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Gene Review

Igfbp1  -  insulin-like growth factor binding protein 1

Rattus norvegicus

Synonyms: IBP-1, IBP1, IGF-BP25, IGF-binding protein 1, IGFBA, ...
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Disease relevance of Igfbp1


Psychiatry related information on Igfbp1

  • Food deprivation for a period of 24 h resulted in a 9.5 +/- 2.0-fold increase in hepatic IGFBP-1 mRNA abundance (P less than 0.001) [5].
  • Thus, the drastic changes in the quantities of IGF, IGFR, and IGFBP mRNAs in the rat masseter muscle between 14 and 19 days of age seem to be involved in the shift of rat feeding behavior [6].

High impact information on Igfbp1

  • In rats with CRF induced by partial renal ablation, 7 days of GH treatment had a diminished effect on weight gain and hepatic IGF-1 and IGFBP-1 mRNA levels, compared with sham-operated pair-fed controls [7].
  • Taken together, these findings are in keeping with the notion and that the apparently enhanced potency of des(1-3)IGF-I (under IGFBP-replete conditions) is due to its diminished affinity for endogenously generated IGFBPs and that rat granulosa cell-derived IGFBPs are inhibitory to IGF (and thus inevitably to gonadotropin) hormonal action [8].
  • Accordingly, the reported ability of gonadotropins to attenuate IGFBP release by granulosa cells may be designed to enhance the bioavailability of endogenously generated IGFs in the best interest of ovarian steroidogenesis [8].
  • In human fibroblast conditioned medium, the Mr = 41,500 and 37,000 IGF binding protein species were abundant, as in normal human plasma, with a major Mr = 23,000 form which was a minor component in plasma [9].
  • Hypoxia stimulates insulin-like growth factor binding protein 1 (IGFBP-1) gene expression in HepG2 cells: a possible model for IGFBP-1 expression in fetal hypoxia [10].

Chemical compound and disease context of Igfbp1


Biological context of Igfbp1


Anatomical context of Igfbp1


Associations of Igfbp1 with chemical compounds


Physical interactions of Igfbp1


Co-localisations of Igfbp1


Regulatory relationships of Igfbp1


Other interactions of Igfbp1


Analytical, diagnostic and therapeutic context of Igfbp1

  • Adrenalectomy had no affect on tibial growth or plasma IGFBP-1 in these animals [22].
  • We here focus on IGFBP expression in the extraembryonic environment, which both supports and constrains embryonic growth, and have used in situ hybridization to determine sites of IGFBP mRNA synthesis in the pregnant rat uterus and placenta [16].
  • Western blotting showed that two IGFBPs of 29-30 and 32 kDa were recognized by antiserum against hIGFBP-1, whereas hepatocytes contained a 1.6 kb transcript on Northern blot with a rat IGFBP-1 cDNA [17].
  • Serum [125I]IGF-I-binding activity was increased 4-fold (P < 0.01), and Western ligand and immunoblotting demonstrated that levels of IGFBP-1 were high in intact STZ-diabetic animals [29].
  • Affinity labeling and immunoprecipitation confirmed that this BP is related to human IGFBP-1 and is distinct from the fetal rat IGFBP, rIGFBP-2 [30].


  1. Dexamethasone stimulates transcription of the insulin-like growth factor-binding protein-1 gene in H4-II-E rat hepatoma cells. Orlowski, C.C., Ooi, G.T., Rechler, M.M. Mol. Endocrinol. (1990) [Pubmed]
  2. Decreased hepatic insulin-like growth factor (IGF)-I and increased IGF binding protein-1 and -2 gene expression in experimental uremia. Tönshoff, B., Powell, D.R., Zhao, D., Durham, S.K., Coleman, M.E., Domené, H.M., Blum, W.F., Baxter, R.C., Moore, L.C., Kaskel, F.J. Endocrinology (1997) [Pubmed]
  3. Mechanisms of thyroid hormone action on the insulin-like growth factor system: all thyroid hormone effects are not growth hormone mediated. Näntö-Salonen, K., Muller, H.L., Hoffman, A.R., Vu, T.H., Rosenfeld, R.G. Endocrinology (1993) [Pubmed]
  4. Physiological concentration of amino acids regulates insulin-like-growth-factor-binding protein 1 expression. Jousse, C., Bruhat, A., Ferrara, M., Fafournoux, P. Biochem. J. (1998) [Pubmed]
  5. Enhanced expression of insulin-like growth factor-binding protein-I in the fasted rat: the effects of insulin and growth hormone administration. Murphy, L.J., Seneviratne, C., Moreira, P., Reid, R.E. Endocrinology (1991) [Pubmed]
  6. Changes in the mRNA expressions of insulin-like growth factors, their receptors, and binding proteins during the postnatal development of rat masseter muscle. Saito, T., Akutsu, S., Urushiyama, T., Ishibashi, K., Nakagawa, Y., Shuler, C.F., Yamane, A. Zool. Sci. (2003) [Pubmed]
  7. Impaired JAK-STAT signal transduction contributes to growth hormone resistance in chronic uremia. Schaefer, F., Chen, Y., Tsao, T., Nouri, P., Rabkin, R. J. Clin. Invest. (2001) [Pubmed]
  8. Granulosa cell-derived insulin-like growth factor (IGF) binding proteins are inhibitory to IGF-I hormonal action. Evidence derived from the use of a truncated IGF-I analogue. Adashi, E.Y., Resnick, C.E., Ricciarelli, E., Hurwitz, A., Kokia, E., Tedeschi, C., Botero, L., Hernandez, E.R., Rosenfeld, R.G., Carlsson-Skwirut, C. J. Clin. Invest. (1992) [Pubmed]
  9. Insulin-like growth factor binding proteins from cultured human fibroblasts. Characterization and hormonal regulation. Conover, C.A., Liu, F., Powell, D., Rosenfeld, R.G., Hintz, R.L. J. Clin. Invest. (1989) [Pubmed]
  10. Hypoxia stimulates insulin-like growth factor binding protein 1 (IGFBP-1) gene expression in HepG2 cells: a possible model for IGFBP-1 expression in fetal hypoxia. Tazuke, S.I., Mazure, N.M., Sugawara, J., Carland, G., Faessen, G.H., Suen, L.F., Irwin, J.C., Powell, D.R., Giaccia, A.J., Giudice, L.C. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  11. Hepatocyte nuclear factor 1 and the glucocorticoid receptor synergistically activate transcription of the rat insulin-like growth factor binding protein-1 gene. Suh, D.S., Rechler, M.M. Mol. Endocrinol. (1997) [Pubmed]
  12. Tubular hypertrophy due to work load induced by furosemide is associated with increases of IGF-1 and IGFBP-1. Kobayashi, S., Clemmons, D.R., Nogami, H., Roy, A.K., Venkatachalam, M.A. Kidney Int. (1995) [Pubmed]
  13. Expression of insulin-like growth factor-I and insulin-like growth factor binding proteins during thioacetamide-induced liver cirrhosis in rats. Novosyadlyy, R., Dargel, R., Scharf, J.G. Growth Horm. IGF Res. (2005) [Pubmed]
  14. Preferential expression of insulin-like growth factor binding proteins-1, -3, and -5 during early diabetic renal hypertrophy in rats. Park, I.S., Kiyomoto, H., Alvarez, F., Xu, Y.C., Abboud, H.E., Abboud, S.L. Am. J. Kidney Dis. (1998) [Pubmed]
  15. Insulin-like Growth Factors and Their Binding Proteins Define Specific Phases of Myometrial Differentiation During Pregnancy in the Rat. Shynlova, O., Tsui, P., Dorogin, A., Langille, B.L., Lye, S.J. Biol. Reprod. (2007) [Pubmed]
  16. Insulin-like growth factor binding protein gene expression in the pregnant rat uterus and placenta. Cerro, J.A., Pintar, J.E. Dev. Biol. (1997) [Pubmed]
  17. Interactive effects of nutrients and hormones on the expression of insulin-like growth factor binding protein-1 (IGFBP-1) mRNA and peptide, and IGF I release from isolated adult rat hepatocytes. Arany, E., Strain, A.J., Hube, M.J., Phillips, I.D., Hill, D.J. J. Cell. Physiol. (1993) [Pubmed]
  18. Complex pattern of insulin-like growth factor binding protein expression in primary rat osteoblast enriched cultures: regulation by prostaglandin E2, growth hormone, and the insulin-like growth factors. McCarthy, T.L., Casinghino, S., Centrella, M., Canalis, E. J. Cell. Physiol. (1994) [Pubmed]
  19. Changes in insulin-like growth factor-binding protein expression and secretion during the proliferation, differentiation, and mineralization of primary cultures of rat osteoblasts. Birnbaum, R.S., Wiren, K.M. Endocrinology (1994) [Pubmed]
  20. Insulin-like growth factor (IGF)-binding protein-1 is highly induced during acute carbon tetrachloride liver injury and potentiates the IGF-I-stimulated activation of rat hepatic stellate cells. Scharf, J.G., Dombrowski, F., Novosyadlyy, R., Eisenbach, C., Demori, I., Kübler, B., Braulke, T. Endocrinology (2004) [Pubmed]
  21. Octreotide prevents the early increase in renal insulin-like growth factor binding protein 1 in streptozotocin diabetic rats. Raz, I., Rubinger, D., Popovtzer, M., Grønbaek, H., Weiss, O., Flyvbjerg, A. Diabetes (1998) [Pubmed]
  22. Corticosterone regulation of insulin-like growth factor I, IGF-binding proteins, and growth in streptozotocin-induced diabetic rats. Rodgers, B.D., Strack, A.M., Dallman, M.F., Hwa, L., Nicoll, C.S. Diabetes (1995) [Pubmed]
  23. Growth promotion by insulin-like growth factor I in hypophysectomized and diabetic rats. Zapf, J. Mol. Cell. Endocrinol. (1998) [Pubmed]
  24. Platelet-derived growth factor isoforms decrease insulin-like growth factor I gene expression in rat vascular smooth muscle cells and selectively stimulate the biosynthesis of insulin-like growth factor binding protein 4. Giannella-Neto, D., Kamyar, A., Sharifi, B., Pirola, C.J., Kupfer, J., Rosenfeld, R.G., Forrester, J.S., Fagin, J.A. Circ. Res. (1992) [Pubmed]
  25. The role for the uterine insulin-like growth factor I in early embryonic loss after superovulation in the rat. Katagiri, S., Moon, Y.S., Yuen, B.H. Fertil. Steril. (1996) [Pubmed]
  26. Insulin-like growth factor (IGF) binding proteins modulate the glucocorticoid-dependent biological effects of IGF-II in cultured fetal rat hepatocytes. Menuelle, P., Babajko, S., Plas, C. Endocrinology (1999) [Pubmed]
  27. Regulation of insulin-like growth factor-I and of insulin-like growth factor binding protein-1, -3 and -4 in cocultures of rat hepatocytes and Kupffer cells by interleukin-6. Lelbach, A., Scharf, J.G., Ramadori, G. J. Hepatol. (2001) [Pubmed]
  28. Effect of transforming growth factor-beta on the insulin-like growth factor-I autocrine/paracrine axis in cultured rat articular chondrocytes. Tsukazaki, T., Usa, T., Matsumoto, T., Enomoto, H., Ohtsuru, A., Namba, H., Iwasaki, K., Yamashita, S. Exp. Cell Res. (1994) [Pubmed]
  29. Effects of glucocorticoids on circulating levels and hepatic expression of insulin-like growth factor (IGF)-binding proteins and IGF-I in the adrenalectomized streptozotocin-diabetic rat. Unterman, T.G., Jentel, J.J., Oehler, D.T., Lacson, R.G., Hofert, J.F. Endocrinology (1993) [Pubmed]
  30. Production of the rat type 1 insulin-like growth factor-binding protein by well differentiated H4EIIC3 hepatoma cells: identification, purification, and N-terminal amino acid analysis. Unterman, T.G., Oehler, D.T., Gotway, M.B., Morris, P.W. Endocrinology (1990) [Pubmed]
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