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Gene Review

ITGB1  -  integrin, beta 1 (fibronectin receptor,...

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High impact information on ITGB1

  • Here we report the identification of TASC, a monoclonal antibody to a novel epitope on the integrin beta 1 subunit, which inhibits cell adhesion to vitronectin but promotes adhesion to laminin and collagen types I and IV [1].
  • Integrin-linked kinase (ILK) is a multidomain protein that interacts with the cytoplasmic tail of integrin beta subunits and is thought to participate in integrin-mediated signal transduction [2].
  • Antibody directed against integrin beta1 inhibited FBS-, Fn-, and Lm-mediated invasion but did not abrogate RGD-peptide-stimulated invasion [3].
  • The inclusion of an anticell adhesion receptor subunit sera (Lenny IV, against the integrin beta 1-subunit) in the culture medium for the first 2 days resulted in an irreversible loss of progestin secretion by the cultured granulosa cells, but the inclusion of a bacterial collagenase (form III) had no effect [4].
  • Focal adhesion complexes (FACs) containing integrin beta 1, talin, vinculin, talin, alpha-actinin, and paxillin formed within 15 min when round cells bound magnetic microbeads coated with integrin ligands, such as fibronectin or RGD-containing peptide, but not when coated with acetylated-low density lipoprotein [5].

Associations of ITGB1 with chemical compounds


Analytical, diagnostic and therapeutic context of ITGB1


  1. Cell-surface regulation of beta 1-integrin activity on developing retinal neurons. Neugebauer, K.M., Reichardt, L.F. Nature (1991) [Pubmed]
  2. ILK is required for the assembly of matrix-forming adhesions and capillary morphogenesis in endothelial cells. Vouret-Craviari, V., Boulter, E., Grall, D., Matthews, C., Van Obberghen-Schilling, E. J. Cell. Sci. (2004) [Pubmed]
  3. Streptococcus pyogenes serotype M1 encodes multiple pathways for entry into human epithelial cells. Cue, D., Dombek, P.E., Lam, H., Cleary, P.P. Infect. Immun. (1998) [Pubmed]
  4. A cell adhesion receptor antiserum abolishes, whereas laminin and fibronectin glycoprotein components of extracellular matrix promote, luteinization of cultured rat granulosa cells. Aten, R.F., Kolodecik, T.R., Behrman, H.R. Endocrinology (1995) [Pubmed]
  5. Rapid induction and isolation of focal adhesion complexes. Plopper, G., Ingber, D.E. Biochem. Biophys. Res. Commun. (1993) [Pubmed]
  6. The effects of estrogen and progesterone on prostaglandins and integrin beta 3 (beta3) subunit expression in primary cultures of bovine endometrial cells. Kimmins, S., Lim, H.C., Parent, J., Fortier, M.A., MacLaren, L.A. Domest. Anim. Endocrinol. (2003) [Pubmed]
  7. Spatiotemporal segregation of endothelial cell integrin and nonintegrin extracellular matrix-binding proteins during adhesion events. Basson, C.T., Knowles, W.J., Bell, L., Albelda, S.M., Castronovo, V., Liotta, L.A., Madri, J.A. J. Cell Biol. (1990) [Pubmed]
  8. A novel function of N-cadherin and Connexin43: marked enhancement of alkaline phosphatase activity in rat calvarial osteoblast exposed to sulfated hyaluronan. Nagahata, M., Tsuchiya, T., Ishiguro, T., Matsuda, N., Nakatsuchi, Y., Teramoto, A., Hachimori, A., Abe, K. Biochem. Biophys. Res. Commun. (2004) [Pubmed]
  9. Development of surface-based assays for transmembrane proteins: selective immobilization of functional CCR5, a G protein-coupled receptor. Silin, V.I., Karlik, E.A., Ridge, K.D., Vanderah, D.J. Anal. Biochem. (2006) [Pubmed]
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