Disease relevance of ITIH3

• By using cDNA probes, a recombinant DNA phage has been isolated from a bacteriophage DNA library, which contains sequences flanking the 5' end of the ITIH3 gene and the 3' end of the ITIH1 gene [1].

High impact information on ITIH3

• SHAP potentiates the CD44-mediated leukocyte adhesion to the hyaluronan substratum [2].
• Leukocytes infiltrated to the synovium were strongly positive for HA, SHAP, and CD44 on their surfaces, suggesting a role for the adhesion-enhancing effect of SHAP in pathogenesis [2].
• We therefore examined the effect of SHAP on the CD44-HA interaction-mediated lymphocyte adhesion [2].
• We determined that the human ITIH1, ITIH3, and ITIH4 genes are closely linked within a 45-kilobase pair [3].
• ITIH3 shares highly conserved exon size and intron-exon borders with other ITI heavy chain genes [3].

Biological context of ITIH3

• The transient transfection study in various cell lines indicates that the activity of the ITIH3 promoter is not liver-specific [3].
• In order to understand the expression of this protein that is regulated in health and disease, we have analyzed the 5' flanking region of ITIH3, specifically focussing on its proximal promoter [4].
• The inter-alpha-trypsin inhibitor H1 (ITIH1) and inter-alpha-trypsin inhibitor H3 (ITIH3) genes have both previously been mapped to chromosomes 3 and 14 in the human and mouse, respectively [1].
• Restriction endonuclease mapping, PCR analysis and DNA sequence determination of the recombinant phage and comparison to genomic DNA revealed that the genes are in tandem, 2721 base pairs apart, with the ITIH1 gene to the 5' side of the ITIH3 gene [1].

Anatomical context of ITIH3

• A supplementary model, relating cell wall curvature and growth rate in the cut-interwhorl, characterizes how the stalk's final dimensions and nearly cylindrical shap may arise [5].

Associations of ITIH3 with chemical compounds

• BACKGROUND: This analysis was designed to investigate prolactin levels in children and adolescents on long-term risperidone treatment and explore any relationship with side effects hypothetically attributable to prolactin (SHAP) [6].

References