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hbae1  -  hemoglobin, alpha embryonic 1

Danio rerio

Synonyms: HBA2r, HBAA1, SI:dZ118J2.10, SI:dZ118J2.8, SO:0000704, ...
 
 
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Disease relevance of hbae1

  • Globin X mRNA significantly decreased under hypoxia, pointing to a functional linkage to oxygen-dependent metabolism [1].
 

High impact information on hbae1

  • During embryogenesis, sau mutants have delayed erythroid maturation and abnormal globin gene expression [2].
  • In addition, conservation of a whole set of transcription factors involved in globin gene switch suggests the regulatory network for such remodeling mechanism existed before the divergence of the teleost and the ancestor of mammals [3].
  • Cells of the ventral blood island (VBI) and the dorsolateral plate (DLP) in embryos differentiate in situ to erythroid cells that contain larval globin mRNA, suggesting that both the VBI and the DLP contribute to "primitive" erythropoiesis [4].
  • It has been implicated in diverse processes such as globin gene expression, oxidative stress, and platelet lineage differentiation [5].
  • Mammalian p45-NFE2 was characterized for its ability to bind the hypersensitive sites of the globin locus control region [5].
 

Analytical, diagnostic and therapeutic context of hbae1

  • Polymerase chain reaction (PCR) amplification of the intergenic globin gene region also detected a 1.0-kb fragment that was repeated in the in group and a 1.2-kb fragment in the out group [6].

References

  1. Hypoxia induces a complex response of globin expression in zebrafish (Danio rerio). Roesner, A., Hankeln, T., Burmester, T. J. Exp. Biol. (2006) [Pubmed]
  2. Positional cloning of the zebrafish sauternes gene: a model for congenital sideroblastic anaemia. Brownlie, A., Donovan, A., Pratt, S.J., Paw, B.H., Oates, A.C., Brugnara, C., Witkowska, H.E., Sassa, S., Zon, L.I. Nat. Genet. (1998) [Pubmed]
  3. Hematopoietic gene expression profile in zebrafish kidney marrow. Song, H.D., Sun, X.J., Deng, M., Zhang, G.W., Zhou, Y., Wu, X.Y., Sheng, Y., Chen, Y., Ruan, Z., Jiang, C.L., Fan, H.Y., Zon, L.I., Kanki, J.P., Liu, T.X., Look, A.T., Chen, Z. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  4. Contribution of ventral and dorsal mesoderm to primitive and definitive erythropoiesis in the salamander Hynobius retardatus. Yamaguchi, M., Wakahara, M. Dev. Biol. (2001) [Pubmed]
  5. Isolation and characterization of zebrafish NFE2. Pratt, S.J., Drejer, A., Foott, H., Barut, B., Brownlie, A., Postlethwait, J., Kato, Y., Yamamoto, M., Zon, L.I. Physiol. Genomics (2002) [Pubmed]
  6. Genomic and phylogenic comparisons of the alpha-globin and beta-globin intergenic sequences between zebra fish (Danio rerio) and six closely related Cyprinindae species. Vidal, G., Scheffler, B., Michel, A., D'Surney, S.J. DNA Cell Biol. (2004) [Pubmed]
 
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