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Gene Review

FN1  -  fibronectin 1

Gallus gallus

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Disease relevance of FN1

  • We detected little change in fibronectin splicing, other than a slight increase in representation of EIIIB+ species in fibroblasts after transformation by Rous sarcoma virus [1].
  • To check the specificity of this aggregation, a fusion protein (FGTNr) consisting of glutathione S-transferase linked to the six immunoglobulin domains and the first fibronectin type III repeat of Nr-CAM was expressed in Escherichia coli [2].
  • Embryonic chick ciliary ganglion (CG) neurons regenerate neurites rapidly on surfaces coated with laminin (LN), fibronectin (FN), conditioned media (CM) from several non-neuronal cell types that secrete LN, and on intact extracellular matrices [3].
  • Changes in the fibronectin-specific integrin expression pattern modify the migratory behavior of sarcoma S180 cells in vitro and in the embryonic environment [4].
  • If soluble collagen, laminin, or fibronectin is added to the medium, however, blebs are withdrawn and by 2-6 h the basal surface is flat [5].

Psychiatry related information on FN1

  • These results indicate that external macromolecules other than fibronectin are synthesized by cultured fibroblasts and can affect cell social behavior or culture morphology [6].
  • A fragment of the L1 molecule derived from the external fibronectin domains FN1-5 produced amnesia only when injected at the 5.5-hr timepoint, whereas a fragment of the immunoglubin-like domains Ig I-VI produced amnesia only when injected 30 min prior to training [7].

High impact information on FN1

  • Movement of beads coated with fibronectin or an anti-integrin antibody was restrained with an optical trap on fibroblasts to mimic extracellular attachment sites of different resistance [8].
  • Cells precisely sense the restraining force on fibronectin beads and respond by a localized, proportional strengthening of the cytoskeleton linkages, allowing stronger force to be exerted on the integrins [8].
  • There is 45% homology between the beta subunit sequence and band III of integrin, a chick fibronectin and laminin receptor [9].
  • Fibronectin-degrading proteases from the membranes of transformed cells [10].
  • The local degradation of fibronectin substrata by Rous sarcoma virus-transformed chick embryonic fibroblasts requires cell-contact-related metalloendoprotease and serine-protease activities [10].

Chemical compound and disease context of FN1


Biological context of FN1


Anatomical context of FN1

  • Fibronectin, therefore, is a potential ligand for general radial neuronal migration in the chick optic tectum [16].
  • The exon encoding the fibronectin type III-9 repeat is constitutively included in the mRNA from chick limb mesenchyme and cartilage [17].
  • Primary calvarial cells cultured on purified tenascin-W become rounded, and fewer of these cells spread on fibronectin when tenascin-W is added to the medium when compared with calvarial cells cultured on fibronectin alone [19].
  • Here, we report that addition of IGFII promoted the EndoMT process in the presence of very low amounts of chicken serum to arrested primary embryonic aortic chicken endothelial cells attached to fibronectin (FN), gelatin, or native type I collagen [20].
  • When mononuclear cells (MNCs) isolated from human cord blood were cultured on fibronectin-coated plates for 7 days, myoseverin decreased the number of adherent cells in a dose-dependent manner with IC(50) of approximately 9 microM [21].

Associations of FN1 with chemical compounds


Physical interactions of FN1


Enzymatic interactions of FN1


Regulatory relationships of FN1

  • TGF alpha stimulates fibronectin production in hen granulosa cells and is an important survival factor during follicular maturation [29].
  • Pretreatment of collagen gels with the proteoglycan monomer from bovine nasal cartilage had no effect of the adhesion of crest cells, but the proteoglycan almost completely inhibited adhesion to adsorbed fibronectin, but only when absorbed collagen was also present [31].

Other interactions of FN1


Analytical, diagnostic and therapeutic context of FN1


  1. Alternative splicing of chicken fibronectin in embryos and in normal and transformed cells. Norton, P.A., Hynes, R.O. Mol. Cell. Biol. (1987) [Pubmed]
  2. Homophilic and heterophilic binding activities of Nr-CAM, a nervous system cell adhesion molecule. Mauro, V.P., Krushel, L.A., Cunningham, B.A., Edelman, G.M. J. Cell Biol. (1992) [Pubmed]
  3. Distinct molecular interactions mediate neuronal process outgrowth on non-neuronal cell surfaces and extracellular matrices. Tomaselli, K.J., Reichardt, L.F., Bixby, J.L. J. Cell Biol. (1986) [Pubmed]
  4. Changes in the fibronectin-specific integrin expression pattern modify the migratory behavior of sarcoma S180 cells in vitro and in the embryonic environment. Beauvais, A., Erickson, C.A., Goins, T., Craig, S.E., Humphries, M.J., Thiery, J.P., Dufour, S. J. Cell Biol. (1995) [Pubmed]
  5. Response of basal epithelial cell surface and Cytoskeleton to solubilized extracellular matrix molecules. Sugrue, S.P., Hay, E.D. J. Cell Biol. (1981) [Pubmed]
  6. Characterization of factor(s) in culture supernatants affecting cell social behavior. Weston, J.A., Yamada, K.M., Hendricks, K.L. J. Cell. Physiol. (1979) [Pubmed]
  7. A role for a chicken homolog of the neural cell adhesion molecule L1 in consolidation of memory for a passive avoidance task in the chick. Scholey, A.B., Mileusnic, R., Schachner, M., Rose, S.P. Learn. Mem. (1995) [Pubmed]
  8. Extracellular matrix rigidity causes strengthening of integrin-cytoskeleton linkages. Choquet, D., Felsenfeld, D.P., Sheetz, M.P. Cell (1997) [Pubmed]
  9. Cloning of the beta subunit of the leukocyte adhesion proteins: homology to an extracellular matrix receptor defines a novel supergene family. Kishimoto, T.K., O'Connor, K., Lee, A., Roberts, T.M., Springer, T.A. Cell (1987) [Pubmed]
  10. Fibronectin-degrading proteases from the membranes of transformed cells. Chen, J.M., Chen, W.T. Cell (1987) [Pubmed]
  11. Glycoprotein Ic-IIa functions as an activation-independent fibronectin receptor on human platelets. Piotrowicz, R.S., Orchekowski, R.P., Nugent, D.J., Yamada, K.Y., Kunicki, T.J. J. Cell Biol. (1988) [Pubmed]
  12. Fibronectin from chicken embryo fibroblasts contains covalently bound phosphate. Teng, M.H., Rifkin, D.B. J. Cell Biol. (1979) [Pubmed]
  13. Dynamic microtubule ends are required for growth cone turning to avoid an inhibitory guidance cue. Challacombe, J.F., Snow, D.M., Letourneau, P.C. J. Neurosci. (1997) [Pubmed]
  14. The splicing pattern of fibronectin mRNA changes during chondrogenesis resulting in an unusual form of the mRNA in cartilage. Bennett, V.D., Pallante, K.M., Adams, S.L. J. Biol. Chem. (1991) [Pubmed]
  15. Comparison of the relative importance of tyrosine-specific vinculin phosphorylation and the loss of surface-associated fibronectin in the morphology of cells transformed by Rous sarcoma virus. Kellie, S., Patel, B., Mitchell, A., Critchley, D.R., Wigglesworth, N.M., Wyke, J.A. J. Cell. Sci. (1986) [Pubmed]
  16. Radial glia produce and align the ligand fibronectin during neuronal migration in the developing chick brain. Stettler, E.M., Galileo, D.S. J. Comp. Neurol. (2004) [Pubmed]
  17. The exon encoding the fibronectin type III-9 repeat is constitutively included in the mRNA from chick limb mesenchyme and cartilage. Gehris, A.L., Brandli, D.W., Lewis, S.D., Bennett, V.D. Biochim. Biophys. Acta (1996) [Pubmed]
  18. Isolation of genomic DNA clones spanning the entire fibronectin gene. Hirano, H., Yamada, Y., Sullivan, M., de Crombrugghe, B., Pastan, I., Yamada, K.M. Proc. Natl. Acad. Sci. U.S.A. (1983) [Pubmed]
  19. Avian tenascin-W: expression in smooth muscle and bone, and effects on calvarial cell spreading and adhesion in vitro. Meloty-Kapella, C.V., Degen, M., Chiquet-Ehrismann, R., Tucker, R.P. Dev. Dyn. (2006) [Pubmed]
  20. Potential role for insulin-like growth factor II and vitronectin in the endothelial-mesenchymal transition process. Arciniegas, E., Neves, Y.C., Carrillo, L.M. Differentiation (2006) [Pubmed]
  21. Myoseverin is a potential angiogenesis inhibitor by inhibiting endothelial cell function and endothelial progenitor cell differentiation. Park, H.E., Baek, S.H., Min, J., Chang, Y.T., Kang, D.K., Chang, S.I., Joe, Y.A. DNA Cell Biol. (2006) [Pubmed]
  22. Enhanced cellular fibronectin accumulation in chondrocytes treated with vitamin A. Hassell, J.R., Pennypacker, J.P., Kleinman, H.K., Pratt, R.M., Yamada, K.M. Cell (1979) [Pubmed]
  23. Fibronectin alters the phenotypic properties of cultured chick embryo chondroblasts. West, C.M., Lanza, R., Rosenbloom, J., Lowe, M., Holtzer, H., Avdalovic, N. Cell (1979) [Pubmed]
  24. Interaction of plasma membrane fibronectin receptor with talin--a transmembrane linkage. Horwitz, A., Duggan, K., Buck, C., Beckerle, M.C., Burridge, K. Nature (1986) [Pubmed]
  25. Identification of a heparin-binding hemagglutinin present in mycobacteria. Menozzi, F.D., Rouse, J.H., Alavi, M., Laude-Sharp, M., Muller, J., Bischoff, R., Brennan, M.J., Locht, C. J. Exp. Med. (1996) [Pubmed]
  26. Dynamic cytoskeleton-integrin associations induced by cell binding to immobilized fibronectin. Mueller, S.C., Kelly, T., Dai, M.Z., Dai, H.N., Chen, W.T. J. Cell Biol. (1989) [Pubmed]
  27. Chondroitin sulfate proteoglycan (PG-M-like proteoglycan) is involved in the binding of hyaluronic acid to cellular fibronectin. Yamagata, M., Yamada, K.M., Yoneda, M., Suzuki, S., Kimata, K. J. Biol. Chem. (1986) [Pubmed]
  28. The cell substrate attachment (CSAT) antigen has properties of a receptor for laminin and fibronectin. Horwitz, A., Duggan, K., Greggs, R., Decker, C., Buck, C. J. Cell Biol. (1985) [Pubmed]
  29. Follicular stage-dependent tumor necrosis factor alpha-induced hen granulosa cell integrin production and survival in the presence of transforming growth factor alpha in vitro. Soboloff, J., Sasaki, H., Tsang, B.K. Biol. Reprod. (2001) [Pubmed]
  30. v-Src-induced degradation of focal adhesion kinase during morphological transformation of chicken embryo fibroblasts. Fincham, V.J., Wyke, J.A., Frame, M.C. Oncogene (1995) [Pubmed]
  31. Adhesion to extracellular materials by neural crest cells at the stage of initial migration. Newgreen, D.F. Cell Tissue Res. (1982) [Pubmed]
  32. Identification of chicken embryo kinase 5, a developmentally regulated receptor-type tyrosine kinase of the Eph family. Pasquale, E.B. Cell Regul. (1991) [Pubmed]
  33. Neural cell recognition molecule F11: homology with fibronectin type III and immunoglobulin type C domains. Brümmendorf, T., Wolff, J.M., Frank, R., Rathjen, F.G. Neuron (1989) [Pubmed]
  34. Fluorescent gangliosides as probes for the retention and organization of fibronectin by ganglioside-deficient mouse cells. Spiegel, S., Yamada, K.M., Hom, B.E., Moss, J., Fishman, P.H. J. Cell Biol. (1985) [Pubmed]
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