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Gene Review

KIR2DS1  -  killer cell immunoglobulin-like receptor,...

Homo sapiens

Synonyms: CD158 antigen-like family member H, CD158H, CD158a, EB6ActI, EB6ActII, ...
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Disease relevance of KIR2DS1

  • Infection of cells with Epstein-Barr virus leads to expression of a detectable ligand for the activating receptor KIR2DS1 [1].
  • An increase in the frequency of the activating KIR2DS1 gene was detected in the PsA patients, compared with psoriasis patients negative for PsA and an unaffected American Caucasian control group [2].
  • Activating killer cell immunoglobulin-like receptor gene KIR2DS1 is associated with psoriatic arthritis [2].
  • Furthermore, an increased frequency of activating KIR2DS1 in the absence of the putative HLA-C(Lys80) ligands was found in melanoma patients (16.0% vs 9.2%) [3].

High impact information on KIR2DS1

  • KIR2DS1 and its inhibitory homologue, KIR2DL1, share sensitivity to peptide sequence alterations at positions 7 and 8 [1].
  • We discuss how our results for KIR2DS1 and parallel studies on KIR2DS2 relate to the association between activating KIR genes and susceptibility to autoimmune disorders [1].
  • Importantly, KIR2DS1 is not always sufficient to trigger NK effector responses when faced with cognate ligand, consistent with fine control during NK cell activation [1].
  • In this case, KIR2DS1 interacts with up-regulated peptide-MHC class I complexes on Epstein-Barr virus-infected cells in a transporter associated with antigen processing (TAP)-dependent manner [1].
  • Again, this effect was dependent on FasL secretion and it was blocked by specific mAb to KIR2DS2 or KIR2DS1 [4].

Biological context of KIR2DS1


Anatomical context of KIR2DS1


Associations of KIR2DS1 with chemical compounds

  • Thus, substitution in p50.1 of lysine 70 by threonine (typical of the inhibitory p58.1 molecule) resulted in a dramatic increase in binding affinity, comparable to that of the p58.1 molecule [6].

Other interactions of KIR2DS1

  • When individual genes were considered, a decrease in KIR2DS5 among patients vs controls (OR = 0.2, pcor = 0.0005) and a decrease in KIR2DS3 restricted to KIR2DS1-positive individuals (OR = 0.2, pcor = 0.005) were evident [7].

Analytical, diagnostic and therapeutic context of KIR2DS1


  1. Recognition of peptide-MHC class I complexes by activating killer immunoglobulin-like receptors. Stewart, C.A., Laugier-Anfossi, F., Vély, F., Saulquin, X., Riedmuller, J., Tisserant, A., Gauthier, L., Romagné, F., Ferracci, G., Arosa, F.A., Moretta, A., Sun, P.D., Ugolini, S., Vivier, E. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  2. Activating killer cell immunoglobulin-like receptor gene KIR2DS1 is associated with psoriatic arthritis. Williams, F., Meenagh, A., Sleator, C., Cook, D., Fernandez-Vina, M., Bowcock, A.M., Middleton, D. Hum. Immunol. (2005) [Pubmed]
  3. Genetic polymorphism of NK receptors and their ligands in melanoma patients: prevalence of inhibitory over activating signals. Naumova, E., Mihaylova, A., Stoitchkov, K., Ivanova, M., Quin, L., Toneva, M. Cancer Immunol. Immunother. (2005) [Pubmed]
  4. Regulation of gammadelta T cell survival by soluble HLA-I: involvement of CD8 and activating killer Ig-like receptors. Poggi, A., Contini, P., Catellani, S., Setti, M., Murdaca, G., Zocchi, M.R. Eur. J. Immunol. (2005) [Pubmed]
  5. Gene for the activating natural killer cell receptor, KIR2DS1, is associated with susceptibility to psoriasis vulgaris. Łuszczek, W., Mańczak, M., Cisło, M., Nockowski, P., Wiśniewski, A., Jasek, M., Kuśnierczyk, P. Hum. Immunol. (2004) [Pubmed]
  6. Role of amino acid position 70 in the binding affinity of p50.1 and p58.1 receptors for HLA-Cw4 molecules. Biassoni, R., Pessino, A., Malaspina, A., Cantoni, C., Bottino, C., Sivori, S., Moretta, L., Moretta, A. Eur. J. Immunol. (1997) [Pubmed]
  7. A role for KIR gene variants other than KIR2DS1 in conferring susceptibility to psoriasis. Płoski, R., Luszczek, W., Kuśnierczyk, P., Nockowski, P., Cisło, M., Krajewski, P., Malejczyk, J. Hum. Immunol. (2006) [Pubmed]
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