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Gene Review

ITIH3  -  inter-alpha-trypsin inhibitor heavy chain 3

Homo sapiens

Synonyms: H3P, ITI heavy chain H3, ITI-HC3, Inter-alpha-inhibitor heavy chain 3, Inter-alpha-trypsin inhibitor heavy chain H3, ...
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Disease relevance of ITIH3


High impact information on ITIH3

  • SHAP potentiates the CD44-mediated leukocyte adhesion to the hyaluronan substratum [2].
  • Leukocytes infiltrated to the synovium were strongly positive for HA, SHAP, and CD44 on their surfaces, suggesting a role for the adhesion-enhancing effect of SHAP in pathogenesis [2].
  • We therefore examined the effect of SHAP on the CD44-HA interaction-mediated lymphocyte adhesion [2].
  • We determined that the human ITIH1, ITIH3, and ITIH4 genes are closely linked within a 45-kilobase pair [3].
  • ITIH3 shares highly conserved exon size and intron-exon borders with other ITI heavy chain genes [3].

Biological context of ITIH3


Anatomical context of ITIH3

  • A supplementary model, relating cell wall curvature and growth rate in the cut-interwhorl, characterizes how the stalk's final dimensions and nearly cylindrical shap may arise [5].

Associations of ITIH3 with chemical compounds

  • BACKGROUND: This analysis was designed to investigate prolactin levels in children and adolescents on long-term risperidone treatment and explore any relationship with side effects hypothetically attributable to prolactin (SHAP) [6].


  1. Tandem orientation of the inter-alpha-trypsin inhibitor heavy chain H1 and H3 genes. Diarra-Mehrpour, M., Bourguignon, J., Sarafan, N., Bost, F., Sesboüé, R., Muschio-Bonnet, F., Martin, J.P. Biochim. Biophys. Acta (1994) [Pubmed]
  2. SHAP potentiates the CD44-mediated leukocyte adhesion to the hyaluronan substratum. Zhuo, L., Kanamori, A., Kannagi, R., Itano, N., Wu, J., Hamaguchi, M., Ishiguro, N., Kimata, K. J. Biol. Chem. (2006) [Pubmed]
  3. Human inter-alpha-trypsin inhibitor heavy chain H3 gene. Genomic organization, promoter analysis, and gene linkage. Diarra-Mehrpour, M., Sarafan, N., Bourguignon, J., Bonnet, F., Bost, F., Martin, J.P. J. Biol. Chem. (1998) [Pubmed]
  4. An interplay of Sp1, GKLF and CREB-2 controls human Pre-alpha-Inhibitor gene (ITIH3) transcription. Ruminy, P., Rouet, P., Salier, J.P. Gene (2003) [Pubmed]
  5. Relationships between growth, morphology and wall stress in the stalk of Acetabularia acetabulum. von Dassow, M., Odell, G.M., Mandoli, D.F. Planta (2001) [Pubmed]
  6. Prolactin levels during long-term risperidone treatment in children and adolescents. Findling, R.L., Kusumakar, V., Daneman, D., Moshang, T., De Smedt, G., Binder, C. The Journal of clinical psychiatry. (2003) [Pubmed]
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