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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Gene Review

KIR2DS2  -  killer cell immunoglobulin-like receptor,...

Homo sapiens

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Disease relevance of KIR2DS2


High impact information on KIR2DS2

  • We also report the 2.3-A structure of KIR2DS2, which reveals subtle displacements of two residues (Tyr45 and Gln71) involved in the interaction of KIR2DL2 with HLA-Cw3 [3].
  • Crystal structure of the human natural killer cell activating receptor KIR2DS2 (CD158j) [3].
  • CD4(+)CD28(null) T cell clones isolated from RA patients with vasculitis were found to express killer cell immunoglobulin-like receptors (KIRs) with the stimulatory KIR2DS2 often present in the absence of opposing inhibitory receptors with related specificities [4].
  • Specifically, KIR2DS2 in conjunction with the appropriate HLA-C ligand may have a role in vascular damage by regulating CD4(+)CD28(null) T cells [4].
  • Moreover, this effect is seen only when the donor additionally carries the activating KIR gene KIR2DS2 (P =.045) [5].

Biological context of KIR2DS2


Anatomical context of KIR2DS2


Associations of KIR2DS2 with chemical compounds

  • Substitution of tyrosine 45 with the phenylalanine conserved in other KIR was sufficient to permit specific binding of KIR2DS2 to HLA-C [13].
  • We also found KIR2DS2 with its presumed C1 group ligand less prevalent in TB patients than in the control group, but this result lost significance after correction [14].

Other interactions of KIR2DS2


Analytical, diagnostic and therapeutic context of KIR2DS2

  • In contrast, the presence of KIR2DS2 (n = 13/25 donors) was associated with decreased probability of overall survival (0% vs 92%, P = .04) and disease-free survival (0% vs 92%, P = .046) [8].


  1. Selective activation of the c-Jun NH2-terminal protein kinase signaling pathway by stimulatory KIR in the absence of KARAP/DAP12 in CD4+ T cells. Snyder, M.R., Lucas, M., Vivier, E., Weyand, C.M., Goronzy, J.J. J. Exp. Med. (2003) [Pubmed]
  2. Characteristics of binding of Escherichia coli serotype O157:H7 strain CL-49 to purified intestinal mucin. Sajjan, S.U., Forstner, J.F. Infect. Immun. (1990) [Pubmed]
  3. Crystal structure of the human natural killer cell activating receptor KIR2DS2 (CD158j). Saulquin, X., Gastinel, L.N., Vivier, E. J. Exp. Med. (2003) [Pubmed]
  4. Major histocompatibility complex class I-recognizing receptors are disease risk genes in rheumatoid arthritis. Yen, J.H., Moore, B.E., Nakajima, T., Scholl, D., Schaid, D.J., Weyand, C.M., Goronzy, J.J. J. Exp. Med. (2001) [Pubmed]
  5. The impact of donor KIR and patient HLA-C genotypes on outcome following HLA-identical sibling hematopoietic stem cell transplantation for myeloid leukemia. Cook, M.A., Milligan, D.W., Fegan, C.D., Darbyshire, P.J., Mahendra, P., Craddock, C.F., Moss, P.A., Briggs, D.C. Blood (2004) [Pubmed]
  6. KIR haplotype content at the allele level in 77 Northern Irish families. Middleton, D., Meenagh, A., Gourraud, P.A. Immunogenetics (2007) [Pubmed]
  7. Formation of the killer Ig-like receptor repertoire on CD4+CD28null T cells. Snyder, M.R., Muegge, L.O., Offord, C., O'Fallon, W.M., Bajzer, Z., Weyand, C.M., Goronzy, J.J. J. Immunol. (2002) [Pubmed]
  8. Impact of activating killer immunoglobulin-like receptor genotype on outcome of unrelated donor-hematopoietic cell transplantation. Giebel, S., Nowak, I., Wojnar, J., Markiewicz, M., Dziaczkowska, J., Wylezol, I., Krawczyk-Kulis, M., Bloch, R., Kusnierczyk, P., Holowiecki, J. Transplant. Proc. (2006) [Pubmed]
  9. Rheumatoid arthritis. Goronzy, J.J., Weyand, C.M. Immunol. Rev. (2005) [Pubmed]
  10. Regulation of gammadelta T cell survival by soluble HLA-I: involvement of CD8 and activating killer Ig-like receptors. Poggi, A., Contini, P., Catellani, S., Setti, M., Murdaca, G., Zocchi, M.R. Eur. J. Immunol. (2005) [Pubmed]
  11. Biphasic response of NK cells expressing both activating and inhibitory killer Ig-like receptors. Warren, H.S., Campbell, A.J., Waldron, J.C., Lanier, L.L. Int. Immunol. (2001) [Pubmed]
  12. Adherence of vero cytotoxin-producing Escherichia coli serotype O157:H7 to isolated epithelial cells and brush border membranes in vitro: role of type 1 fimbriae (pili) as a bacterial adhesin expressed by strain CL-49. Durno, C., Soni, R., Sherman, P. Clinical and investigative medicine. Médecine clinique et experimentale. (1989) [Pubmed]
  13. Direct binding and functional transfer of NK cell inhibitory receptors reveal novel patterns of HLA-C allotype recognition. Winter, C.C., Gumperz, J.E., Parham, P., Long, E.O., Wagtmann, N. J. Immunol. (1998) [Pubmed]
  14. Study of KIR genes in tuberculosis patients. M??ndez, A., Granda, H., Meenagh, A., Contreras, S., Zavaleta, R., Mendoza, M.F., Izquierdo, L., Sarmiento, M.E., Acosta, A., Middleton, D. Tissue Antigens (2006) [Pubmed]
  15. Stimulatory killer Ig-like receptors modulate T cell activation through DAP12-dependent and DAP12-independent mechanisms. Snyder, M.R., Nakajima, T., Leibson, P.J., Weyand, C.M., Goronzy, J.J. J. Immunol. (2004) [Pubmed]
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