. (2006) [Pubmed]
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