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Gene Review

gol  -  goliath

Drosophila melanogaster

Synonyms: CG2679, Dmel\CG2679, GL, Gol, Protein g1, ...
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High impact information on gol

  • (iii) Loss of the Ubx+ gene early in embryogenesis, but not later, leads to the inappropriate activity of the Scr+ gene in the meso- and metathorax [1].
  • By transplanting meso - and metathoracic myoblasts into the abdomen, we demonstrate that the fusion abilities of myoblasts are independent of their segmental identities [2].
  • The results suggest that the wild-type function of Serrate is required for the control of position-specific cell proliferation during development of meso- and metathoracic dorsal discs, which in turn exerts a direct effect on morphogenesis [3].
  • As part of a cloning strategy to identify genes involved in early mouse liver development we have isolated Praja1, a gene with similar sequences to the Drosophila melanogaster gene goliath (gl) which is involved in the fate of mesodermal cells ultimately forming gut musculatures, fat body, and the heart [4].
  • In Drosophila, the RING finger protein d-Goliath was originally identified as a transcription factor involved in the embryo mesoderm formation [Bouchard, M.L., Cote, S., 1993. The Drosophila melanogaster developmental gene g1 encodes a variant zinc-finger-motif protein. Gene 125, 205-209] [5].

Biological context of gol


Anatomical context of gol

  • Neurons and processes were also labeled in the meso- and metathoracic ganglia [8].


  1. Genes controlling segmental specification in the Drosophila thorax. Struhl, G. Proc. Natl. Acad. Sci. U.S.A. (1982) [Pubmed]
  2. Homeotic genes and the regulation of myoblast migration, fusion, and fibre-specific gene expression during adult myogenesis in Drosophila. Roy, S., VijayRaghavan, K. Development (1997) [Pubmed]
  3. The Serrate locus of Drosophila and its role in morphogenesis of the wing imaginal discs: control of cell proliferation. Speicher, S.A., Thomas, U., Hinz, U., Knust, E. Development (1994) [Pubmed]
  4. Praja1, a novel gene encoding a RING-H2 motif in mouse development. Mishra, L., Tully, R.E., Monga, S.P., Yu, P., Cai, T., Makalowski, W., Mezey, E., Pavan, W.J., Mishra, B. Oncogene (1997) [Pubmed]
  5. h-Goliath, paralog of GRAIL, is a new E3 ligase protein, expressed in human leukocytes. Guais, A., Siegrist, S., Solhonne, B., Jouault, H., Guellaën, G., Bulle, F. Gene (2006) [Pubmed]
  6. The Drosophila melanogaster developmental gene g1 encodes a variant zinc-finger-motif protein. Bouchard, M.L., Côté, S. Gene (1993) [Pubmed]
  7. Embryonic development in the primitive bilaterian Neochildia fusca: normal morphogenesis and isolation of POU genes Brn-1 and Brn-3. Ramachandra, N.B., Gates, R.D., Ladurner, P., Jacobs, D.K., Hartenstein, V. Dev. Genes Evol. (2002) [Pubmed]
  8. Antibodies against the PER protein of Drosophila label neurons in the optic lobe, central brain, and thoracic ganglia of the crickets Teleogryllus commodus and Teleogryllus oceanicus. Lupien, M., Marshall, S., Leser, W., Pollack, G.S., Honegger, H.W. Cell Tissue Res. (2003) [Pubmed]
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