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Gene Review

Inha  -  inhibin alpha

Rattus norvegicus

Synonyms: Inhibin alpha chain
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Disease relevance of Inha

  • However, because of the significant decrease in total RNA levels per testis caused by cryptorchidism, the absolute change in inhibin-alpha subunit mRNA levels per testis corresponded to an approximately 3-fold decrease.(ABSTRACT TRUNCATED AT 400 WORDS)[1]
  • Wilms' tumor protein WT1 as an ovarian transcription factor: decreases in expression during follicle development and repression of inhibin-alpha gene promoter [2].
  • Strong expression of the inhibin alpha-subunit in Sertoli cells of untreated and control rats was observed; this subunit was undetectable or poorly detectable in rats with orchitis [3].
  • Our findings indicate that messenger RNAs encoding inhibin alpha- and beta A-subunits and activin receptors I, II, and IIB were expressed, and inhibin/activin proteins were produced, by GH3 cells, imply that these gonadal growth factors may have paracrine/autocrine functions in rat pituitary adenocarcinoma [4].

High impact information on Inha

  • In addition to the ovary and testis, inhibin alpha, beta A, and beta B RNAs were detected in the placenta, pituitary, adrenal, bone marrow, kidney, spinal cord, and brain [5].
  • Furthermore, the presence of inhibin alpha and beta subunits in the placenta and the pituitary gland, two cell types that have clearly been shown to be regulated by exogenous inhibin, may reflect existing paracrine and/or autocrine processes active in these tissues [5].
  • Finally, we find that the FSH-mediated up-regulation of reporter activities for LHR, inhibin-alpha, and vascular endothelial growth factor is dependent upon HIF-1 activity, because a dominant negative form of HIF-1alpha interferes with the up-regulation of these genes [6].
  • In this study we examined the expression and regulation of the CREM gene in the rat ovary and in granulosa cells, to determine whether repressor isoforms of CREM might have a role in the LH-mediated suppression of inhibin alpha-subunit gene expression that occurs just before ovulation [7].
  • Gonadotropins regulate inducible cyclic adenosine 3',5'-monophosphate early repressor in the rat ovary: implications for inhibin alpha subunit gene expression [7].

Biological context of Inha


Anatomical context of Inha

  • On the other hand, hybridization signals for the inhibin alpha-subunit were observed in some small antral and preantral size follicles, while signals were very low or undetectable in a large number of atretic follicles [9].
  • Moreover, in situ hybridization analysis demonstrated that the increased expression of inhibin-alpha and -betaB mRNAs observed 5 days after EDS takes place mainly in Sertoli cells [12].
  • The expression of activin type II and IIB receptors and inhibin alpha-, beta A-, and beta B-subunit messenger RNAs (mRNAs), and the secretion of immunoreactive and bioactive activin during culture of testicular peritubular myoid cells and peritubular myoid cell lines were studied [13].
  • Follicle-stimulating hormone regulation of inhibin alpha-subunit mRNA in staged rat seminiferous tubules [14].
  • When Sertoli cells were co-cultured with pachytene spermatocytes, inhibin alpha-subunit secretion was unaltered, while inhibin B secretion was suppressed in a cell concentration-dependent manner to reach a maximal suppression of 45% compared with Sertoli cells alone (P<0.01) [15].

Associations of Inha with chemical compounds

  • Similarly, the expression of inhibin alpha-subunit mRNA was increased following FSH stimulation, whereas testosterone had no effect [16].
  • Maximal stimulation of the inhibin-alpha mRNA level was achieved with 100 micrograms/l FSH, dibutyryl-3',5'-cyclic adenosine monophosphate (db-cAMP, 0.2 mmol/l) and Sp-adenosine-3',5'-monophosphothionate (Sp-cAMPS, 10 mumol/l) (a cAMP agonist) [14].
  • Actinomycin D abolished the stimulatory effect of FSH on inhibin-alpha mRNA expression [14].
  • Tamoxifen showed completely opposite effects to estradiol, and a combination of estradiol and tamoxifen resulted in similar levels of inhibin-alpha and -beta A mRNAs to the control [17].
  • A high dose of PMSG (160-500 mU mL-1) clearly suppressed inhibin alpha mRNA levels as well as inhibin secretion, whereas progesterone (P) was maximally stimulated (up to 600 fold) [18].

Other interactions of Inha


Analytical, diagnostic and therapeutic context of Inha


  1. Possible involvement of inhibin in altered follicle-stimulating hormone (FSH) secretion during dissociated luteinizing hormone (LH) and FSH release: unilateral castration and experimental cryptorchidism. Rivier, C., Meunier, H., Roberts, V., Vale, W. Biol. Reprod. (1989) [Pubmed]
  2. Wilms' tumor protein WT1 as an ovarian transcription factor: decreases in expression during follicle development and repression of inhibin-alpha gene promoter. Hsu, S.Y., Kubo, M., Chun, S.Y., Haluska, F.G., Housman, D.E., Hsueh, A.J. Mol. Endocrinol. (1995) [Pubmed]
  3. Correlation between inhibin secretion and damage of seminiferous tubules in a model of experimental autoimmune orchitis. Suescun, M.O., Suescun, M.O., Lustig, L., Calandra, R.S., Calandra, R.S., Groome, N.P., Campo, S. J. Endocrinol. (2001) [Pubmed]
  4. Expression and localization of inhibin/activin and activin receptors in GH3 cells, a rat pituitary adenocarcinoma cell line. Ying, C., Zhang, Z., Huang, G., Li, S.Q., Ying, S.Y. J. Endocrinol. Invest. (1996) [Pubmed]
  5. Gonadal and extragonadal expression of inhibin alpha, beta A, and beta B subunits in various tissues predicts diverse functions. Meunier, H., Rivier, C., Evans, R.M., Vale, W. Proc. Natl. Acad. Sci. U.S.A. (1988) [Pubmed]
  6. Follicle-stimulating hormone activation of hypoxia-inducible factor-1 by the phosphatidylinositol 3-kinase/AKT/Ras homolog enriched in brain (Rheb)/mammalian target of rapamycin (mTOR) pathway is necessary for induction of select protein markers of follicular differentiation. Alam, H., Maizels, E.T., Park, Y., Ghaey, S., Feiger, Z.J., Chandel, N.S., Hunzicker-Dunn, M. J. Biol. Chem. (2004) [Pubmed]
  7. Gonadotropins regulate inducible cyclic adenosine 3',5'-monophosphate early repressor in the rat ovary: implications for inhibin alpha subunit gene expression. Mukherjee, A., Urban, J., Sassone-Corsi, P., Mayo, K.E. Mol. Endocrinol. (1998) [Pubmed]
  8. Repression of the inhibin alpha-subunit gene by the transcription factor CCAAT/enhancer-binding protein-beta. Burkart, A.D., Mukherjee, A., Sterneck, E., Johnson, P.F., Mayo, K.E. Endocrinology (2005) [Pubmed]
  9. Periovulatory changes in the expression of inhibin alpha-, beta A-, and beta B-subunits in hormonally induced immature female rats. Meunier, H., Roberts, V.J., Sawchenko, P.E., Cajander, S.B., Hsueh, A.J., Vale, W. Mol. Endocrinol. (1989) [Pubmed]
  10. Transcriptional regulation of inhibin beta B messenger ribonucleic acid levels in TM.4 or primary rat Sertoli cells by 8-bromo-cyclic adenosine monophosphate. Najmabadi, H., Rosenberg, L.A., Yuan, Q.X., Reyaz, G., Bhasin, S. Mol. Endocrinol. (1993) [Pubmed]
  11. Inhibin: studies of stored and secreted forms by biosynthetic labeling and immunodetection in cultured rat granulosa cells. Bicsak, T.A., Cajander, S.B., Vale, W., Hsueh, A.J. Endocrinology (1988) [Pubmed]
  12. The pattern of inhibin/activin alpha- and betaB-subunit messenger ribonucleic acid expression in rat testis after selective Leydig cell destruction by ethylene dimethane sulfonate. Tena-Sempere, M., Kero, J., Rannikko, A., Yan, W., Huhtaniemi, I. Endocrinology (1999) [Pubmed]
  13. Peritubular myoid cells from immature rat testes secrete activin-A and express activin receptor type II in vitro. de Winter, J.P., Vanderstichele, H.M., Verhoeven, G., Timmerman, M.A., Wesseling, J.G., de Jong, F.H. Endocrinology (1994) [Pubmed]
  14. Follicle-stimulating hormone regulation of inhibin alpha-subunit mRNA in staged rat seminiferous tubules. Kaipia, A., Penttilä, T.L., Toppari, J. Eur. J. Endocrinol. (1994) [Pubmed]
  15. Pachytene spermatocytes in co-culture inhibit rat Sertoli cell synthesis of inhibin beta B-subunit and inhibin B but not the inhibin alpha-subunit. Clifton, R.J., O'Donnell, L., Robertson, D.M. J. Endocrinol. (2002) [Pubmed]
  16. Effects of FSH and testosterone on highly purified rat Sertoli cells: inhibin alpha-subunit mRNA expression and inhibin secretion are enhanced by FSH but not by testosterone. Toebosch, A.M., Robertson, D.M., Klaij, I.A., de Jong, F.H., Grootegoed, J.A. J. Endocrinol. (1989) [Pubmed]
  17. Direct effects of estradiol and tamoxifen on gene expressions of inhibit alpha- and beta A-subunits in rat granulosa cells in vitro. Tate, S., Suganuma, N., Furuhashi, M., Ando, T., Asada, Y., Kondo, I., Kikkawa, F., Tomoda, Y. Endocr. J. (1996) [Pubmed]
  18. The biphasic modulation of inhibin mRNA levels and secretion by PMSG in rat granulosa cells in vitro. Michel, U., Krozowski, Z., McMaster, J., Yu, J.H., Findlay, J.K. Reprod. Fertil. Dev. (1991) [Pubmed]
  19. Immunostainable inhibin subunits are in multiple types of testicular cells. Shaha, C., Morris, P.L., Chen, C.L., Vale, W., Bardin, C.W. Endocrinology (1989) [Pubmed]
  20. Developmental expression of testis messenger ribonucleic acids in the rat following propylthiouracil-induced neonatal hypothyroidism. Bunick, D., Kirby, J., Hess, R.A., Cooke, P.S. Biol. Reprod. (1994) [Pubmed]
  21. Localization and cellular sources of activins in normal and fibrotic rat liver. De Bleser, P.J., Niki, T., Xu, G., Rogiers, V., Geerts, A. Hepatology (1997) [Pubmed]
  22. Regulation of inhibin beta B-subunit mRNA expression in rat Sertoli cells: consequences for the production of bioactive and immunoreactive inhibin. Klaij, I.A., Timmerman, M.A., Blok, L.J., Grootegoed, J.A., de Jong, F.H. Mol. Cell. Endocrinol. (1992) [Pubmed]
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