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Gene Review

Inha  -  inhibin alpha

Mus musculus

Synonyms: AW555078, Inhibin alpha chain
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Disease relevance of Inha


Psychiatry related information on Inha


High impact information on Inha

  • In mouse Sertoli cells, transcription of the Inha gene encoding the alpha subunit of inhibin, which acts locally as a tumor suppressor, is down-regulated in tumors and in normal cells during aging [7].
  • In a Sertoli tumor cell line in which expression of both Inha and Rnf6 was reduced, reexpression of the latter restored the level of Inha while, concomitantly, the cells reverted to normal growth control in culture [7].
  • In transient and stable transfectants, Rnf6 expression from a heterologous promoter increased the expression of reporter genes driven by the Inha promoter [7].
  • Expression of the inhibin alpha chain could not be detected in embryonic or extraembryonic tissues at any of the stages studied (5.5 to 8.5 days) and expression of the beta A and beta B subunits could only be observed in the deciduum in cells surrounding the embryo [8].
  • Immunization of SWXJ female mice with the p215-234 peptide derived from mouse inhibin-alpha activates CD4(+) T cells and induces experimental autoimmune oophoritis with a unique biphasic phenotype characterized by an early stage of enhanced fertility followed by a delayed stage of POF [9].

Chemical compound and disease context of Inha


Biological context of Inha


Anatomical context of Inha


Associations of Inha with chemical compounds


Regulatory relationships of Inha


Other interactions of Inha

  • We found that double-knockout females lacking cyclin D2 and Inhalpha lived longer than mice lacking inhibins alone; the majority of these double-knockout mice lived longer than 17 wk, as opposed to inhibin alpha single-knockout females with 50% survival at between 12 and 13 wk of age [16].
  • Although both wild-type and Inha-/- mice display this pattern, only Inha-/- mice produce tumors composed of these Gata4-positive cells [23].
  • Two of these new marker genes were found very tightly linked to Bcg: Des was located 0.3 +/- 0.3 cM distal from (Vil,Bcg) and 0.3 +/- 0.3 cM proximal to Inha [29].
  • FSHbeta mRNA levels were not significantly higher in the pituitaries of castrated inhibin alpha null mice compared to those in Acvr2 null mice and remained the same in the pituitaries of castrated double mutant mice lacking both inhibin and ACVR2 [17].
  • By making use of restriction fragment length polymorphisms in DNAs from interspecific backcross mice, the cluster could be mapped to a position 5.3 +/- 2.1 cM distal to the Inha locus and the same distance proximal to the Bcl-2 locus [30].

Analytical, diagnostic and therapeutic context of Inha


  1. Interrelationship of growth differentiation factor 9 and inhibin in early folliculogenesis and ovarian tumorigenesis in mice. Wu, X., Chen, L., Brown, C.A., Yan, C., Matzuk, M.M. Mol. Endocrinol. (2004) [Pubmed]
  2. Transgenic mouse models for gonadal tumorigenesis. Rahman, N.A., Kananen Rilianawati, K., Paukku, T., Mikola, M., Markkula, M., Hämäläinen, T., Huhtaniemi, I.T. Mol. Cell. Endocrinol. (1998) [Pubmed]
  3. Identification of an inhibin receptor in gonadal tumors from inhibin alpha-subunit knockout mice. Draper, L.B., Matzuk, M.M., Roberts, V.J., Cox, E., Weiss, J., Mather, J.P., Woodruff, T.K. J. Biol. Chem. (1998) [Pubmed]
  4. Adrenocortical tumorigenesis in transgenic mice expressing the inhibin alpha-subunit promoter/simian virus 40 T-antigen transgene: relationship between ectopic expression of luteinizing hormone receptor and transcription factor GATA-4. Rahman, N.A., Kiiveri, S., Rivero-Müller, A., Levallet, J., Vierre, S., Kero, J., Wilson, D.B., Heikinheimo, M., Huhtaniemi, I. Mol. Endocrinol. (2004) [Pubmed]
  5. Activins and inhibins in endocrine and other tumors. Risbridger, G.P., Schmitt, J.F., Robertson, D.M. Endocr. Rev. (2001) [Pubmed]
  6. Developmental changes in inhibin-alpha gene expression in the mouse testis. Seok, O.S., Ahn, J.M., Mayo, K.E., Cho, B.N. Mol. Cells (2004) [Pubmed]
  7. Gene control in germinal differentiation: RNF6, a transcription regulatory protein in the mouse sertoli cell. Lopez, P., Vidal, F., Martin, L., Lopez-Fernandez, L.A., Rual, J.F., Rosen, B.S., Cuzin, F., Rassoulzadegan, M. Mol. Cell. Biol. (2002) [Pubmed]
  8. Expression of inhibin subunits and follistatin during postimplantation mouse development: decidual expression of activin and expression of follistatin in primitive streak, somites and hindbrain. Albano, R.M., Arkell, R., Beddington, R.S., Smith, J.C. Development (1994) [Pubmed]
  9. Autoimmune targeted disruption of the pituitary-ovarian axis causes premature ovarian failure. Altuntas, C.Z., Johnson, J.M., Tuohy, V.K. J. Immunol. (2006) [Pubmed]
  10. High levels of luteinizing hormone analog stimulate gonadal and adrenal tumorigenesis in mice transgenic for the mouse inhibin-alpha-subunit promoter/Simian virus 40 T-antigen fusion gene. Mikola, M., Kero, J., Nilson, J.H., Keri, R.A., Poutanen, M., Huhtaniemi, I. Oncogene (2003) [Pubmed]
  11. Gonadal pathologies in transgenic mice expressing the rat inhibin alpha-subunit. McMullen, M.L., Cho, B.N., Yates, C.J., Mayo, K.E. Endocrinology (2001) [Pubmed]
  12. Long-term testosterone treatment prevents gonadal and adrenal tumorigenesis of mice transgenic for the mouse inhibin-alpha subunit promoter/simian virus 40 T-antigen fusion gene. Rilianawati, n.u.l.l., Kero, J., Paukku, T., Huhtaniemi, I. J. Endocrinol. (2000) [Pubmed]
  13. Gonadal tumors of mice double transgenic for inhibin-alpha promoter-driven simian virus 40 T-antigen and herpes simplex virus thymidine kinase are sensitive to ganciclovir treatment. Mikola, M.K., Rahman, N.A., Paukku, T.H., Ahtiainen, P.M., Vaskivuo, T.E., Tapanainen, J.S., Poutanen, M., Huhtaniemi, I.T. J. Endocrinol. (2001) [Pubmed]
  14. High-resolution linkage map in the vicinity of the host resistance locus Bcg. Malo, D., Vidal, S.M., Hu, J., Skamene, E., Gros, P. Genomics (1993) [Pubmed]
  15. Inhibin and p27 interact to regulate gonadal tumorigenesis. Cipriano, S.C., Chen, L., Burns, K.H., Koff, A., Matzuk, M.M. Mol. Endocrinol. (2001) [Pubmed]
  16. Cyclin D2 and p27 are tissue-specific regulators of tumorigenesis in inhibin alpha knockout mice. Burns, K.H., Agno, J.E., Sicinski, P., Matzuk, M.M. Mol. Endocrinol. (2003) [Pubmed]
  17. Regulation of FSHbeta and GnRH receptor gene expression in activin receptor II knockout male mice. Kumar, T.R., Agno, J., Janovick, J.A., Conn, P.M., Matzuk, M.M. Mol. Cell. Endocrinol. (2003) [Pubmed]
  18. Genetic engineering to study testicular tumorigenesis. Yan, W., Burns, K.H., Matzuk, M.M. APMIS (2003) [Pubmed]
  19. Characterization of integrin expression in the mouse ovary. Burns, K.H., Owens, G.E., Fernandez, J.M., Nilson, J.H., Matzuk, M.M. Biol. Reprod. (2002) [Pubmed]
  20. Characterization of gonadal sex cord-stromal tumor cell lines from inhibin-alpha and p53-deficient mice: the role of activin as an autocrine growth factor. Shikone, T., Matzuk, M.M., Perlas, E., Finegold, M.J., Lewis, K.A., Vale, W., Bradley, A., Hsueh, A.J. Mol. Endocrinol. (1994) [Pubmed]
  21. Sexually dimorphic roles of steroid hormone receptor signaling in gonadal tumorigenesis. Burns, K.H., Agno, J.E., Chen, L., Haupt, B., Ogbonna, S.C., Korach, K.S., Matzuk, M.M. Mol. Endocrinol. (2003) [Pubmed]
  22. Molecular characterization of the follicle defects in the growth differentiation factor 9-deficient ovary. Elvin, J.A., Yan, C., Wang, P., Nishimori, K., Matzuk, M.M. Mol. Endocrinol. (1999) [Pubmed]
  23. Origin and identity of adrenocortical tumors in inhibin knockout mice: implications for cellular plasticity in the adrenal cortex. Looyenga, B.D., Hammer, G.D. Mol. Endocrinol. (2006) [Pubmed]
  24. Mechanism of repression of the inhibin alpha-subunit gene by inducible 3',5'-cyclic adenosine monophosphate early repressor. Burkart, A.D., Mukherjee, A., Mayo, K.E. Mol. Endocrinol. (2006) [Pubmed]
  25. Diesel exhaust (DE) affects the regulation of testicular function in male Fischer 344 rats. Tsukue, N., Toda, N., Tsubone, H., Sagai, M., Jin, W.Z., Watanabe, G., Taya, K., Birumachi, J., Suzuki, A.K. J. Toxicol. Environ. Health Part A (2001) [Pubmed]
  26. A novel targeted therapy of Leydig and granulosa cell tumors through the luteinizing hormone receptor using a hecate-chorionic gonadotropin beta conjugate in transgenic mice. Bodek, G., Vierre, S., Rivero-Müller, A., Huhtaniemi, I., Ziecik, A.J., Rahman, N.A. Neoplasia (2005) [Pubmed]
  27. Cyclic AMP regulates expression of activin and inhibin subunit mRNAs in the mouse placenta and decidua: a short communication. Yamaguchi, M., Fujii, M., Miyake, A. Eur. J. Endocrinol. (1996) [Pubmed]
  28. Testicular GATA-1 factor up-regulates the promoter activity of rat inhibin alpha-subunit gene in MA-10 Leydig tumor cells. Feng, Z.M., Wu, A.Z., Chen, C.L. Mol. Endocrinol. (1998) [Pubmed]
  29. The host resistance locus Bcg is tightly linked to a group of cytoskeleton-associated protein genes that include villin and desmin. Malo, D., Schurr, E., Epstein, D.J., Vekemans, M., Skamene, E., Gros, P. Genomics (1991) [Pubmed]
  30. Genetic mapping and assignment of a long-range repeat cluster to band D of chromosome 1 in Mus musculus and M. spretus. Traut, W., Seldin, M.F., Winking, H. Cytogenet. Cell Genet. (1992) [Pubmed]
  31. Expression of inhibin alpha-subunit gene during mouse gametogenesis. Tone, S., Katoh, Y., Fujimoto, H., Togashi, S., Yanazawa, M., Kato, Y., Higashinakagawa, T. Differentiation (1990) [Pubmed]
  32. Changes in the reproductive functions of mice due to injection of a plasmid expressing an inhibin alpha-subunit into muscle: a transient transgenic model. Ahn, J.M., Jung, H.K., Cho, C., Choi, D., Mayo, K.E., Cho, B.N. Mol. Cells (2004) [Pubmed]
  33. Gonadectomy permits adrenocortical tumorigenesis in mice transgenic for the mouse inhibin alpha-subunit promoter/simian virus 40 T-antigen fusion gene: evidence for negative autoregulation of the inhibin alpha-subunit gene. Kananen, K., Markkula, M., Mikola, M., Rainio, E.M., McNeilly, A., Huhtaniemi, I. Mol. Endocrinol. (1996) [Pubmed]
  34. Endocrine alterations and signaling changes associated with declining ovarian function and advanced biological aging in follicle-stimulating hormone receptor haploinsufficient mice. Danilovich, N., Javeshghani, D., Xing, W., Sairam, M.R. Biol. Reprod. (2002) [Pubmed]
  35. Establishment of Leydig cell line, TTE1, from transgenic mice harboring temperature-sensitive simian virus 40 large T-antigen gene. Ohta, S., Tabuchi, Y., Yanai, N., Asano, S., Fuse, H., Obinata, M. Arch. Androl. (2002) [Pubmed]
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