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Gene Review

Ces1e  -  carboxylesterase 1E

Rattus norvegicus

Synonyms: Carboxyesterase ES-3, Carboxylesterase 1E, Ces1, ES-HTEL, Egasyn, ...
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Disease relevance of Ces1


Psychiatry related information on Ces1

  • Because synthase/carboxylesterase esterifies free fatty acids with ethanol to produce its esters with potentially toxic effects, it may now be feasible to establish a link between alcohol consumption and end-organ damage [6].

High impact information on Ces1


Chemical compound and disease context of Ces1


Biological context of Ces1


Anatomical context of Ces1


Associations of Ces1 with chemical compounds


Physical interactions of Ces1


Regulatory relationships of Ces1


Other interactions of Ces1


Analytical, diagnostic and therapeutic context of Ces1


  1. Prevention of tolerance to the organophosphorus anticholinesterase paraoxon with carboxylesterase inhibitors. Yang, Z.P., Dettbarn, W.D. Biochem. Pharmacol. (1998) [Pubmed]
  2. Identification of two tamoxifen target proteins by photolabeling with 4-(2-morpholinoethoxy)benzophenone. Mésange, F., Sebbar, M., Capdevielle, J., Guillemot, J.C., Ferrara, P., Bayard, F., Poirot, M., Faye, J.C. Bioconjug. Chem. (2002) [Pubmed]
  3. A subchronic inhalation toxicity study of a Matacil formulation in the albino rat. Breckenridge, C., Lulham, G., Hollomby, B., Bier, C., Losos, G., Ecobichon, D.J. Toxicol. Appl. Pharmacol. (1986) [Pubmed]
  4. Carboxylesterases, a key factor in evaluating potential genotoxicity of Trinem antibiotics. Oliver, J., Naidoo, A., Vandin, L., Pugnaghi, F., Gatehouse, D., Comelli, R. Mutagenesis (2000) [Pubmed]
  5. Partial purification and immunological aspects of carboxylesterase from rat liver microsomes. Ishitani, R., Kin, H., Kuwae, T., Moroi, K., Satoh, T. Jpn. J. Pharmacol. (1979) [Pubmed]
  6. Purification and characterization of human heart fatty acid ethyl ester synthase/carboxylesterase. Bora, P.S., Guruge, B.L., Miller, D.D., Chaitman, B.R., Ruyle, M.S. J. Mol. Cell. Cardiol. (1996) [Pubmed]
  7. Human anti-endoplasmic reticulum antibodies in sera of patients with halothane-induced hepatitis are directed against a trifluoroacetylated carboxylesterase. Satoh, H., Martin, B.M., Schulick, A.H., Christ, D.D., Kenna, J.G., Pohl, L.R. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  8. Isolation and characterization of a microsomal acid retinyl ester hydrolase. Linke, T., Dawson, H., Harrison, E.H. J. Biol. Chem. (2005) [Pubmed]
  9. Purification and characterization of a neutral, bile salt-independent retinyl ester hydrolase from rat liver microsomes. Relationship To rat carboxylesterase ES-2. Sun, G., Alexson, S.E., Harrison, E.H. J. Biol. Chem. (1997) [Pubmed]
  10. Rat serum carboxylesterase. Cloning, expression, regulation, and evidence of secretion from liver. Yan, B., Yang, D., Bullock, P., Parkinson, A. J. Biol. Chem. (1995) [Pubmed]
  11. Effect of carboxylesterase inhibition on carbamate protection against soman toxicity. Maxwell, D.M., Brecht, K.M., Lenz, D.E., O'Neill, B.L. J. Pharmacol. Exp. Ther. (1988) [Pubmed]
  12. Carboxylesterase and A-esterase activities during maturation and aging: relationship to the toxicity of chlorpyrifos and parathion in rats. Karanth, S., Pope, C. Toxicol. Sci. (2000) [Pubmed]
  13. Potentiation of acrylate ester toxicity by prior treatment with the carboxylesterase inhibitor triorthotolyl phosphate (TOTP). Silver, E.H., Murphy, S.D. Toxicol. Appl. Pharmacol. (1981) [Pubmed]
  14. The specificity of carboxylesterase protection against the toxicity of organophosphorus compounds. Maxwell, D.M. Toxicol. Appl. Pharmacol. (1992) [Pubmed]
  15. Rat kidney carboxylesterase. Cloning, sequencing, cellular localization, and relationship to rat liver hydrolase. Yan, B., Yang, D., Brady, M., Parkinson, A. J. Biol. Chem. (1994) [Pubmed]
  16. Nucleotide sequence of cDNA coding for rat liver pI 6.1 esterase (ES-10), a carboxylesterase located in the lumen of the endoplasmic reticulum. Robbi, M., Beaufay, H., Octave, J.N. Biochem. J. (1990) [Pubmed]
  17. Rat testicular carboxylesterase: cloning, cellular localization, and relationship to liver hydrolase A. Yan, B., Yang, D., Brady, M., Parkinson, A. Arch. Biochem. Biophys. (1995) [Pubmed]
  18. Evidence for the involvement of a pulmonary first-pass effect via carboxylesterase in the disposition of a propranolol ester derivative after intravenous administration. Imai, T., Yoshigae, Y., Hosokawa, M., Chiba, K., Otagiri, M. J. Pharmacol. Exp. Ther. (2003) [Pubmed]
  19. Molecular cloning and expression of rat lung carboxylesterase and its potential role in the detoxification of organophosphorus compounds. Wallace, T.J., Ghosh, S., McLean Grogan, W. Am. J. Respir. Cell Mol. Biol. (1999) [Pubmed]
  20. Fatty acid ethyl ester synthase in rat adipose tissue and its relationship to carboxylesterase. Tsujita, T., Okuda, H. J. Biol. Chem. (1992) [Pubmed]
  21. The metabolism of N-acetyl-3,5-dimethyl-p-benzoquinone imine in isolated hepatocytes involves N-deacetylation. Rossi, L., McGirr, L.G., Silva, J., O'Brien, P.J. Mol. Pharmacol. (1988) [Pubmed]
  22. The in vitro degradation of cisatracurium, the R, cis-R'-isomer of atracurium, in human and rat plasma. Welch, R.M., Brown, A., Ravitch, J., Dahl, R. Clin. Pharmacol. Ther. (1995) [Pubmed]
  23. Cyclic somatostatin analogs bind specifically to pI 6.1 carboxylesterase of rat liver cells. Wenzel, U., Jouvenal, K., Tripier, D., Ziegler, K. Biochem. Pharmacol. (1995) [Pubmed]
  24. Immunohistochemical localization of carboxylesterase in the nasal mucosa of rats. Olson, M.J., Martin, J.L., LaRosa, A.C., Brady, A.N., Pohl, L.R. J. Histochem. Cytochem. (1993) [Pubmed]
  25. A microscopic and ultrastructural evaluation of dibasic esters (DBE) toxicity in rat nasal explants. Trela, B.A., Frame, S.R., Bogdanffy, M.S. Exp. Mol. Pathol. (1992) [Pubmed]
  26. Specificity of the sex-influenced esterase (ES-SI) isozyme in rat liver. Nikaido, H., Hirose, T., Nikaido, O., Yamada, J., Hayakawa, J. Biochem. Genet. (1991) [Pubmed]
  27. Biosynthesis of rat liver pI-6.1 esterase, a carboxylesterase of the cisternal space of the endoplasmic reticulum. Robbi, M., Beaufay, H. Biochem. J. (1987) [Pubmed]
  28. Acute tabun toxicity; biochemical and histochemical consequences in brain and skeletal muscles of rat. Gupta, R.C., Patterson, G.T., Dettbarn, W.D. Toxicology (1987) [Pubmed]
  29. Purification, characterization and modulation of a microsomal carboxylesterase in rat liver for the hydrolysis of acyl-CoA. Mukherjee, J.J., Jay, F.T., Choy, P.C. Biochem. J. (1993) [Pubmed]
  30. Biotransformation enzymes in the rodent nasal mucosa: the value of a histochemical approach. Bogdanffy, M.S. Environ. Health Perspect. (1990) [Pubmed]
  31. Gene expression changes in rat liver following exposure to liver growth agents: role of Kupffer cells in xenobiotic-mediated liver growth. Crunkhorn, S.E., Plant, K.E., Gibson, G.G., Kramer, K., Lyon, J., Lord, P.G., Plant, N.J. Biochem. Pharmacol. (2004) [Pubmed]
  32. The carboxylesterase family exhibits C-terminal sequence diversity reflecting the presence or absence of endoplasmic-reticulum-retention sequences. Medda, S., Proia, R.L. Eur. J. Biochem. (1992) [Pubmed]
  33. Multiplicity and regulation of hepatic microsomal carboxylesterases in rats. Hosokawa, M., Maki, T., Satoh, T. Mol. Pharmacol. (1987) [Pubmed]
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