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Gene Review

cyp26a1  -  cytochrome P450, family 26, subfamily A,...

Danio rerio

Synonyms: CYP26, Cytochrome P450 26A1, Cytochrome P450RAI, P450RAI, Retinoic acid 4-hydroxylase, ...
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High impact information on cyp26a1

  • Genetic knockdown or pharmacologic inhibition of cyp26a1 in apc(mcr) mutant zebrafish embryos rescued gut differentiation defects such as expression of intestinal fatty acid-binding protein and pancreatic trypsin [1].
  • When the posterior neural gene hoxb1b is expressed during gastrulation, it shows a strikingly complementary pattern to cyp26 [2].
  • Using these two genes, as well as otx2 and meis3 as anterior and posterior markers, we show that Fgf and Wnt signals suppress expression of anterior genes, including cyp26 [2].
  • Cyp26 is first expressed in the presumptive anterior neural ectoderm and the blastoderm margin at the late blastula [2].
  • In COS-1 cells transfected with the P450RAI cDNA, all-trans-RA is rapidly metabolized to more polar metabolites [3].

Biological context of cyp26a1

  • P450RAI represents the first enzymatic component of RA metabolism to be isolated and characterized at the molecular level and provides key insight into regulation of retinoid homeostasis [3].

Anatomical context of cyp26a1

  • The cyp26a1 expression in the rostral spinal cord was strongly upregulated in the gir mutant, suggesting a strong feedback control of its expression by RA signaling [4].
  • We describe the isolation and characterization of a cDNA, P450RAI, encoding a novel member of the cytochrome P450 family. mRNA transcripts for P450RAI are expressed normally during gastrulation, and in a defined pattern in epithelial cells of the regenerating caudal fin in response to exogenous RA [3].
  • Previously, we identified a novel cyp26 gene (cyp26d1) in zebrafish that is expressed in hindbrain during early development [5].

Associations of cyp26a1 with chemical compounds


Other interactions of cyp26a1

  • Strikingly, expression of the RA-degrading enzyme cyp26a1 in the tailbud was controlled by Su(H) activity, and morpholino knockdown of cyp26a1 alone caused asymmetric cyclic dlc expression, suggesting that excess RA in the tailbud may contribute to the cyclic asymmetries [6].
  • These alterations were similar to those caused by the overexpression of cyp26a1 in zebrafish embryos and to that which resulted from treating embryos with 1 microm 4-diethylamino-benzaldehyde (retinal dehydrogenase inhibitor), implying that cyp26d1 can antagonize RA activity in vivo [5].


  1. Up-regulation of CYP26A1 in adenomatous polyposis coli-deficient vertebrates via a WNT-dependent mechanism: implications for intestinal cell differentiation and colon tumor development. Shelton, D.N., Sandoval, I.T., Eisinger, A., Chidester, S., Ratnayake, A., Ireland, C.M., Jones, D.A. Cancer Res. (2006) [Pubmed]
  2. Distinct roles for Fgf, Wnt and retinoic acid in posteriorizing the neural ectoderm. Kudoh, T., Wilson, S.W., Dawid, I.B. Development (2002) [Pubmed]
  3. Identification of the retinoic acid-inducible all-trans-retinoic acid 4-hydroxylase. White, J.A., Guo, Y.D., Baetz, K., Beckett-Jones, B., Bonasoro, J., Hsu, K.E., Dilworth, F.J., Jones, G., Petkovich, M. J. Biol. Chem. (1996) [Pubmed]
  4. Retinoic acid-metabolizing enzyme Cyp26a1 is essential for determining territories of hindbrain and spinal cord in zebrafish. Emoto, Y., Wada, H., Okamoto, H., Kudo, A., Imai, Y. Dev. Biol. (2005) [Pubmed]
  5. A novel cytochrome P450, zebrafish Cyp26D1, is involved in metabolism of all-trans retinoic acid. Gu, X., Xu, F., Song, W., Wang, X., Hu, P., Yang, Y., Gao, X., Zhao, Q. Mol. Endocrinol. (2006) [Pubmed]
  6. Coordination of symmetric cyclic gene expression during somitogenesis by Suppressor of Hairless involves regulation of retinoic acid catabolism. Echeverri, K., Oates, A.C. Dev. Biol. (2007) [Pubmed]
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