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Gene Review

Hba-x  -  hemoglobin X, alpha-like embryonic chain...

Mus musculus

Synonyms: AI450015, Alpha-like embryonic globin chain x, Hbz, Hbz1, Hemoglobin subunit zeta, ...
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Disease relevance of Hba-x


High impact information on Hba-x


Biological context of Hba-x


Anatomical context of Hba-x


Associations of Hba-x with chemical compounds


Regulatory relationships of Hba-x

  • Interestingly, insertion of the PGK-Neo cassette (used to create the null mutation) into the zeta-globin gene appears to influence the expression of the nearby alpha-globin genes, giving rise to reduced alpha-globin production and to an alpha-thalassemia-like syndrome [14].
  • It is shown that tumor necrosis factor-alpha represses the transcription activity directed by either alpha or zeta globin promoter in a dose-dependent manner [18].

Other interactions of Hba-x


Analytical, diagnostic and therapeutic context of Hba-x


  1. DNA-protein interactions in the proximal zeta-globin promoter: identification of novel CCACCC- and CCAAT-binding proteins. Sabath, D.E., Koehler, K.M., Yang, W.Q., Phan, V., Wilson, J. Blood Cells Mol. Dis. (1998) [Pubmed]
  2. Human embryonic zeta-globin gene expression in mouse-human hybrid erythroid cell lines. Luo, H.Y., Deisseroth, A.B., Chui, D.H. Blood (1995) [Pubmed]
  3. Multiple tumor types appear in a transgenic mouse with the ras oncogene. Cardiff, R.D., Leder, A., Kuo, A., Pattengale, P.K., Leder, P. Am. J. Pathol. (1993) [Pubmed]
  4. A farnesyl transferase inhibitor suppresses TPA-mediated skin tumor development without altering hyperplasia in the ras transgenic Tg.AC mouse. Trempus, C.S., Bishop, W.R., Njoroge, F.G., Doll, R.J., Battalora, M.S., Mahler, J.F., Haseman, J.K., Tennant, R.W. Mol. Carcinog. (2000) [Pubmed]
  5. Induction of transgene expression in Tg.AC(v-Ha-ras) transgenic mice concomitant with DNA hypomethylation. Cannon, R.E., Spalding, J.W., Virgil, K.M., Faircloth, R.S., Humble, M.C., Lacks, G.D., Tennant, R.W. Mol. Carcinog. (1998) [Pubmed]
  6. Antisickling effects of an endogenous human alpha-like globin. He, Z., Russell, J.E. Nat. Med. (2004) [Pubmed]
  7. A 3'-flanking NF-kappaB site mediates developmental silencing of the human zeta-globin gene. Wang, Z., Liebhaber, S.A. EMBO J. (1999) [Pubmed]
  8. Derepression of human embryonic zeta-globin promoter by a locus-control region sequence. Huang, B.L., Fan-Chiang, I.R., Wen, S.C., Koo, H.C., Kao, W.Y., Gavva, N.R., Shen, C.K. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  9. v-Ha-ras transgene abrogates the initiation step in mouse skin tumorigenesis: effects of phorbol esters and retinoic acid. Leder, A., Kuo, A., Cardiff, R.D., Sinn, E., Leder, P. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  10. Localization and characterization of the mouse alpha-globin locus control region. Kielman, M.F., Smits, R., Bernini, L.F. Genomics (1994) [Pubmed]
  11. Cloning and characterization of the mouse alpha globin cluster and a new hypervariable marker. Zhao, Q.Z., Liang, X.L., Mitra, S., Gourdon, G., Alter, B.P. Mamm. Genome (1996) [Pubmed]
  12. Characterization, expression, and evolution of the mouse embryonic zeta-globin gene. Leder, A., Weir, L., Leder, P. Mol. Cell. Biol. (1985) [Pubmed]
  13. Developmental silencing of the embryonic zeta-globin gene: concerted action of the promoter and the 3'-flanking region combined with stage-specific silencing by the transcribed segment. Liebhaber, S.A., Wang, Z., Cash, F.E., Monks, B., Russell, J.E. Mol. Cell. Biol. (1996) [Pubmed]
  14. Mouse zeta- and alpha-globin genes: embryonic survival, alpha-thalassemia, and genetic background effects. Leder, A., Daugherty, C., Whitney, B., Leder, P. Blood (1997) [Pubmed]
  15. Differentiation of human embryonic stem cells into embryoid bodies compromising the three embryonic germ layers. Itskovitz-Eldor, J., Schuldiner, M., Karsenti, D., Eden, A., Yanuka, O., Amit, M., Soreq, H., Benvenisty, N. Mol. Med. (2000) [Pubmed]
  16. Effect of zeta-globin substitution on the O2-transport properties of Hb S in vitro and in vivo. He, Z., Russell, J.E. Biochem. Biophys. Res. Commun. (2004) [Pubmed]
  17. Retinoic acid promotes neural and represses mesodermal gene expression in mouse embryonic stem cells in culture. Bain, G., Ray, W.J., Yao, M., Gottlieb, D.I. Biochem. Biophys. Res. Commun. (1996) [Pubmed]
  18. Erythroid gene suppression by NF-kappa B. Liu, J.J., Hou, S.C., Shen, C.K. J. Biol. Chem. (2003) [Pubmed]
  19. Proximal promoter elements of the human zeta-globin gene confer embryonic-specific expression on a linked reporter gene in transgenic mice. Pondel, M.D., Sharpe, J.A., Clark, S., Pearson, L., Wood, W.G., Proudfoot, N.J. Nucleic Acids Res. (1996) [Pubmed]
  20. Evaluation of the Tg.AC assay: specificity testing with three noncarcinogenic pharmaceuticals that induce selected stress gene promoters in vitro and the inhibitory effects of solvent components. Thompson, K.L., Rosenzweig, B.A., Weaver, J.L., Zhang, J., Lin, K.K., Sistare, F.D. Toxicol. Sci. (2003) [Pubmed]
  21. Molecular cloning and sequence analysis of a cDNA coding for the mouse alpha-like embryonic globin chain x. Farace, M.G., Hill, A., Tripodi, M., Padgett, R.W., Raschella, G., Gambari, R., Fantoni, A., Hutchison, C.A., Edgell, M.H. Gene (1984) [Pubmed]
  22. An evaluation of the hemizygous transgenic Tg.AC mouse for carcinogenicity testing of pharmaceuticals. II. A genotypic marker that predicts tumorigenic responsiveness. Thompson, K.L., Rosenzweig, B.A., Sistare, F.D. Toxicologic pathology. (1998) [Pubmed]
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