Gene Review:
Nck1 - non-catalytic region of tyrosine kinase...
Mus musculus
Synonyms:
6330586M15Rik, Cytoplasmic protein NCK1, D230010O13Rik, NCK adaptor protein 1, Nck, ...
- Nck adaptor proteins link nephrin to the actin cytoskeleton of kidney podocytes. Jones, N., Blasutig, I.M., Eremina, V., Ruston, J.M., Bladt, F., Li, H., Huang, H., Larose, L., Li, S.S., Takano, T., Quaggin, S.E., Pawson, T. Nature (2006)
- Cloning, sequencing, and overexpression of SH2/SH3 adaptor protein Nck from mouse thymus. Park, D. Mol. Cells (1997)
- Two species of mRNAs for the fyn proto-oncogene are produced by an alternative polyadenylation. Lee, C., Kim, M.G., Jeon, S.H., Park, D.E., Park, S.D., Seong, R.H. Mol. Cells (1998)
- Recruitment of Nck by CD3 epsilon reveals a ligand-induced conformational change essential for T cell receptor signaling and synapse formation. Gil, D., Schamel, W.W., Montoya, M., Sánchez-Madrid, F., Alarcón, B. Cell (2002)
- Actin-based motility of vaccinia virus mimics receptor tyrosine kinase signalling. Frischknecht, F., Moreau, V., Röttger, S., Gonfloni, S., Reckmann, I., Superti-Furga, G., Way, M. Nature (1999)
- Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1. Tamemoto, H., Kadowaki, T., Tobe, K., Yagi, T., Sakura, H., Hayakawa, T., Terauchi, Y., Ueki, K., Kaburagi, Y., Satoh, S. Nature (1994)
- Abl protein-tyrosine kinase selects the Crk adapter as a substrate using SH3-binding sites. Ren, R., Ye, Z.S., Baltimore, D. Genes Dev. (1994)
- The murine Nck SH2/SH3 adaptors are important for the development of mesoderm-derived embryonic structures and for regulating the cellular actin network. Bladt, F., Aippersbach, E., Gelkop, S., Strasser, G.A., Nash, P., Tafuri, A., Gertler, F.B., Pawson, T. Mol. Cell. Biol. (2003)
- The adaptor protein Nck1 mediates endothelin A receptor-regulated cell migration through the Cdc42-dependent c-Jun N-terminal kinase pathway. Miyamoto, Y., Yamauchi, J., Mizuno, N., Itoh, H. J. Biol. Chem. (2004)
- Dok-related protein negatively regulates T cell development via its RasGTPase-activating protein and Nck docking sites. Gugasyan, R., Quilici, C., I, S.T., Grail, D., Verhagen, A.M., Roberts, A., Kitamura, T., Dunn, A.R., Lock, P. J. Cell Biol. (2002)
- c-Abl phosphorylates Dok1 to promote filopodia during cell spreading. Woodring, P.J., Meisenhelder, J., Johnson, S.A., Zhou, G.L., Field, J., Shah, K., Bladt, F., Pawson, T., Niki, M., Pandolfi, P.P., Wang, J.Y., Hunter, T. J. Cell Biol. (2004)
- Modulation of protein translation by Nck-1. Kebache, S., Zuo, D., Chevet, E., Larose, L. Proc. Natl. Acad. Sci. U.S.A. (2002)
- Activation of the Abl tyrosine kinase in vivo by Src homology 3 domains from the Src homology 2/Src homology 3 adaptor Nck. Smith, J.M., Katz, S., Mayer, B.J. J. Biol. Chem. (1999)
- The CD3epsilon proline-rich sequence, and its interaction with Nck, is not required for T cell development and function. Szymczak, A.L., Workman, C.J., Gil, D., Dilioglou, S., Vignali, K.M., Palmer, E., Vignali, D.A. J. Immunol. (2005)
- Juxtamembrane tyrosine residues couple the Eph family receptor EphB2/Nuk to specific SH2 domain proteins in neuronal cells. Holland, S.J., Gale, N.W., Gish, G.D., Roth, R.A., Songyang, Z., Cantley, L.C., Henkemeyer, M., Yancopoulos, G.D., Pawson, T. EMBO J. (1997)
- Independent SH2-binding sites mediate interaction of Dok-related protein with RasGTPase-activating protein and Nck. Lock, P., Casagranda, F., Dunn, A.R. J. Biol. Chem. (1999)
- The SH2/SH3 domain-containing protein Nck is recognized by certain anti-phospholipase C-gamma 1 monoclonal antibodies, and its phosphorylation on tyrosine is stimulated by platelet-derived growth factor and epidermal growth factor treatment. Meisenhelder, J., Hunter, T. Mol. Cell. Biol. (1992)
- Requirement of Nck adaptors for actin dynamics and cell migration stimulated by platelet-derived growth factor B. Rivera, G.M., Antoku, S., Gelkop, S., Shin, N.Y., Hanks, S.K., Pawson, T., Mayer, B.J. Proc. Natl. Acad. Sci. U.S.A. (2006)
- Activation of the nonreceptor protein tyrosine kinase Ack by multiple extracellular stimuli. Galisteo, M.L., Yang, Y., Ureña, J., Schlessinger, J. Proc. Natl. Acad. Sci. U.S.A. (2006)
- Src homology region 2 domain-containing phosphatase 1 positively regulates B cell receptor-induced apoptosis by modulating association of B cell linker protein with Nck and activation of c-Jun NH2-terminal kinase. Mizuno, K., Tagawa, Y., Mitomo, K., Watanabe, N., Katagiri, T., Ogimoto, M., Yakura, H. J. Immunol. (2002)
- Nck adaptor proteins link Tks5 to invadopodia actin regulation and ECM degradation. Stylli, S.S., Stacey, T.T., Verhagen, A.M., Xu, S.S., Pass, I., Courtneidge, S.A., Lock, P. J. Cell. Sci. (2009)
- EphB1-mediated cell migration requires the phosphorylation of paxillin at Tyr-31/Tyr-118. Vindis, C., Teli, T., Cerretti, D.P., Turner, C.E., Huynh-Do, U. J. Biol. Chem. (2004)
- Novel p62dok family members, dok-4 and dok-5, are substrates of the c-Ret receptor tyrosine kinase and mediate neuronal differentiation. Grimm, J., Sachs, M., Britsch, S., Di Cesare, S., Schwarz-Romond, T., Alitalo, K., Birchmeier, W. J. Cell Biol. (2001)
- Tyrosine phosphorylation of caveolin-2 at residue 27: differences in the spatial and temporal behavior of phospho-Cav-2 (pY19 and pY27). Wang, X.B., Lee, H., Capozza, F., Marmon, S., Sotgia, F., Brooks, J.W., Campos-Gonzalez, R., Lisanti, M.P. Biochemistry (2004)
- Insulin-like growth factor-I stimulates tyrosine phosphorylation of endogenous c-Crk. Beitner-Johnson, D., LeRoith, D. J. Biol. Chem. (1995)
- Compensatory alterations for insulin signal transduction and glucose transport in insulin-resistant diabetes. Bonini, J.A., Colca, J.R., Dailey, C., White, M., Hofmann, C. Am. J. Physiol. (1995)
- The Nck SH2/SH3 adaptor protein is present in the nucleus and associates with the nuclear protein SAM68. Lawe, D.C., Hahn, C., Wong, A.J. Oncogene (1997)
- R-Ras contains a proline-rich site that binds to SH3 domains and is required for integrin activation by R-Ras. Wang, B., Zou, J.X., Ek-Rylander, B., Ruoslahti, E. J. Biol. Chem. (2000)