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Gene Review

Dh31  -  Diuretic hormone 31

Drosophila melanogaster

Synonyms: CG13094, DH 31, DH(31), DH-II, DH31, ...
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Disease relevance of Dh31


High impact information on Dh31

  • CG17415 antibodies revealed expression within the principal cells of Malpighian tubules, further implicating DH31 as a ligand for this receptor [2].
  • Using an antibody raised against D. punctata (Dippu) DH31, we demonstrate the presence of Dippu-DH31-like immunoreactivity in the CNS, salivary glands, hindgut and neurohemal sites of 5th instar Rhodnius [3].
  • The identification of a Drosophila receptor for the DH neuropeptide provides a basis for genetic analysis of this critical factor's roles in maintaining physiological homeostasis [4].
  • When expressed in mammalian cells, CG8422 conferred selective sensitivity to DH, as indicated by translocation of a beta-arrestin-2-GFP reporter from the cytoplasm to the cell membrane [4].
  • The Dh gene of Drosophila melanogaster encodes a diuretic peptide that acts through cyclic AMP [5].

Biological context of Dh31


Anatomical context of Dh31


Associations of Dh31 with chemical compounds


Regulatory relationships of Dh31


Other interactions of Dh31

  • These cells also express receptors for leucokinin, another major diuretic peptide, implying that the cells may be important in homeostatic regulation [5].


  1. Effects of leucokinin-VIII on Aedes Malpighian tubule segments lacking stellate cells. Yu, M.J., Beyenbach, K.W. J. Exp. Biol. (2004) [Pubmed]
  2. A novel diuretic hormone receptor in Drosophila: evidence for conservation of CGRP signaling. Johnson, E.C., Shafer, O.T., Trigg, J.S., Park, J., Schooley, D.A., Dow, J.A., Taghert, P.H. J. Exp. Biol. (2005) [Pubmed]
  3. Presence and activity of a Dippu-DH31-like peptide in the blood-feeding bug, Rhodnius prolixus. Te Brugge, V.A., Lombardi, V.C., Schooley, D.A., Orchard, I. Peptides (2005) [Pubmed]
  4. Drosophila CG8422 encodes a functional diuretic hormone receptor. Johnson, E.C., Bohn, L.M., Taghert, P.H. J. Exp. Biol. (2004) [Pubmed]
  5. The Dh gene of Drosophila melanogaster encodes a diuretic peptide that acts through cyclic AMP. Cabrero, P., Radford, J.C., Broderick, K.E., Costes, L., Veenstra, J.A., Spana, E.P., Davies, S.A., Dow, J.A. J. Exp. Biol. (2002) [Pubmed]
  6. The Drosophila melanogaster homologue of an insect calcitonin-like diuretic peptide stimulates V-ATPase activity in fruit fly Malpighian tubules. Coast, G.M., Webster, S.G., Schegg, K.M., Tobe, S.S., Schooley, D.A. J. Exp. Biol. (2001) [Pubmed]
  7. Cloning and expression analysis of a 5HT7-like serotonin receptor cDNA from mosquito Aedes aegypti female excretory and respiratory systems. Pietrantonio, P.V., Jagge, C., McDowell, C. Insect Mol. Biol. (2001) [Pubmed]
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