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Gene Review

igf1  -  insulin-like growth factor 1

Danio rerio

Synonyms: IGF-1, IGF-1L, IGF-1a, IGF-I, SO:0000704
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Disease relevance of igf1

  • Hypoxia strongly induced the expression of insulin-like growth factor (IGF)-binding protein (IGFBP)-1, a secreted protein that binds IGFs in extracellular environments [1].
  • Targeted knock-down of IGFBP-2 by antisense morpholino-modified oligonucleotides resulted in delayed development, reduced body growth, reduced IGF-I mRNA levels, and disruptions to cardiovascular development, including reduced blood cell number, reduced blood circulation, cardiac dysfunction, and brain ventricle edema [2].

High impact information on igf1

  • When tested in vitro with cultured zebrafish embryonic cells, IGFBP-1 itself had no mitogenic activity, but it inhibited IGF-1- and IGF-2-stimulated cell proliferation [1].
  • This inhibitory effect was abolished when IGF-1 or IGF-2 was added in molar excess, suggesting that IGFBP-1 inhibits embryonic growth and development by binding to and inhibiting the activities of IGFs [1].
  • Furthermore, the emergence of the zebrafish as a preferred model for development genetics has spawned progress in determining the requirements for IGF signaling during vertebrate embryonic development [3].
  • Sequence comparison showed that the primary structures of zebrafish IGF-I, IGF-II, and IGF-I receptors (IGF-IRs) have been highly conserved in vertebrates [4].
  • Moreover, analyses of MRFs, MSP, and IGFs in the knock-down embryos by RT-PCR revealed the up-regulation of MyoD, Myogenin, and Mck transcription, whereas IGF-2 transcription showed mild response with no effect on IGF-1, Desmin, and Myf5 [5].

Biological context of igf1


Anatomical context of igf1


Associations of igf1 with chemical compounds

  • Similarly, use of the PI3 kinase inhibitor LY-294002 also inhibited IGF-I-stimulated DNA synthesis [9].
  • To study the interplay between GH, IGF-I, and their receptors, postsmolt Atlantic salmon were studied during spring growth (January-June 2003) [6].
  • Based on two cDNAs sequence with different length of 5'- and 3'-untranslated region (5UTR and 3UTR) and one nucleotide difference at glutamine (A9, CAG) of A domain represented at IGF-1 sequence [7].

Analytical, diagnostic and therapeutic context of igf1


  1. Insulin-like growth factor-binding protein-1 (IGFBP-1) mediates hypoxia-induced embryonic growth and developmental retardation. Kajimura, S., Aida, K., Duan, C. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  2. Targeted knockdown of insulin-like growth factor binding protein-2 disrupts cardiovascular development in zebrafish embryos. Wood, A.W., Schlueter, P.J., Duan, C. Mol. Endocrinol. (2005) [Pubmed]
  3. Insulin-like growth factor signaling in fish. Wood, A.W., Duan, C., Bern, H.A. Int. Rev. Cytol. (2005) [Pubmed]
  4. Structural, biochemical, and expression analysis of two distinct insulin-like growth factor I receptors and their ligands in zebrafish. Maures, T., Chan, S.J., Xu, B., Sun, H., Ding, J., Duan, C. Endocrinology (2002) [Pubmed]
  5. Up-regulation of muscle-specific transcription factors during embryonic somitogenesis of zebrafish (Danio rerio) by knock-down of myostatin-1. Amali, A.A., Lin, C.J., Chen, Y.H., Wang, W.L., Gong, H.Y., Lee, C.Y., Ko, Y.L., Lu, J.K., Her, G.M., Chen, T.T., Wu, J.L. Dev. Dyn. (2004) [Pubmed]
  6. A peak in gh-receptor expression is associated with growth activation in Atlantic salmon vertebrae, while upregulation of igf-I receptor expression is related to increased bone density. Wargelius, A., Fjelldal, P.G., Benedet, S., Hansen, T., Björnsson, B.T., Nordgarden, U. Gen. Comp. Endocrinol. (2005) [Pubmed]
  7. The characterization of prepro-insulin-like growth factor-1 Ea-2 expression and insulin-like growth factor-1 genes (devoid 81 bp) in the zebrafish (Danio rerio). Chen, M.H., Lin, G., Gong, H., Weng, C., Chang, C., Wu, J. Gene (2001) [Pubmed]
  8. The physiological role of CTGF/CCN2 in zebrafish notochond development and biological analysis of the proximal promoter region. Chiou, M.J., Chao, T.T., Wu, J.L., Kuo, C.M., Chen, J.Y. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
  9. IGFs stimulate zebrafish cell proliferation by activating MAP kinase and PI3-kinase-signaling pathways. Pozios, K.C., Ding, J., Degger, B., Upton, Z., Duan, C. Am. J. Physiol. Regul. Integr. Comp. Physiol. (2001) [Pubmed]
  10. Isolation and characterization of tilapia (Oreochromis mossambicus) insulin-like growth factors gene and proximal promoter region. Chen, J.Y., Tsai, H.L., Chang, C.Y., Wang, J.I., Shen, S.C., Wu, J.L. DNA Cell Biol. (1998) [Pubmed]
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