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Gene Review

csw  -  corkscrew

Drosophila melanogaster

Synonyms: 19-106, CG3954, CSW, Csw, Csw/Shp2, ...
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High impact information on csw


Biological context of csw

  • In contrast, the interaction between CSW and Daughter of Sevenless, a CSW substrate, is dependent on SH2 domain function [5].
  • We have investigated this possibility by identifying tyrosine residues 801 and 854 of DOS as the phosphorylated binding sites for the CSW SH2 domains [6].
  • Expression of the mutant csw transgenes increased RAS-MAP kinase activation, which was necessary but not sufficient for transducing their phenotypes [7].

Associations of csw with chemical compounds

  • DIM-7, a Drosophila homolog of vertebrate importin-7, has recently been shown to bind the SHP-2 tyrosine phosphatase homolog Corkscrew and to be important in the nuclear translocation of activated D-ERK [8].

Physical interactions of csw

  • Substrate-trapping forms of Corkscrew bind Sprouty in cultured Drosophila cells and the developing eye [9].

Enzymatic interactions of csw

  • These results indicate that a primary role for DOS during signaling by SEV and other receptor tyrosine kinases is to become phosphorylated at Y801 and Y854 and then recruit CSW [6].

Regulatory relationships of csw

  • We find that dominant-negative mutations in either the drk or csw genes ameliorate the developmental abnormalities induced by activated DSrc [10].

Other interactions of csw

  • Second, we found that tissue-specific expression of a gain-of-function csw construct rescues loss-of-function mutations in other positive signaling genes upstream of rolled (rl)/MAPK in the EGFR pathway [11].
  • We found that the injection of activated p21v-ras rescued the maternal-effect phenotypes of both tor and csw null mutations [4].
  • Downstream-of-FGFR is a fibroblast growth factor-specific scaffolding protein and recruits Corkscrew upon receptor activation [12].
  • We demonstrate, using a series of mutations in the signal transducers Corkscrew/SHP-2 and D-Raf, that quantitative variations in the magnitude of MAPK activity trigger both qualitatively and quantitatively distinct transcriptional responses [13].
  • One of these, corkscrew (csw), encodes an SH2 domain-containing PTPase that appears to be a homolog of mammalian PTP1D [14].


  1. Daughter of sevenless is a substrate of the phosphotyrosine phosphatase Corkscrew and functions during sevenless signaling. Herbst, R., Carroll, P.M., Allard, J.D., Schilling, J., Raabe, T., Simon, M.A. Cell (1996) [Pubmed]
  2. corkscrew encodes a putative protein tyrosine phosphatase that functions to transduce the terminal signal from the receptor tyrosine kinase torso. Perkins, L.A., Larsen, I., Perrimon, N. Cell (1992) [Pubmed]
  3. Drosophila terminal structure development is regulated by the compensatory activities of positive and negative phosphotyrosine signaling sites on the Torso RTK. Cleghon, V., Gayko, U., Copeland, T.D., Perkins, L.A., Perrimon, N., Morrison, D.K. Genes Dev. (1996) [Pubmed]
  4. Control of cell fate determination by p21ras/Ras1, an essential component of torso signaling in Drosophila. Lu, X., Chou, T.B., Williams, N.G., Roberts, T., Perrimon, N. Genes Dev. (1993) [Pubmed]
  5. Mutational analysis of the SRC homology 2 domain protein-tyrosine phosphatase Corkscrew. Allard, J.D., Herbst, R., Carroll, P.M., Simon, M.A. J. Biol. Chem. (1998) [Pubmed]
  6. Recruitment of the protein tyrosine phosphatase CSW by DOS is an essential step during signaling by the sevenless receptor tyrosine kinase. Herbst, R., Zhang, X., Qin, J., Simon, M.A. EMBO J. (1999) [Pubmed]
  7. Transgenic Drosophila models of Noonan syndrome causing PTPN11 gain-of-function mutations. Oishi, K., Gaengel, K., Krishnamoorthy, S., Kamiya, K., Kim, I.K., Ying, H., Weber, U., Perkins, L.A., Tartaglia, M., Mlodzik, M., Pick, L., Gelb, B.D. Hum. Mol. Genet. (2006) [Pubmed]
  8. Genetic interaction between integrins and moleskin, a gene encoding a Drosophila homolog of importin-7. Baker, S.E., Lorenzen, J.A., Miller, S.W., Bunch, T.A., Jannuzi, A.L., Ginsberg, M.H., Perkins, L.A., Brower, D.L. Genetics (2002) [Pubmed]
  9. Sprouty proteins are in vivo targets of Corkscrew/SHP-2 tyrosine phosphatases. Jarvis, L.A., Toering, S.J., Simon, M.A., Krasnow, M.A., Smith-Bolton, R.K. Development (2006) [Pubmed]
  10. Signaling by ectopically expressed Drosophila Src64 requires the protein-tyrosine phosphatase corkscrew and the adapter downstream of receptor kinases. Cooper, J.A., Simon, M.A., Kussick, S.J. Cell Growth Differ. (1996) [Pubmed]
  11. Analysis of corkscrew signaling in the Drosophila epidermal growth factor receptor pathway during myogenesis. Johnson Hamlet, M.R., Perkins, L.A. Genetics (2001) [Pubmed]
  12. Downstream-of-FGFR is a fibroblast growth factor-specific scaffolding protein and recruits Corkscrew upon receptor activation. Petit, V., Nussbaumer, U., Dossenbach, C., Affolter, M. Mol. Cell. Biol. (2004) [Pubmed]
  13. Quantitative variations in the level of MAPK activity control patterning of the embryonic termini in Drosophila. Ghiglione, C., Perrimon, N., Perkins, L.A. Dev. Biol. (1999) [Pubmed]
  14. Drosophila protein tyrosine phosphatases. Zinn, K. Semin. Cell Biol. (1993) [Pubmed]
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