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Gene Review

KPNA4  -  karyopherin alpha 4 (importin alpha 3)

Homo sapiens

Synonyms: IPOA3, Importin alpha Q1, Importin subunit alpha-3, Karyopherin subunit alpha-4, MGC12217, ...
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High impact information on KPNA4

  • We did find evidence of additive effects of SRP3 with the COLIA1 Sp1 polymorphism but not with haplotypes of 3' polymorphisms in the vitamin-D receptor gene [1].
  • A 3-bp insertion (f=0.38) in the presumed SOST promoter region (SRP3) was associated with decreased BMD in women at the femoral neck (FN) (P=.05) and lumbar spine (LS) (P=.01), with evidence of an allele-dose effect in the oldest age group (P=.006) [1].
  • Rch1 (importin alpha1) bound only weakly and Qip1 (importin alpha3) did not bind to the Ser385-phosphorylated NLS [2].
  • The Caenorhabditis elegans muscle specific serpin, SRP-3, neutralizes chymotrypsin-like serine peptidases [3].
  • Analysis of SRP-3 inhibitory activity indicated that SRP-3 was a potent inhibitor of the serine peptidases, chymotrypsin and cathepsin G [3].

Biological context of KPNA4


Physical interactions of KPNA4

  • Two-hybrid experiments revealed that Qip1 interacted with the NLS of SV40 T antigen similar to Rch1 and hSrp1 [5].


  1. Polymorphisms in the sclerosteosis/van Buchem disease gene (SOST) region are associated with bone-mineral density in elderly whites. Uitterlinden, A.G., Arp, P.P., Paeper, B.W., Charmley, P., Proll, S., Rivadeneira, F., Fang, Y., van Meurs, J.B., Britschgi, T.B., Latham, J.A., Schatzman, R.C., Pols, H.A., Brunkow, M.E. Am. J. Hum. Genet. (2004) [Pubmed]
  2. Nuclear import of Epstein-Barr virus nuclear antigen 1 mediated by NPI-1 (Importin alpha5) is up- and down-regulated by phosphorylation of the nuclear localization signal for which Lys379 and Arg380 are essential. Kitamura, R., Sekimoto, T., Ito, S., Harada, S., Yamagata, H., Masai, H., Yoneda, Y., Yanagi, K. J. Virol. (2006) [Pubmed]
  3. The Caenorhabditis elegans muscle specific serpin, SRP-3, neutralizes chymotrypsin-like serine peptidases. Pak, S.C., Tsu, C., Luke, C.J., Askew, Y.S., Silverman, G.A. Biochemistry (2006) [Pubmed]
  4. Assignment of KPNA4 and KPNB1 encoding karyopherin alpha 4 and beta 1 to human chromosome bands 11q22 and 17q21 respectively, by in situ hybridization. Ayala-Madrigal, M.L., Doerr, S., Ramírez-Dueñas, M.L., Hansmann, I. Cytogenet. Cell Genet. (2000) [Pubmed]
  5. Cloning of a cDNA encoding a novel importin-alpha homologue, Qip1: discrimination of Qip1 and Rch1 from hSrp1 by their ability to interact with DNA helicase Q1/RecQL. Seki, T., Tada, S., Katada, T., Enomoto, T. Biochem. Biophys. Res. Commun. (1997) [Pubmed]
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