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Chemical Compound Review

Cyclic AMP, 8-bromo     8-(6-amino-8-bromo-purin-9- yl)-3-hydroxy-3...

Synonyms: CHEMBL85519, AGN-PC-00IQQN, SureCN5951342, NSC-171719, AC1L1CIC, ...
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Disease relevance of Cyclic AMP, 8-bromo


High impact information on Cyclic AMP, 8-bromo


Chemical compound and disease context of Cyclic AMP, 8-bromo


Biological context of Cyclic AMP, 8-bromo


Anatomical context of Cyclic AMP, 8-bromo

  • We further show that VGF mRNA is induced in PC12 cells to a greater extent by depolarization and by phorbol-12-myristate-13-acetate treatment than by 8-bromo-cyclic AMP treatment [17].
  • Exposure of the normally non-fusing BeWo cells to 1.5 mM 8-bromo cyclic AMP induced cellular fusion and syncytium formation [18].
  • When veratrine-induced release of [3H]norepinephrine from cortex synaptosomes was examined, the facilitatory effects of forskolin, 8-bromo-cyclic AMP, and ZK 62771 were even more pronounced than in brain slices [19].
  • The PKA pathway seemed to inhibit both neoplastic and normal IFN-gamma-induced HLA-DR expression; addition of thyroid-stimulating hormone to normal thyroid cells, as well as 8-bromo cyclic AMP and forskolin to normal and neoplastic cells, reduced the amount of IFN-gamma-induced HLA-DR [20].
  • Regulation of low density lipoprotein receptor synthesis in cultured luteinized human granulosa cells by human chorionic gonadotropin and 8-bromo-cyclic AMP [21].

Associations of Cyclic AMP, 8-bromo with other chemical compounds


Gene context of Cyclic AMP, 8-bromo


Analytical, diagnostic and therapeutic context of Cyclic AMP, 8-bromo


  1. Adenosine 3',5'-monophosphate analogs promote a circular morphology of cultured Schwannoma cells. Sheppard, J.R., Hudson, T.H., Larson, J.R. Science (1975) [Pubmed]
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  3. Biphasic regulation of the messenger ribonucleic acid coding for the estrogen receptor by cyclic adenosine 3':5'-monophosphate in tumor Leydig cells. Ree, A.H., Frøysa, A., Eskild, W., Jahnsen, T., Hansson, V. Cancer Res. (1990) [Pubmed]
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  5. Expression and regulation of retinoid X receptors in B16 melanoma cells. Desai, D.S., Niles, R.M. J. Cell. Physiol. (1995) [Pubmed]
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  9. Regulation of ornithine decarboxylase activity by corticotropin in adrenocortical tumor cell clones: roles of cyclic AMP and cyclic AMP-dependent protein kinase. Kudlow, J.E., Rae, P.A., Gutmann, N.S., Schimmer, B.P., Burrow, G.N. Proc. Natl. Acad. Sci. U.S.A. (1980) [Pubmed]
  10. Modulation of T cells by cyclic AMP in murine influenza virus infection. I. In vitro inhibition of cytotoxic T lymphocytes by exogenous cyclic AMP analogues and by agents which increase intracellular cyclic AMP concentrations. Zhang, Y.H., Mak, N.K., Leung, K.N., Hunt, N.H. Immunopharmacology (1987) [Pubmed]
  11. Interaction between glucocorticoids, 8-bromoadenosine 3',5'-monophosphate, and insulin in regulation of synthesis of carbamoyl-phosphate synthetase I in Reuber hepatoma H-35. Kitagawa, Y., Sugimoto, E. Eur. J. Biochem. (1985) [Pubmed]
  12. Depolarizing agents and cyclic nucleotides regulate the phosphorylation of specific neuronal proteins in rat cerebral cortex slices. Forn, J., Greengard, P. Proc. Natl. Acad. Sci. U.S.A. (1978) [Pubmed]
  13. Downregulation of CIITA function by protein kinase a (PKA)-mediated phosphorylation: mechanism of prostaglandin E, cyclic AMP, and PKA inhibition of class II major histocompatibility complex expression in monocytic lines. Li, G., Harton, J.A., Zhu, X., Ting, J.P. Mol. Cell. Biol. (2001) [Pubmed]
  14. 8-Bromo-cyclic AMP induces phosphorylation of two sites in SRC-1 that facilitate ligand-independent activation of the chicken progesterone receptor and are critical for functional cooperation between SRC-1 and CREB binding protein. Rowan, B.G., Garrison, N., Weigel, N.L., O'Malley, B.W. Mol. Cell. Biol. (2000) [Pubmed]
  15. Activin a signaling induces Smad2, but not Smad3, requiring protein kinase a activity in granulosa cells from the avian ovary. Schmierer, B., Schuster, M.K., Shkumatava, A., Kuchler, K. J. Biol. Chem. (2003) [Pubmed]
  16. Cyclic AMP-dependent regulation of the number of [3H]batrachotoxinin benzoate binding sites on rat cardiac myocytes. Taouis, M., Sheldon, R.S., Hill, R.J., Duff, H.J. J. Biol. Chem. (1991) [Pubmed]
  17. Structure of the gene encoding VGF, a nervous system-specific mRNA that is rapidly and selectively induced by nerve growth factor in PC12 cells. Salton, S.R., Fischberg, D.J., Dong, K.W. Mol. Cell. Biol. (1991) [Pubmed]
  18. E-cadherin expression during the differentiation of human trophoblasts. Coutifaris, C., Kao, L.C., Sehdev, H.M., Chin, U., Babalola, G.O., Blaschuk, O.W., Strauss, J.F. Development (1991) [Pubmed]
  19. Evidence for a presynaptic adenylate cyclase system facilitating [3H]norepinephrine release from rat brain neocortex slices and synaptosomes. Schoffelmeer, A.N., Hogenboom, F., Mulder, A.H. J. Neurosci. (1985) [Pubmed]
  20. Control of HLA-DR antigen expression by gamma-interferon: separate signal transduction mechanisms in malignant and nonmalignant human thyroid cells. Lahat, N., Sobel, E., Kraiem, Z. Cancer Res. (1993) [Pubmed]
  21. Regulation of low density lipoprotein receptor synthesis in cultured luteinized human granulosa cells by human chorionic gonadotropin and 8-bromo-cyclic AMP. Golos, T.G., Strauss, J.F. J. Biol. Chem. (1985) [Pubmed]
  22. Cyclic AMP-modulated phosphorylation of intermediate filament proteins in cultured avian myogenic cells. Gard, D.L., Lazarides, E. Mol. Cell. Biol. (1982) [Pubmed]
  23. Evidence for the presence of cholesterol side chain cleavage cytochrome P-450 and adrenodoxin in fresh granulosa cells. Effects of follicle-stimulating hormone and cyclic AMP on cholesterol side chain cleavage cytochrome P-450 synthesis and activity. Funkenstein, B., Waterman, M.R., Masters, B.S., Simpson, E.R. J. Biol. Chem. (1983) [Pubmed]
  24. Atrial natriuretic peptide and cyclic nucleotides affect glucose-induced Ca2+ responses in single pancreatic islet beta-cells: correlation with (Ca[2+] + Mg2+)-ATPase activity. Lee, B., Laychock, S.G. Diabetes (1997) [Pubmed]
  25. Induction of synthesis of cholesterol side chain cleavage cytochrome P-450 and adrenodoxin by follicle-stimulating hormone, 8-bromo-cyclic AMP, and low density lipoprotein in cultured bovine granulosa cells. Funkenstein, B., Waterman, M.R., Simpson, E.R. J. Biol. Chem. (1984) [Pubmed]
  26. The role of cyclic AMP in aldosterone production by isolated zona glomerulosa cells. Fujita, K., Aguilera, G., Catt, K.J. J. Biol. Chem. (1979) [Pubmed]
  27. ATP-binding cassette transporter A1 mediates cellular secretion of alpha-tocopherol. Oram, J.F., Vaughan, A.M., Stocker, R. J. Biol. Chem. (2001) [Pubmed]
  28. Interferon-gamma inhibits thyrotropin-induced thyroidal peroxidase gene expression in cultured human thyrocytes. Ashizawa, K., Yamashita, S., Nagayama, Y., Kimura, H., Hirayu, H., Izumi, M., Nagataki, S. J. Clin. Endocrinol. Metab. (1989) [Pubmed]
  29. Cyclic AMP potentiation of cytokine-induced nitric oxide synthase activity in a murine astrocyte cell line. Burgher, K.L., Heroux, J.A., Ringheim, G.E. Neurochem. Int. (1997) [Pubmed]
  30. Nitric oxide activates extracellular signal-regulated kinase 1/2 and enhances declustering of ionotropic glutamate receptor subunit 2/3 in rat cerebellar Purkinje cells. Endo, S., Launey, T. Neurosci. Lett. (2003) [Pubmed]
  31. Retinoic acid inhibits human thyroid peroxidase and thyroglobulin gene expression in cultured human thyrocytes. Namba, H., Yamashita, S., Morita, S., Villadolid, M.C., Kimura, H., Yokoyama, N., Izumi, M., Ishikawa, N., Ito, K., Nagataki, S. J. Endocrinol. Invest. (1993) [Pubmed]
  32. Mechanism for the antitumor and anticachectic effects of n-3 fatty acids. Sauer, L.A., Dauchy, R.T., Blask, D.E. Cancer Res. (2000) [Pubmed]
  33. Natriuretic peptide clearance receptor is transcriptionally down-regulated by beta 2-adrenergic stimulation in vascular smooth muscle cells. Kishimoto, I., Yoshimasa, T., Suga, S., Ogawa, Y., Komatsu, Y., Nakagawa, O., Itoh, H., Nakao, K. J. Biol. Chem. (1994) [Pubmed]
  34. Adrenocortical function of the domestic fowl: effects of orchiectomy and androgen replacement. Carsia, R.V., Reisch, N.M., Fennell, M.J., Weber, H. Proc. Soc. Exp. Biol. Med. (1987) [Pubmed]
  35. Glucocorticoid receptors in bovine adrenal medullary cells in culture: regulation by cyclic nucleotides. Betito, K., Diorio, J., Meaney, M.J., Boksa, P. Neuroscience (1993) [Pubmed]
  36. Cyclic AMP derivatives injected into the inferior colliculus induce audiogenic seizure-like phenomena in normal rats. Ludvig, N., Moshé, S.L. Brain Res. (1987) [Pubmed]
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