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Gene Review

EHI_116360  -  serine-rich protein

Entamoeba histolytica HM-1:IMSS

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Disease relevance of 500.t00001


High impact information on 500.t00001


Chemical compound and disease context of 500.t00001


Biological context of 500.t00001

  • We conclude that there is genetic diversity within E. histolytica isolates from an endemic population as reflected in serine-rich E. histolytica protein gene polymorphism [11].

Analytical, diagnostic and therapeutic context of 500.t00001

  • Sequence analysis revealed that the specific probe represents a copy of the multicopy ariel gene family, which has 80% sequence identity to srehp, the gene encoding a serine-rich E. histolytica membrane protein [12].


  1. Oral immunization with an attenuated vaccine strain of Salmonella typhimurium expressing the serine-rich Entamoeba histolytica protein induces an antiamebic immune response and protects gerbils from amebic liver abscess. Zhang, T., Stanley, S.L. Infect. Immun. (1996) [Pubmed]
  2. Oral immunization with attenuated vaccine strains of Vibrio cholerae expressing a dodecapeptide repeat of the serine-rich Entamoeba histolytica protein fused to the cholera toxin B subunit induces systemic and mucosal antiamebic and anti-V. cholerae antibody responses in mice. Ryan, E.T., Butterton, J.R., Zhang, T., Baker, M.A., Stanley, S.L., Calderwood, S.B. Infect. Immun. (1997) [Pubmed]
  3. DNA vaccination with the serine rich Entamoeba histolytica protein (SREHP) prevents amebic liver abscess in rodent models of disease. Zhang, T., Stanley, S.L. Vaccine (1999) [Pubmed]
  4. Cloning and characterization of Entamoeba histolytica antigens recognized by human secretory IgA antibodies. Carrero, J.C., Petrossian, P., Acosta, E., Sánchez-Zerpa, M., Ortiz-Ortiz, L., Laclette, J.P. Parasitol. Res. (2000) [Pubmed]
  5. The serine-rich Entamoeba histolytica protein is a phosphorylated membrane protein containing O-linked terminal N-acetylglucosamine residues. Stanley, S.L., Tian, K., Koester, J.P., Li, E. J. Biol. Chem. (1995) [Pubmed]
  6. A new gene family (ariel) encodes asparagine-rich Entamoeba histolytica antigens, which resemble the amebic vaccine candidate serine-rich E. histolytica protein. Mai, Z., Samuelson, J. Infect. Immun. (1998) [Pubmed]
  7. Host-parasite relationships in amebiasis: conference report. Petri, W.A., Clark, C.G., Diamond, L.S. J. Infect. Dis. (1994) [Pubmed]
  8. Short report: identification of B-cell epitopes in the serine-rich Entamoeba histolytica protein. Wang, L., Calderon, J., Stanley, S.L. Am. J. Trop. Med. Hyg. (1997) [Pubmed]
  9. Prevalence and genetic diversity of Entamoeba histolytica in an institution for the mentally retarded in the Philippines. Rivera, W.L., Santos, S.R., Kanbara, H. Parasitol. Res. (2006) [Pubmed]
  10. Immunogenicity of the recombinant serine rich Entamoeba histolytica protein (SREHP) amebiasis vaccine in the African green monkey. Stanley, S.L., Blanchard, J.L., Johnson, N., Foster, L., Kunz-Jenkins, C., Zhang, T., Tian, K., Cogswell, F.B. Vaccine (1995) [Pubmed]
  11. Entamoeba histolytica: genetic diversity of clinical isolates from Bangladesh as demonstrated by polymorphisms in the serine-rich gene. Ayeh-Kumi, P.F., Ali, I.M., Lockhart, L.A., Gilchrist, C.A., Petri, W.A., Haque, R. Exp. Parasitol. (2001) [Pubmed]
  12. DNA sequences corresponding to the ariel gene family of Entamoeba histolytica are not present in E. dispar. Willhoeft, U., Buss, H., Tannich, E. Parasitol. Res. (1999) [Pubmed]
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