The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

dos  -  daughter of sevenless

Drosophila melanogaster

Synonyms: 141511_at, CG1044, DOS, Dmel\CG1044, Dos, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on dos

  • Mutations of dos were identified in a screen for dominant mutations which enhance the phenotype caused by overexpression of inactive CSW during photoreceptor development [1].
  • By screening for mutations that suppress signaling via a constitutively activated SEV protein, we have identified a novel gene, daughter of sevenless (dos) [2].
  • The presence of an amino-terminally located pleckstrin homology domain and many potential tyrosine phosphorylation sites suggests that DOS functions as an adaptor protein able to interact with multiple signaling molecules [2].
  • Mutant DOS proteins in which either Y801 or Y854 of DOS has been changed to phenylalanine are unable to function during signaling by SEV and other receptor tyrosine kinases [3].
  • The pleckstrin homology (PH) domain-containing protein Daughter of Sevenless (DOS) is an essential component of the Sevenless receptor tyrosine kinase (SEV) signaling cascade, which specifies R7 photoreceptor development in the Drosophila eye [3].

Biological context of dos


Anatomical context of dos


Physical interactions of dos

  • We show that these sites become phosphorylated in response to SEV activation and that phosphorylation of both sites is required to allow CSW to bind DOS [3].

Enzymatic interactions of dos


Other interactions of dos

  • These results indicate that a primary role for DOS during signaling by SEV and other receptor tyrosine kinases is to become phosphorylated at Y801 and Y854 and then recruit CSW [3].
  • The Gab/dos/Soc-1 proteins form a family of multi-adaptor/scaffolding proteins involved in receptor tyrosine kinase signaling [5].
  • The target sequences for Poils au dos activity were mapped to a 14 kb region around scute [9].


  1. Daughter of sevenless is a substrate of the phosphotyrosine phosphatase Corkscrew and functions during sevenless signaling. Herbst, R., Carroll, P.M., Allard, J.D., Schilling, J., Raabe, T., Simon, M.A. Cell (1996) [Pubmed]
  2. DOS, a novel pleckstrin homology domain-containing protein required for signal transduction between sevenless and Ras1 in Drosophila. Raabe, T., Riesgo-Escovar, J., Liu, X., Bausenwein, B.S., Deak, P., Maröy, P., Hafen, E. Cell (1996) [Pubmed]
  3. Recruitment of the protein tyrosine phosphatase CSW by DOS is an essential step during signaling by the sevenless receptor tyrosine kinase. Herbst, R., Zhang, X., Qin, J., Simon, M.A. EMBO J. (1999) [Pubmed]
  4. In vivo functional analysis of the daughter of sevenless protein in receptor tyrosine kinase signaling. Bausenwein, B.S., Schmidt, M., Mielke, B., Raabe, T. Mech. Dev. (2000) [Pubmed]
  5. Evolution of Gab family adaptor proteins. Abbeyquaye, T., Riesgo-Escovar, J., Raabe, T., Thackeray, J.R. Gene (2003) [Pubmed]
  6. The Caenorhabditis elegans EGL-15 signaling pathway implicates a DOS-like multisubstrate adaptor protein in fibroblast growth factor signal transduction. Schutzman, J.L., Borland, C.Z., Newman, J.C., Robinson, M.K., Kokel, M., Stern, M.J. Mol. Cell. Biol. (2001) [Pubmed]
  7. Alcohols inhibit a cloned potassium channel at a discrete saturable site. Insights into the molecular basis of general anesthesia. Covarrubias, M., Vyas, T.B., Escobar, L., Wei, A. J. Biol. Chem. (1995) [Pubmed]
  8. A mutation (dosach) in Drosophila which affects aster formation and nuclear migration during cleavage. Craig, S.S., Brink, N.G. Biol. Cell (1996) [Pubmed]
  9. A major bristle QTL from a selected population of Drosophila uncovers the zinc-finger transcription factor poils-au-dos, a repressor of achaete-scute. Gibert, J.M., Marcellini, S., David, J.R., Schlötterer, C., Simpson, P. Dev. Biol. (2005) [Pubmed]
WikiGenes - Universities