The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
Gene Review

VAR  -  erythrocyte membrane protein 1, PfEMP1

Plasmodium falciparum 3D7

 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of VAR

 

High impact information on VAR

 

Anatomical context of VAR

 

Associations of VAR with chemical compounds

 

Other interactions of VAR

  • The mature-parasite-infected erythrocyte surface antigen (MESA, also known as PfEMP-2 and pp300) of Plasmodium falciparum is a phosphoprotein of approx. 250-300 kDa that is exported from the parasite to the erythrocyte membrane skeleton where it binds to protein 4 [10].
  • Here we express epitope-tagged versions of the 2TM proteins in transgenic NF54 parasites and present evidence that the Stevor and Pfmc-2TM families are exported to the erythrocyte membrane, thus supporting the hypothesis that host immune pressure drives antigenic diversity within the loop [11].

References

  1. 3D7-Derived Plasmodium falciparum Erythrocyte Membrane Protein 1 Is a Frequent Target of Naturally Acquired Antibodies Recognizing Protein Domains in a Particular Pattern Independent of Malaria Transmission Intensity. Joergensen, L., Vestergaard, L.S., Turner, L., Magistrado, P., Lusingu, J.P., Lemnge, M., Theander, T.G., Jensen, A.T. J. Immunol. (2007) [Pubmed]
  2. Prediction of solubility on recombinant expression of Plasmodium falciparum erythrocyte membrane protein 1 domains in Escherichia coli. Ahuja, S., Ahuja, S., Chen, Q., Wahlgren, M. Malar. J. (2006) [Pubmed]
  3. Epigenetic memory at malaria virulence genes. Chookajorn, T., Dzikowski, R., Frank, M., Li, F., Jiwani, A.Z., Hartl, D.L., Deitsch, K.W. Proc. Natl. Acad. Sci. U.S.A. (2007) [Pubmed]
  4. Skeleton-binding protein 1 functions at the parasitophorous vacuole membrane to traffic PfEMP1 to the Plasmodium falciparum-infected erythrocyte surface. Maier, A.G., Rug, M., O'neill, M.T., Beeson, J.G., Marti, M., Reeder, J., Cowman, A.F. Blood (2007) [Pubmed]
  5. Increased B cell survival and preferential activation of the memory compartment by a malaria polyclonal B cell activator. Donati, D., Mok, B., Chêne, A., Xu, H., Thangarajh, M., Glas, R., Chen, Q., Wahlgren, M., Bejarano, M.T. J. Immunol. (2006) [Pubmed]
  6. Physical Linkage to Drug Resistance Genes Results in Conservation of var Genes among West Pacific Plasmodium falciparum Isolates. Fowler, E.V., Chavchich, M., Chen, N., Peters, J.M., Kyle, D.E., Gatton, M.L., Cheng, Q. J. Infect. Dis. (2006) [Pubmed]
  7. Plasmodium falciparum merozoite surface protein 6 (MSP-6) derived peptides bind erythrocytes and partially inhibit parasite invasion. López, R., Valbuena, J., Rodríguez, L.E., Ocampo, M., Vera, R., Curtidor, H., Puentes, A., García, J., Ramirez, L.E., Patarroyo, M.E. Peptides (2006) [Pubmed]
  8. Sodium-dependent uptake of inorganic phosphate by the intracellular malaria parasite. Saliba, K.J., Martin, R.E., Br??er, A., Henry, R.I., McCarthy, C.S., Downie, M.J., Allen, R.J., Mullin, K.A., McFadden, G.I., Br??er, S., Kirk, K. Nature (2006) [Pubmed]
  9. Delivery of the malaria virulence protein PfEMP1 to the erythrocyte surface requires cholesterol-rich domains. Frankland, S., Adisa, A., Horrocks, P., Taraschi, T.F., Schneider, T., Elliott, S.R., Rogerson, S.J., Knuepfer, E., Cowman, A.F., Newbold, C.I., Tilley, L. Eukaryotic Cell (2006) [Pubmed]
  10. Repeat structures in a Plasmodium falciparum protein (MESA) that binds human erythrocyte protein 4.1. Coppel, R.L. Mol. Biochem. Parasitol. (1992) [Pubmed]
  11. Hypervariability within the Rifin, Stevor and Pfmc-2TM superfamilies in Plasmodium falciparum. Lavazec, C., Sanyal, S., Templeton, T.J. Nucleic Acids Res. (2006) [Pubmed]
 
WikiGenes - Universities