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Gene Review

ITGB1  -  integrin, beta 1 (fibronectin receptor,...

Gallus gallus

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High impact information on ITGB1

  • Here we have investigated the interaction of the purified CSAT antigen with these cytoskeletal components, and we demonstrate an interaction specifically between the CSAT antigen and talin [1].
  • Both laminin and fibronectin formed complexes with the CSAT antigen [2].
  • The CSAT monoclonal antibody, directed against this complex, inhibited adhesion of cardiac and tendon fibroblasts and skeletal myoblasts to both laminin and fibronectin, thus implicating the CSAT antigen in adhesion to these extracellular molecules [2].
  • We show that, in vitro, the JG22 antigen expressed by RGCs appears to function as a laminin receptor, by demonstrating that JG22 antibody blocks neurite outgrowth on a substrate of laminin [3].
  • The established cells retrieved at the end of the primary culture or the 20th subpassage were positive for chicken germ cell-specific periodic acid-Schiff (PAS), EMA1, 2C9, SSEA1, SSEA3, SSEA4, ITGA6, and ITGB1; and lectin-STA markers (evaluated after 11th subpassage) [4].

Other interactions of ITGB1


Analytical, diagnostic and therapeutic context of ITGB1

  • SDS PAGE showed that all three glycoproteins comprising the CSAT antigen were present in the antigen-ligand complexes [2].


  1. Interaction of plasma membrane fibronectin receptor with talin--a transmembrane linkage. Horwitz, A., Duggan, K., Buck, C., Beckerle, M.C., Burridge, K. Nature (1986) [Pubmed]
  2. The cell substrate attachment (CSAT) antigen has properties of a receptor for laminin and fibronectin. Horwitz, A., Duggan, K., Greggs, R., Decker, C., Buck, C. J. Cell Biol. (1985) [Pubmed]
  3. The role of laminin and the laminin/fibronectin receptor complex in the outgrowth of retinal ganglion cell axons. Cohen, J., Burne, J.F., McKinlay, C., Winter, J. Dev. Biol. (1987) [Pubmed]
  4. Identification, culture, and characterization of germline stem cell-like cells in chicken testes. Jung, J.G., Lee, Y.M., Park, T.S., Park, S.H., Lim, J.M., Han, J.Y. Biol. Reprod. (2007) [Pubmed]
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