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Gene Review

igfbp1a  -  insulin-like growth factor binding protein 1a

Danio rerio

Synonyms: IGFBP-1, SO:0000704, cb656, igfbp1
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Disease relevance of igfbp1

  • Mutation of this HAS greatly reduced the responsiveness of the IGFBP-1 promoter to hypoxia and HIF-1 [1].

Psychiatry related information on igfbp1


High impact information on igfbp1

  • When tested in vitro with cultured zebrafish embryonic cells, IGFBP-1 itself had no mitogenic activity, but it inhibited IGF-1- and IGF-2-stimulated cell proliferation [3].
  • The hypothesis that elevated IGFBP-1 mediates hypoxia-induced embryonic growth retardation and developmental delay by binding to and inhibiting the activities of IGFs was tested by loss- and gain-of-function approaches [3].
  • This inhibitory effect was abolished when IGF-1 or IGF-2 was added in molar excess, suggesting that IGFBP-1 inhibits embryonic growth and development by binding to and inhibiting the activities of IGFs [3].
  • In early embryos, hypoxia-stimulated IGFBP-1 mRNA expression in the pharyngeal arches, ventricle, atrium, and brain [2].

Biological context of igfbp1


Analytical, diagnostic and therapeutic context of igfbp1

  • Using in situ RNA hybridization and RT-PCR, we discovered that IGFBP-1 mRNA was present in all early embryonic stages albeit at very low levels [2].
  • Sequence analysis indicated that its structure is homologous to mammalian IGFBP-1 [2].


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