High impact information on gol

• (iii) Loss of the Ubx+ gene early in embryogenesis, but not later, leads to the inappropriate activity of the Scr+ gene in the meso- and metathorax [1].
• By transplanting meso - and metathoracic myoblasts into the abdomen, we demonstrate that the fusion abilities of myoblasts are independent of their segmental identities [2].
• The results suggest that the wild-type function of Serrate is required for the control of position-specific cell proliferation during development of meso- and metathoracic dorsal discs, which in turn exerts a direct effect on morphogenesis [3].
• As part of a cloning strategy to identify genes involved in early mouse liver development we have isolated Praja1, a gene with similar sequences to the Drosophila melanogaster gene goliath (gl) which is involved in the fate of mesodermal cells ultimately forming gut musculatures, fat body, and the heart [4].
• In Drosophila, the RING finger protein d-Goliath was originally identified as a transcription factor involved in the embryo mesoderm formation [Bouchard, M.L., Cote, S., 1993. The Drosophila melanogaster developmental gene g1 encodes a variant zinc-finger-motif protein. Gene 125, 205-209] [5].

Biological context of gol

• These features indicate a functional role for g1, which remains to be elucidated, in regulating gene expression during mesoderm formation [6].
• The Drosophila melanogaster developmental gene g1 encodes a variant zinc-finger-motif protein [6].
• In mouse, the m-Goliath mRNA level was shown to be increased in growth factor withdrawal-induced apoptosis of myeloid cells [Baker, S.J., Reddy, E.P., 2000. Cloning of murine G1RP, a novel gene related to Drosophila melanogaster g1. Gene 248, 33-40] [5].
• In subsequent cell divisions descendants of the first three micromere duets form an outer layer of epidermal and neural progenitors surrounding the meso/endoderm progenitors, which are themselves descended from the macromere duet 4A, B and the micromere duet 4a, b [7].

Anatomical context of gol

• Neurons and processes were also labeled in the meso- and metathoracic ganglia [8].

References