The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Sdc  -  Syndecan

Drosophila melanogaster

Synonyms: CG10497, CT27296, Dmel\CG10497, Dsyn, Syd, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on Sdc

  • Sdc promotes the growth of presynaptic terminals, whereas Dlp regulates active zone form and function [1].
  • As in mammals, Drosophila syndecan is a heparan sulfate proteoglycan expressed at the cell surface that can be shed from cultured cells [2].
  • Based on the conserved transmembrane and cytoplasmic domains of the mammalian syndecans, a single syndecan-like gene was detected and localized in the Drosophila genome [2].
  • Thus, Sdc is a ligand that can act in trans to positively regulate signal transduction through LAR within neuronal growth cones [3].
  • Genetic interaction studies using Sdc and Lar LOF mutations demonstrate that Sdc contributes to LAR's function in motor axon guidance [3].

Biological context of Sdc


Anatomical context of Sdc


Associations of Sdc with chemical compounds


Other interactions of Sdc

  • Here, we report that the Drosophila homolog of Syndecan (reviewed in ), a heparan sulfate proteoglycan (HSPG), is required for proper Slit signaling [5].


  1. The HSPGs Syndecan and Dallylike bind the receptor phosphatase LAR and exert distinct effects on synaptic development. Johnson, K.G., Tenney, A.P., Ghose, A., Duckworth, A.M., Higashi, M.E., Parfitt, K., Marcu, O., Heslip, T.R., Marsh, J.L., Schwarz, T.L., Flanagan, J.G., Van Vactor, D. Neuron (2006) [Pubmed]
  2. Drosophila syndecan: conservation of a cell-surface heparan sulfate proteoglycan. Spring, J., Paine-Saunders, S.E., Hynes, R.O., Bernfield, M. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  3. The heparan sulfate proteoglycan syndecan is an in vivo ligand for the Drosophila LAR receptor tyrosine phosphatase. Fox, A.N., Zinn, K. Curr. Biol. (2005) [Pubmed]
  4. Syndecan-dependent binding of Drosophila hemocytes to laminin alpha3/5 chain LG4-5 modules: potential role in sessile hemocyte islets formation. Narita, R., Yamashita, H., Goto, A., Imai, H., Ichihara, S., Mori, H., Kitagawa, Y. FEBS Lett. (2004) [Pubmed]
  5. Heparan sulfate proteoglycan syndecan promotes axonal and myotube guidance by slit/robo signaling. Steigemann, P., Molitor, A., Fellert, S., Jäckle, H., Vorbrüggen, G. Curr. Biol. (2004) [Pubmed]
WikiGenes - Universities