The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

HBZ  -  hemoglobin, zeta

Homo sapiens

Synonyms: HBAZ, HBZ-T1, HBZ1, HBZ2, Hemoglobin subunit zeta, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of HBZ

  • Clones of human embryonic alpha-like zeta-globin cDNA were isolated, by detection using cross-hybridization to human alpha-globin cDNA probes, from a cDNA library derived from the mRNA of the human erythroleukemia cell line K562 [1].
  • Alpha-thalassemia was diagnosed by Southern hybridization of subject's DNA to alpha-, and zeta-globin gene fragments, and to Lo probe if needed [2].
  • The growth-promoting activity of HBZ RNA likely plays an important role in oncogenesis by HTLV-I [3].
  • HBZ, a new important player in the mystery of adult T-cell leukemia [4].
  • Less is known about the other regulatory proteins encoded in this region of the provirus, including the recently discovered HBZ protein [5].

High impact information on HBZ


Chemical compound and disease context of HBZ

  • Here we show that a gene encoded by the minus strand of the HTLV-I proviral genome, HTLV-I basic leucine zipper factor (HBZ), is transcribed from 3'-LTR in all ATL cells [3].

Biological context of HBZ


Anatomical context of HBZ


Associations of HBZ with chemical compounds

  • We showed that the exchange of human zeta-globin for human alpha-globin chains increased haemoglobin O2 affinity, both in the presence and in the absence of 2, 3-bisphosphoglycerate (2,3-BPG), and reduced the pH-dependent shift in its oxygen equilibrium curve (Bohr effect) [16].
  • We show that TF Target Mapper efficiently extracted information on genes around ChIPed sequences, thus identifying known (e.g. alpha-globin and zeta-globin) and potentially novel GATA-1 gene targets [17].
  • However, we demonstrate that the HBZ/CREB-2 heterodimers are no more able to bind to the TxRE and cyclic AMP response element sites [18].
  • A factor binding GATAAG confers tissue specificity on the promoter of the human zeta-globin gene [19].
  • This change may confer a higher intrinsic O2 affinity on the zeta globin protein, ensuring a sufficient O2 supply for the developing goat embryo [20].

Other interactions of HBZ

  • Expression of embryonic zeta-globin and epsilon-globin chains in a 10-year-old girl with congenital anemia [13].
  • Our results support the hypothesis that HBZ could be a negative modulator of the Tax effect by controlling Tax expression at the transcriptional level and by attenuating activation of AP-1 by Tax [21].
  • We then characterized the interaction between HBZ and the cellular transcription factor CREB [5].
  • HBZ is a nuclear basic leucine zipper protein that down-regulates Tax-dependent viral transcription by inhibiting the binding of cAMP-response element-binding protein-2 to the HTLV-I promoter [21].
  • Cell type-specific protein-DNA interactions in the human zeta-globin upstream promoter region: displacement of Sp1 by the erythroid cell-specific factor NF-E1 [22].

Analytical, diagnostic and therapeutic context of HBZ


  1. Cloning and nucleotide sequence analysis of human embryonic zeta-globin cDNA. Cohen-Solal, M.M., Authier, B., deRiel, J.K., Murnane, M.J., Forget, B.G. DNA (1982) [Pubmed]
  2. Prevalence and molecular studies of thalassemia in five aboriginal groups in Taiwan. Ko, T.M., Tseng, L.H., Cheng, T.A., Hwa, H.L., Chang, Y.K., Chuang, S.M., Lee, T.Y. J. Formos. Med. Assoc. (1994) [Pubmed]
  3. HTLV-I basic leucine zipper factor gene mRNA supports proliferation of adult T cell leukemia cells. Satou, Y., Yasunaga, J., Yoshida, M., Matsuoka, M. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  4. HBZ, a new important player in the mystery of adult T-cell leukemia. Mesnard, J.M., Barbeau, B., Devaux, C. Blood (2006) [Pubmed]
  5. Human T-Cell Leukemia Virus Type 1 (HTLV-1) bZIP Protein Interacts with the Cellular Transcription Factor CREB To Inhibit HTLV-1 Transcription. Lemasson, I., Lewis, M.R., Polakowski, N., Hivin, P., Cavanagh, M.H., Thébault, S., Barbeau, B., Nyborg, J.K., Mesnard, J.M. J. Virol. (2007) [Pubmed]
  6. Embryonic zeta-globin chains in adults: a marker for alpha-thalassemia-1 haplotype due to a greater than 17.5-kb deletion. Chui, D.H., Wong, S.C., Chung, S.W., Patterson, M., Bhargava, S., Poon, M.C. N. Engl. J. Med. (1986) [Pubmed]
  7. The structure of the human zeta-globin gene and a closely linked, nearly identical pseudogene. Proudfoot, N.J., Gil, A., Maniatis, T. Cell (1982) [Pubmed]
  8. Sequence organization and genomic complexity of primate theta 1 globin gene, a novel alpha-globin-like gene. Marks, J., Shaw, J.P., Shen, C.K. Nature (1986) [Pubmed]
  9. Identification of a major positive regulatory element located 5' to the human zeta-globin gene. Sabath, D.E., Koehler, K.M., Yang, W.Q., Patton, K., Stamatoyannopoulos, G. Blood (1995) [Pubmed]
  10. zeta-, epsilon-, and gamma-Globin mRNA in blood samples and CD71(+) cell fractions from fetuses and from pregnant and nonpregnant women, with special attention to identification of fetal erythroblasts. Høgh, A.M., Hviid, T.V., Christensen, B., Sørensen, S., Larsen, R.D., Smidt-Jensen, S., Bang, J., Philip, J. Clin. Chem. (2001) [Pubmed]
  11. Activation of the human beta-globin promoter in K562 cells by DNA sequences 5' to the fetal gamma- or embryonic zeta-globin genes. Lin, H.J., Anagnou, N.P., Rutherford, T.R., Shimada, T., Nienhuis, A.W. J. Clin. Invest. (1987) [Pubmed]
  12. "Maturational" globin switching in primary primitive erythroid cells. Kingsley, P.D., Malik, J., Emerson, R.L., Bushnell, T.P., McGrath, K.E., Bloedorn, L.A., Bulger, M., Palis, J. Blood (2006) [Pubmed]
  13. Expression of embryonic zeta-globin and epsilon-globin chains in a 10-year-old girl with congenital anemia. Tang, W., Cai, S.P., Eng, B., Poon, M.C., Waye, J.S., Illum, N., Chui, D.H. Blood (1993) [Pubmed]
  14. Fetal cell identifiers: results of microscope slide-based immunocytochemical studies as a function of gestational age and abnormality. Zheng, Y.L., Zhen, D.K., Farina, A., Berry, S.M., Wapner, R.J., Williams, J.M., Bianchi, D.W. Am. J. Obstet. Gynecol. (1999) [Pubmed]
  15. Comparison of haemoglobin H inclusion bodies with embryonic zeta globin in screening for alpha thalassaemia. Chan, L.C., So, J.C., Chui, D.H. J. Clin. Pathol. (1995) [Pubmed]
  16. Functional effects of replacing human alpha- and beta-globins with their embryonic globin homologues in defined haemoglobin heterotetramers. He, Z., Lian, L., Asakura, T., Russell, J.E. Br. J. Haematol. (2000) [Pubmed]
  17. TF Target Mapper: a BLAST search tool for the identification of Transcription Factor target genes. Horsman, S., Moorhouse, M.J., de Jager, V.C., van der Spek, P., Grosveld, F., Strouboulis, J., Katsantoni, E.Z. BMC Bioinformatics (2006) [Pubmed]
  18. The complementary strand of the human T-cell leukemia virus type 1 RNA genome encodes a bZIP transcription factor that down-regulates viral transcription. Gaudray, G., Gachon, F., Basbous, J., Biard-Piechaczyk, M., Devaux, C., Mesnard, J.M. J. Virol. (2002) [Pubmed]
  19. A factor binding GATAAG confers tissue specificity on the promoter of the human zeta-globin gene. Watt, P., Lamb, P., Squire, L., Proudfoot, N. Nucleic Acids Res. (1990) [Pubmed]
  20. Nucleotide sequence of the goat embryonic alpha globin gene (zeta) and linkage and evolutionary analysis of the complete alpha globin cluster. Wernke, S.M., Lingrel, J.B. J. Mol. Biol. (1986) [Pubmed]
  21. The HBZ factor of human T-cell leukemia virus type I dimerizes with transcription factors JunB and c-Jun and modulates their transcriptional activity. Basbous, J., Arpin, C., Gaudray, G., Piechaczyk, M., Devaux, C., Mesnard, J.M. J. Biol. Chem. (2003) [Pubmed]
  22. Cell type-specific protein-DNA interactions in the human zeta-globin upstream promoter region: displacement of Sp1 by the erythroid cell-specific factor NF-E1. Yu, C.Y., Chen, J., Lin, L.I., Tam, M., Shen, C.K. Mol. Cell. Biol. (1990) [Pubmed]
  23. Persistence or rapid generation of DNA length polymorphism at the zeta-globin locus of humans. Chapman, B.S., Vincent, K.A., Wilson, A.C. Genetics (1986) [Pubmed]
  24. Human embryonic zeta-globin chains in fetal and newborn blood. Chui, D.H., Mentzer, W.C., Patterson, M., Iarocci, T.A., Embury, S.H., Perrine, S.P., Mibashan, R.S., Higgs, D.R. Blood (1989) [Pubmed]
WikiGenes - Universities