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Gene Review

JARID2  -  jumonji, AT rich interactive domain 2

Homo sapiens

Synonyms: JMJ, Jumonji/ARID domain-containing protein 2, Protein Jumonji
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Disease relevance of JARID2


High impact information on JARID2


Biological context of JARID2


Other interactions of JARID2

  • DTNBP1 is immediately adjacent to JARID2, a member of the ARID (AT-rich interaction domain) family of transcription modulators [4].


  1. Characterization of the human jumonji gene. Bergé-Lefranc, J.L., Jay, P., Massacrier, A., Cau, P., Mattei, M.G., Bauer, S., Marsollier, C., Berta, P., Fontes, M. Hum. Mol. Genet. (1996) [Pubmed]
  2. Evaluation of the jumonji gene and risk for spina bifida and congenital heart defects. Volcik, K.A., Zhu, H., Finnell, R.H., Shaw, G.M., Canfield, M., Lammer, E.J. Am. J. Med. Genet. A (2004) [Pubmed]
  3. Jumonji represses atrial natriuretic factor gene expression by inhibiting transcriptional activities of cardiac transcription factors. Kim, T.G., Chen, J., Sadoshima, J., Lee, Y. Mol. Cell. Biol. (2004) [Pubmed]
  4. Positive association of schizophrenia to JARID2 gene. Pedrosa, E., Ye, K., Nolan, K.A., Morrell, L., Okun, J.M., Persky, A.D., Saito, T., Lachman, H.M. Am. J. Med. Genet. B Neuropsychiatr. Genet. (2007) [Pubmed]
  5. JUMONJI, a critical factor for cardiac development, functions as a transcriptional repressor. Kim, T.G., Kraus, J.C., Chen, J., Lee, Y. J. Biol. Chem. (2003) [Pubmed]
  6. Jumonji is a nuclear protein that participates in the negative regulation of cell growth. Toyoda, M., Kojima, M., Takeuchi, T. Biochem. Biophys. Res. Commun. (2000) [Pubmed]
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