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Gene Review

INHA  -  inhibin, alpha

Homo sapiens

Synonyms: Inhibin alpha chain
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Disease relevance of INHA

  • The data demonstrate that promoter methylation is associated with downregulation of the INHA gene in prostate cancer cell lines, which is consistent with its tumour suppressive role [1].
  • Whereas non-malignant regions of human primary prostate carcinomas express inhibin alpha-subunit (INHA), malignant tissues lack INHA transcript and protein, which is consistent with epigenetic regulation of the inhibin alpha-subunit gene (INHA) promoter [1].
  • To investigate the expression of MMPs and the correlation between the expression of MMPs and angiogenesis in colorectal adenocarcinoma, we studied 72 cases of colorectal adenocarcinoma in Inha University Hospital from 1996 to 1997 [2].

High impact information on INHA


Biological context of INHA

  • We conclude that the inheritance of specific INHA promoter haplotypes predispose to the development of premature ovarian failure [4].
  • Methylation of the promoter was revealed by bisulphite genomic sequencing and use of inhibitors of methylation and histone deacetylation resulted in reactivation of the INHA transcription and translation [1].
  • Mapping placed the INHA gene in close proximity to D2S2848 (SHGC11864) with a log of odds (LOD) score of 5.84 [5].
  • Six patients were heterozygous for three INHA mutations: one in exon 1, 127C>G, and two in exon 2, 3998G>A and 4088G>A, all leading to amino acid substitutions (P43A, G227R, and A257T, respectively) [5].
  • We first mapped the INHA gene by radiation hybrid analysis and determined 10 linked microsatellite markers in an area flanked by D2S1371 and D2S206 on 2q33-qter [5].

Other interactions of INHA


Analytical, diagnostic and therapeutic context of INHA

  • We retrospectively reviewed by questionnaire SEP cases among CAPD patients from 7 university hospital dialysis centers in Korea, including Yonsei University, Ajou University, Catholic University, Inha University, Kyungpook University, Seoul National University and Soonchunhyang University, from January 1981 to December 2002 [7].


  1. Epigenetic regulation of inhibin alpha-subunit gene in prostate cancer cell lines. Balanathan, P., Ball, E.M., Wang, H., Harris, S.E., Shelling, A.N., Risbridger, G.P. J. Mol. Endocrinol. (2004) [Pubmed]
  2. Correlation between expression of matrix metalloproteinase-2 (MMP-2), and matrix metalloproteinase-9 (MMP-9) and angiogenesis in colorectal adenocarcinoma. Kim, T.S., Kim, Y.B. J. Korean Med. Sci. (1999) [Pubmed]
  3. Localization of the t(2;13) breakpoint of alveolar rhabdomyosarcoma on a physical map of chromosome 2. Barr, F.G., Holick, J., Nycum, L., Biegel, J.A., Emanuel, B.S. Genomics (1992) [Pubmed]
  4. INHA promoter polymorphisms are associated with premature ovarian failure. Harris, S.E., Chand, A.L., Winship, I.M., Gersak, K., Nishi, Y., Yanase, T., Nawata, H., Shelling, A.N. Mol. Hum. Reprod. (2005) [Pubmed]
  5. Inhibin alpha-subunit (INHA) gene and locus changes in paediatric adrenocortical tumours from TP53 R337H mutation heterozygote carriers. Longui, C.A., Lemos-Marini, S.H., Figueiredo, B., Mendonca, B.B., Castro, M., Liberatore, R., Watanabe, C., Lancellotti, C.L., Rocha, M.N., Melo, M.B., Monte, O., Calliari, L.E., Guerra-Junior, G., Baptista, M.T., Sbragia-Neto, L., Latronico, A.C., Moreira, A., Tardelli, A.M., Nigri, A., Taymans, S.E., Stratakis, C.A. J. Med. Genet. (2004) [Pubmed]
  6. Aminopeptidase-N from the Helicoverpa armigera (Hubner) brush border membrane vesicles as a receptor of Bacillus thuringiensis crylac delta-endotoxin. Ingle, S.S., Trivedi, N., Prasad, R., Kuruvilla, J., Rao, K.K., Chhatpar, H.S. Curr. Microbiol. (2001) [Pubmed]
  7. Clinical characteristics of dialysis related sclerosing encapsulating peritonitis: multi-center experience in Korea. Kim, B.S., Choi, H.Y., Ryu, D.R., Yoo, T.H., Park, H.C., Kang, S.W., Choi, K.H., Ha, S.K., Han, D.S., Lee, H.Y. Yonsei Med. J. (2005) [Pubmed]
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