High impact information on Sdc

• Sdc promotes the growth of presynaptic terminals, whereas Dlp regulates active zone form and function [1].
• As in mammals, Drosophila syndecan is a heparan sulfate proteoglycan expressed at the cell surface that can be shed from cultured cells [2].
• Based on the conserved transmembrane and cytoplasmic domains of the mammalian syndecans, a single syndecan-like gene was detected and localized in the Drosophila genome [2].
• Thus, Sdc is a ligand that can act in trans to positively regulate signal transduction through LAR within neuronal growth cones [3].
• Genetic interaction studies using Sdc and Lar LOF mutations demonstrate that Sdc contributes to LAR's function in motor axon guidance [3].

Biological context of Sdc

• RNA interference of syndecan in Kc167 cells impaired the binding, but that of dally or dally-like did not [4].

Anatomical context of Sdc

• Heparan sulfate proteoglycan syndecan promotes axonal and myotube guidance by slit/robo signaling [5].
• Syndecan-dependent binding of Drosophila hemocytes to laminin alpha3/5 chain LG4-5 modules: potential role in sessile hemocyte islets formation [4].

Associations of Sdc with chemical compounds

• The heparan sulfate proteoglycan syndecan is an in vivo ligand for the Drosophila LAR receptor tyrosine phosphatase [3].

Other interactions of Sdc

• Here, we report that the Drosophila homolog of Syndecan (reviewed in ), a heparan sulfate proteoglycan (HSPG), is required for proper Slit signaling [5].

References