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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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KIFC3  -  kinesin family member C3

Homo sapiens

Synonyms: Kinesin-like protein KIFC3
 
 
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Disease relevance of KIFC3

 

High impact information on KIFC3

  • Absence of cytoplasmic dynein on these annexin XIIIb-associated vesicles and distinct distribution of the two motors on the EM level verified the existence of KIFC3-driven transport in epithelial cells [2].
  • KIFC3, a microtubule minus end-directed motor for the apical transport of annexin XIIIb-associated Triton-insoluble membranes [2].
  • In polarized epithelial cells, KIFC3 is localized on membrane organelles immediately beneath the apical plasma membrane of renal tubular epithelial cells in vivo and polarized MDCK II cells in vitro [2].
  • Two candidate genes KIFC3 and CNGB1 mapping to this critical interval have been screened for mutations [3].
  • The chromosomal localization and expression pattern of KIFC3 suggest that it may be an excellent candidate for families linked to BBS2 [1].
 

Biological context of KIFC3

 

Anatomical context of KIFC3

  • KIFC3 is a minus end-directed microtubule motor protein, therefore it accumulates in regions where minus ends of microtubules assemble [2].
  • Flotation assay, coupled with detergent extraction, demonstrated that KIFC3 is associated with Triton X-100-insoluble membrane organelles, and that it overlaps with apically transported TGN-derived vesicles [2].
 

Regulatory relationships of KIFC3

  • Characterization of a novel C-kinesin (KIFC3) abundantly expressed in vertebrate retina and RPE [4].
 

Other interactions of KIFC3

  • We describe here the kinesin PCR screen of human retina and RPE and examine the tissue and subcellular distribution of KIFC3 in both fish and human retina using an antibody raised against a peptide conserved between FKIF2 and HsKIFC3 [4].
 

Analytical, diagnostic and therapeutic context of KIFC3

  • This was confirmed by immunoprecipitation and by GST pulldown experiments showing the specific colocalization of KIFC3 and annexin XIIIb, a previously characterized membrane protein for apically transported vesicles (Lafont, F., S. Lecat, P. Verkade, and K. Simons. 1998. J. Cell Biol. 142:1413-1427) [2].

References

 
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