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Gene Review

His2B:CG17949  -  CG17949 gene product from transcript...

Drosophila melanogaster

Synonyms: CG17949, Dmel\CG17949
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High impact information on His2B:CG17949

  • A 3-kilobase DNA segment characteristic of a transposable element was found within a histone H2B pseudogene in a higher eukaryote, the sea urchin Stronglyocentrotus purpuratus [1].
  • This heat-shock polypeptide was identified as histone H2b by two criteria: (a) it comigrated with authentic histone H2b in Triton-urea-acetic acid acrylamide gel electrophoresis after solubilization from nuclei with acid; and (b) partial proteolysis peptide maps of the basic heat-shock protein and histone H2b were identical [2].
  • The Drosophila nuclear lamina protein YA binds to DNA and histone H2B with four domains [3].
  • These stress-induced changes in the methylation level of the N-terminal proline residue of histone H2B and shift in the methylation sites of histone H3 may be involved in the restructuration of chromatin accompanying the inactivation of normal genes in response to stress [4].
  • Both types of stress induce a rapid increase in the methylation level of histone H2B [4].

Biological context of His2B:CG17949


Associations of His2B:CG17949 with chemical compounds


Enzymatic interactions of His2B:CG17949

  • Here we report that histone H2B is phosphorylated at evolutionarily conserved Ser33 (H2B-S33) by the carboxyl-terminal kinase domain (CTK) of the Drosophila TFIID subunit TAF1 [6].

Other interactions of His2B:CG17949

  • YA's binding to DNA and histone H2B is mediated by four domains distributed along the length of the YA molecule [3].

Analytical, diagnostic and therapeutic context of His2B:CG17949

  • Semi-quantitative RT-PCR indicated that after heat-shock treatment, the expression levels of histone H3, histone H2B and TCTP increased 4.8, 27 and 5.7-fold, respectively [11].


  1. An unusual transposon with long terminal inverted repeats in the sea urchin Strongylocentrotus purpuratus. Liebermann, D., Hoffman-Liebermann, B., Weinthal, J., Childs, G., Maxson, R., Mauron, A., Cohen, S.N., Kedes, L. Nature (1983) [Pubmed]
  2. Identification of histone H2b as a heat-shock protein in Drosophila. Sanders, M.M. J. Cell Biol. (1981) [Pubmed]
  3. The Drosophila nuclear lamina protein YA binds to DNA and histone H2B with four domains. Yu, J., Wolfner, M.F. Mol. Biol. Cell (2002) [Pubmed]
  4. Methylation of Drosophila histones at proline, lysine, and arginine residues during heat shock. Desrosiers, R., Tanguay, R.M. J. Biol. Chem. (1988) [Pubmed]
  5. The human homologue of the RNA polymerase II-associated factor 1 (hPaf1), localized on the 19q13 amplicon, is associated with tumorigenesis. Moniaux, N., Nemos, C., Schmied, B.M., Chauhan, S.C., Deb, S., Morikane, K., Choudhury, A., Vanlith, M., Sutherlin, M., Sikela, J.M., Hollingsworth, M.A., Batra, S.K. Oncogene (2006) [Pubmed]
  6. TAF1 activates transcription by phosphorylation of serine 33 in histone H2B. Maile, T., Kwoczynski, S., Katzenberger, R.J., Wassarman, D.A., Sauer, F. Science (2004) [Pubmed]
  7. Periodic binding of individual core histones to DNA: inadvertent purification of the core histone H2B as a putative enhancer-binding factor. Kerrigan, L.A., Kadonaga, J.T. Nucleic Acids Res. (1992) [Pubmed]
  8. Multiple forms of histone H2B from the nematode Caenorhabditis elegans. Vanfleteren, J.R., Van Bun, S.M., Delcambe, L.L., Van Beeumen, J.J. Biochem. J. (1986) [Pubmed]
  9. Two types of polyadenated mRNAs are synthesized from Drosophila replication-dependent histone genes. Akhmanova, A., Miedema, K., Kremer, H., Hennig, W. Eur. J. Biochem. (1997) [Pubmed]
  10. Drosophila cAMP-dependent protein kinase. Foster, J.L., Guttman, J.J., Hall, L.M., Rosen, O.M. J. Biol. Chem. (1984) [Pubmed]
  11. Identification of some heat-induced genes of Trichinella spiralis. Mak, C.H., Su, K.W., Ko, R.C. Parasitology (2001) [Pubmed]
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