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Gene Review

Skp1a  -  S-phase kinase-associated protein 1A

Mus musculus

Synonyms: 15kDa, 2610043E24Rik, 2610206H23Rik, Cyclin-A/CDK2-associated protein p19, EMC19, ...
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Disease relevance of Skp1a


High impact information on Skp1a

  • Purified centrosomes also contain Skp1, and Cul1 modified by the ubiquitin-like molecule NEDD8, suggesting a role for NEDD8 in targeting [2].
  • Using an in vitro assay for centriole separation in Xenopus extracts, antibodies to Skp1 or Cul1 block separation [2].
  • Using immunofluorescence microscopy, we show that in mammalian cells the Skp1 protein and the cullin Cul1 are localized to interphase and mitotic centrosomes and to the cytoplasm and nucleus [2].
  • In contrast, Skp1 engages the SIP CS domain exclusively through weak interactions that are not coupled to the other domains [3].
  • Through interacting with suppressor of the G2 allele of Skp1 (SGT1) and Hsp90, plant CHORD-containing protein RAR1 (required for Mla resistance 1) plays a critical role in disease resistance mediated by multiple R genes [4].

Biological context of Skp1a


Anatomical context of Skp1a

  • Tceb1l shows a restricted pattern of expression in the early mouse embryo, where it is absent from the neurectoderm; later Tceb1l is expressed in the caudal region of the neural tube, followed by widespread expression in many tissues, including the brain and spinal cord [5].
  • Deconvolution and immunoelectron microscopy suggest that Skp1 forms an extended pericentriolar structure that may function to organize the centrosome [2].
  • Further biochemical and biophysical characterization of two low-molecular-weight, strongly acidic proteins that are present at extremely high levels in the organ of Corti, tentatively named OCP-I and OCP-II, is presented [6].
  • These cell lines were all positive for the neuroepithelial precursor cell marker nestin and for the inner ear cell marker OCP2 [8].

Other interactions of Skp1a

  • SCF ubiquitin ligases, composed of three major subunits, Skp1, Cul1, and one of many F box proteins (Fbps), control the proteolysis of important cellular regulators [9].
  • A coimmunoprecipitation assay has revealed the in vivo interaction between Skp1 and Fwd2 through the F-box domain [10].

Analytical, diagnostic and therapeutic context of Skp1a

  • Cell fractionation experiments confirmed that macroH2A1 resides at a pericentrosomal location in close proximity to the known centrosomal proteins gamma-tubulin and Skp1 [11].


  1. Human sequences homologous to the gene for the cochlear protein Ocp-II do not map to currently known non-syndromic hearing loss loci. Brown, K.A., Leek, J.P., Lench, N.J., Moynihan, L.M., Markham, A.F., Mueller, R.F. Ann. Hum. Genet. (1996) [Pubmed]
  2. Components of an SCF ubiquitin ligase localize to the centrosome and regulate the centrosome duplication cycle. Freed, E., Lacey, K.R., Huie, P., Lyapina, S.A., Deshaies, R.J., Stearns, T., Jackson, P.K. Genes Dev. (1999) [Pubmed]
  3. The modular structure of SIP facilitates its role in stabilizing multiprotein assemblies. Bhattacharya, S., Lee, Y.T., Michowski, W., Jastrzebska, B., Filipek, A., Kuznicki, J., Chazin, W.J. Biochemistry (2005) [Pubmed]
  4. Mammalian CHORD-containing protein 1 is a novel heat shock protein 90-interacting protein. Wu, J., Luo, S., Jiang, H., Li, H. FEBS Lett. (2005) [Pubmed]
  5. A novel cDNA with homology to an RNA polymerase II elongation factor maps to human chromosome 5q31 (TCEB1L) and to mouse chromosome 11 (Tceb1l). Sowden, J., Morrison, K., Schofield, J., Putt, W., Edwards, Y. Genomics (1995) [Pubmed]
  6. Biochemical features of major organ of Corti proteins (OCP-I and OCP-II) including partial amino acid sequence. Thalmann, I., Takahashi, K., Varghese, J., Comegys, T.H., Thalmann, R. Laryngoscope (1990) [Pubmed]
  7. Vaccination of mice against schistosoma bovis with a recombinant fatty acid binding protein from Fasciola hepatica. Abáné, J.L., Oleaga, A., Ramajo, V., Casanueva, P., Arellano, J.L., Hillyer, G.V., Muro, A. Vet. Parasitol. (2000) [Pubmed]
  8. Establishment and characterization of conditionally immortalized organ of corti cell lines. Kalinec, F., Kalinec, G., Boukhvalova, M., Kachar, B. Cell Biol. Int. (1999) [Pubmed]
  9. Control of meiotic and mitotic progression by the F box protein beta-Trcp1 in vivo. Guardavaccaro, D., Kudo, Y., Boulaire, J., Barchi, M., Busino, L., Donzelli, M., Margottin-Goguet, F., Jackson, P.K., Yamasaki, L., Pagano, M. Dev. Cell (2003) [Pubmed]
  10. Structure and expression of the gene encoding mouse F-box protein, Fwd2. Miura, M., Hatakeyama, S., Hattori, K., Nakayama, K. Genomics (1999) [Pubmed]
  11. Dynamic relocalization of histone MacroH2A1 from centrosomes to inactive X chromosomes during X inactivation. Rasmussen, T.P., Mastrangelo, M.A., Eden, A., Pehrson, J.R., Jaenisch, R. J. Cell Biol. (2000) [Pubmed]
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