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Gene Review

CRISP1  -  cysteine-rich secretory protein 1

Homo sapiens

Synonyms: AEG-like protein, AEGL1, ARP, Acidic epididymal glycoprotein homolog, CRISP-1, ...
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Disease relevance of CRISP1

  • ARP exacerbations were associated with significantly higher plasma levels of the inflammatory marker soluble intracellular adhesion molecule 1 than non-ARP exacerbations, indicating relatively enhanced immune activation during ARP relapses [1].
  • The absolute (ARP) and relative refractory period (RRP) of the median sensory nerve was determined in 26 control subjects and 24 alcoholics, nine of whom had symptoms of peripheral neuropathy [2].
  • Our studies on the relationships among the lymphoid system, apoptosis and apoptosis-related proteins (ARP) in human ovarian benign cysts, borderline tumors, and carcinomas are reviewed and analyzed [3].
  • CONCLUSION: Plasma levels of AVP, Aldo, and ARP increase during exercise when a threshold is reached and thereafter are dependent on the absolute workload, without any specific effect of hypoxia [4].
  • Human APOBEC3G (hA3G) is a member of the APOBEC-1 related protein (ARP) family of cytidine deaminases. hA3G functions as a natural defense against endogenous retrotransposons and a multitude of retroviruses, most notably human immunodeficiency virus type 1 (HIV-1) [5].

Psychiatry related information on CRISP1

  • Biological and developmental vulnerabilities, maladaptive learning experiences, and pathological family patterns may all contribute to the appearance and persistence of eating disorder (Bruch 1973, Crisp 1980, Garfinkel and Garner 1982) [6].
  • Scores on the Crown Crisp Experimental Index indicate a significant difference in the profiles of somatization and hysteria [7].
  • The subtleties of diagnosing anorexia nervosa have recently been recognized in this group (e.g. Cottrell & Crisp, 1984) [8].
  • Psychological theories of aetiology are discussed with reference to Bruch, Crisp, Palazzoli and Minuchin: the common theme is the reaction of the patient and her family to the physical and social changes of puberty [9].
  • Initial interest in the relationship between eating disorders, which occur primarily in women, and substance abuse, which is much more frequent in men than women, stemmed from the observations of Crisp (1968) who noted that chronic anorexics who developed bulimic behavior often abused alcohol [10].

High impact information on CRISP1

  • We amplified and sequenced the multiple arginine coding area of the ARP gene in primary head and neck, non-small cell lung, and renal cell cancers [11].
  • The arginine-rich protein (ARP) gene was recently cloned and localized to human chromosome band 3p21 [11].
  • Thus, the variations in the ARP trinucleotide repeat region represent normal polymorphisms rather than tumor-specific mutations [11].
  • Physiologically relevant ARP26)levels promoted AChE gene expression and induced the expansion of cultured CD34+ progenitors and granulocyte maturation more effectively than cortisol, suggesting autoregulatory prolongation of ARP effects [12].
  • A high-quality multiple alignment of approximately 700 complete protein sequences homologous to actin, including 148 ARP sequences, allowed us to extend the ARP classification to new organisms [13].

Biological context of CRISP1

  • Mammalian members of the cysteine-rich secretory protein (CRISP) family are expressed predominantly in the male reproductive tract and are implicated in the process of reproduction from spermiogenesis, posttesticular sperm maturation, and capacitation to oocyte-sperm fusion, and possibly also penetration of the zona pellucida [14].
  • 2. This result indicates that AEGL1 and the mouse gene for AEG are located in the chromosomal segments with conserved syntenies [15].
  • The amino acid sequence predicted from the complete nucleotide sequence of this clone is remarkable because 40% of the residues are Asn, and so the antigen has been termed the Asparagine-Rich Protein (ARP) [16].
  • The interesting finding that the binding site of DE resides in an evolutionarily conserved region of the molecule provides novel information on the molecular mechanisms underlying CRISP-1 function in gamete fusion with important implications on the structure-function relationship of other members of the widely distributed CRISP family [17].
  • Kinetic studies of ARP phosphorylation during germination revealed a specific order of phospho-ARP appearance, suggesting that this process is under regulation within this period [18].

Anatomical context of CRISP1


Associations of CRISP1 with chemical compounds

  • Characterization of a human glycoprotein with a potential role in sperm-egg fusion: cDNA cloning, immunohistochemical localization, and chromosomal assignment of the gene (AEGL1) [15].
  • In the context of the CRISP promoters a 2-fold induction by R1881 was measured for the CRISP-3 upstream region whereas only limited effects were noted for the CRISP-1 upstream region [23].
  • The most striking finding was that recurrent infections, both in LE patients and in those with CBFP reactions and widespread, acral discoid skin lesions, occurred significantly more often in ARP-positive patients [24].
  • The acquisition of symmetry axes in the emerging leaf is a process coordinated by hormones (such as auxin and cytokinins) and the expression of classes of genes (such as the knox and the ARP, as1/rs2/phan, genes) [25].
  • By the use of ARP assay detecting abasic sites in DNA, we first investigated the activity on the natural DNA substrates containing methylpurines, ethenopurines, or hypoxanthine (Hx) prepared by the conventional methods [26].

Other interactions of CRISP1


Analytical, diagnostic and therapeutic context of CRISP1


  1. Prospective study on the relationship between infections and multiple sclerosis exacerbations. Buljevac, D., Flach, H.Z., Hop, W.C., Hijdra, D., Laman, J.D., Savelkoul, H.F., van Der Meché, F.G., van Doorn, P.A., Hintzen, R.Q. Brain (2002) [Pubmed]
  2. Relative refractory period: a measure to detect early neuropathy in alcoholics. Alderson, M.K., Petajan, J.H. Muscle Nerve (1987) [Pubmed]
  3. The immune system, apoptosis and apoptosis-related proteins in human ovarian tumors (a review). Zusman, I., Gurevich, P., Gurevich, E., Ben-Hur, H. Int. J. Oncol. (2001) [Pubmed]
  4. Fluid-regulatory hormone responses during cycling exercise in acute hypobaric hypoxia. Bocqueraz, O., Koulmann, N., Guigas, B., Jimenez, C., Melin, B. Medicine and science in sports and exercise. (2004) [Pubmed]
  5. APOBEC-1 and AID are nucleo-cytoplasmic trafficking proteins but APOBEC3G cannot traffic. Bennett, R.P., Diner, E., Sowden, M.P., Lees, J.A., Wedekind, J.E., Smith, H.C. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
  6. Psychosocial treatments for eating disorders. Yager, J. Psychiatry. (1994) [Pubmed]
  7. Evaluation of the psychological profiles of patients with signs and symptoms of temporomandibular disorders. Zach, G.A., Andreasen, K. The Journal of prosthetic dentistry. (1991) [Pubmed]
  8. The music therapy of an anorectic mentally handicapped adult. Heal, M., O'Hara, J. The British journal of medical psychology. (1993) [Pubmed]
  9. Anorexia nervosa--diagnosis, aetiology, and treatment. Hartman, D. Postgraduate medical journal. (1995) [Pubmed]
  10. The relationship of eating disorders and substance abuse. Krahn, D.D. Journal of substance abuse. (1991) [Pubmed]
  11. Normal polymorphism in the incomplete trinucleotide repeat of the arginine-rich protein gene. Evron, E., Cairns, P., Halachmi, N., Ahrendt, S.A., Reed, A.L., Sidransky, D. Cancer Res. (1997) [Pubmed]
  12. Hydrolytic and nonenzymatic functions of acetylcholinesterase comodulate hemopoietic stress responses. Grisaru, D., Pick, M., Perry, C., Sklan, E.H., Almog, R., Goldberg, I., Naparstek, E., Lessing, J.B., Soreq, H., Deutsch, V. J. Immunol. (2006) [Pubmed]
  13. Sequence and comparative genomic analysis of actin-related proteins. Muller, J., Oma, Y., Vallar, L., Friederich, E., Poch, O., Winsor, B. Mol. Biol. Cell (2005) [Pubmed]
  14. Characterization and localization of cysteine-rich secretory protein 3 (CRISP-3) in the human male reproductive tract. Udby, L., Bjartell, A., Malm, J., Egesten, A., Lundwall, A., Cowland, J.B., Borregaard, N., Kjeldsen, L. J. Androl. (2005) [Pubmed]
  15. Characterization of a human glycoprotein with a potential role in sperm-egg fusion: cDNA cloning, immunohistochemical localization, and chromosomal assignment of the gene (AEGL1). Hayashi, M., Fujimoto, S., Takano, H., Ushiki, T., Abe, K., Ishikura, H., Yoshida, M.C., Kirchhoff, C., Ishibashi, T., Kasahara, M. Genomics (1996) [Pubmed]
  16. An asparagine-rich protein from blood stages of Plasmodium falciparum shares determinants with sporozoites. Stahl, H.D., Bianco, A.E., Crewther, P.E., Burkot, T., Coppel, R.L., Brown, G.V., Anders, R.F., Kemp, D.J. Nucleic Acids Res. (1986) [Pubmed]
  17. Sperm protein "DE" mediates gamete fusion through an evolutionarily conserved site of the CRISP family. Ellerman, D.A., Cohen, D.J., Da Ros, V.G., Morgenfeld, M.M., Busso, D., Cuasnicú, P.S. Dev. Biol. (2006) [Pubmed]
  18. Regulation of acidic ribosomal protein expression and phosphorylation in maize. Montoya-García, L., Muñoz-Ocotero, V., Aguilar, R., Sánchez de Jiménez, E. Biochemistry (2002) [Pubmed]
  19. Evidence that human epididymal protein ARP plays a role in gamete fusion through complementary sites on the surface of the human egg. Cohen, D.J., Ellerman, D.A., Busso, D., Morgenfeld, M.M., Piazza, A.D., Hayashi, M., Young, E.T., Kasahara, M., Cuasnicu, P.S. Biol. Reprod. (2001) [Pubmed]
  20. An ELISA for SGP28/CRISP-3, a cysteine-rich secretory protein in human neutrophils, plasma, and exocrine secretions. Udby, L., Cowland, J.B., Johnsen, A.H., Sørensen, O.E., Borregaard, N., Kjeldsen, L. J. Immunol. Methods (2002) [Pubmed]
  21. Preferential expression of cystein-rich secretory protein-3 (CRISP-3) in chronic pancreatitis. Liao, Q., Kleeff, J., Xiao, Y., Guweidhi, A., Schambony, A., Töpfer-Petersen, E., Zimmermann, A., Büchler, M.W., Friess, H. Histol. Histopathol. (2003) [Pubmed]
  22. Characterization of a novel ADP-ribosylation factor-like protein (yARL3) in Saccharomyces cerevisiae. Huang, C.F., Buu, L.M., Yu, W.L., Lee, F.J. J. Biol. Chem. (1999) [Pubmed]
  23. Androgen receptor signalling: comparative analysis of androgen response elements and implication of heat-shock protein 90 and 14-3-3eta. Haendler, B., Schüttke, I., Schleuning, W.D. Mol. Cell. Endocrinol. (2001) [Pubmed]
  24. Antibodies to retroviral proteins in autoimmune connective tissue disease. Relation to clinical manifestations and ribonucleoprotein autoantibodies. Ranki, A., Kurki, P., Riepponen, S., Stephansson, E. Arthritis Rheum. (1992) [Pubmed]
  25. Patterns and symmetries in leaf development. Pozzi, C., Rossini, L., Agosti, F. Semin. Cell Dev. Biol. (2001) [Pubmed]
  26. Substrate specificity of human methylpurine DNA N-glycosylase. Asaeda, A., Ide, H., Asagoshi, K., Matsuyama, S., Tano, K., Murakami, A., Takamori, Y., Kubo, K. Biochemistry (2000) [Pubmed]
  27. Human testicular protein TPX1/CRISP-2: localization in spermatozoa, fate after capacitation and relevance for gamete interaction. Busso, D., Cohen, D.J., Hayashi, M., Kasahara, M., Cuasnicú, P.S. Mol. Hum. Reprod. (2005) [Pubmed]
  28. Aminopeptidase-N from the Helicoverpa armigera (Hubner) brush border membrane vesicles as a receptor of Bacillus thuringiensis crylac delta-endotoxin. Ingle, S.S., Trivedi, N., Prasad, R., Kuruvilla, J., Rao, K.K., Chhatpar, H.S. Curr. Microbiol. (2001) [Pubmed]
  29. Individual psychotherapy for children and adolescents with an eating disorder from historical precedent toward evidence-based practice. McDermott, B.M., Harris, C., Gibbon, P. Child and adolescent psychiatric clinics of North America. (2002) [Pubmed]
  30. Choice menus will serve up more private sector options. McLellan, A. The Health service journal. (2005) [Pubmed]
  31. Purification, crystallization and preliminary X-ray crystallographic analysis of a cysteine-rich secretory protein (CRISP) from Naja atra venom. Wang, Y.L., Goh, K.X., Wu, W.G., Chen, C.J. Acta Crystallogr. D Biol. Crystallogr. (2004) [Pubmed]
  32. A comparative study of peroxidases from horse radish and Arthromyces ramosus as labels in luminol-mediated chemiluminescent assays. Kim, B.B., Pisarev, V.V., Egorov, A.M. Anal. Biochem. (1991) [Pubmed]
  33. The enigma of cell death in neurodegenerative disorders. Jellinger, K.A., Stadelmann, C.H. J. Neural Transm. Suppl. (2000) [Pubmed]
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