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Gene Review:

HSD17B1 - hydroxysteroid (17-beta) dehydrogenase 1

Gallus gallus

Rodríguez-Maldonado, E. et al., Nishinaka, T. et al., Sugimoto, Y. et al., Imataka, H. et al., Nishinaka, T. et al., et al.

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High impact information on LOC395641

Expression of 17 beta-hydroxysteroid dehydrogenase type IV in chick retinal pigment epithelium [1].
During the purification procedures, 17 beta-hydroxysteroid dehydrogenase which was present in the cytosol fraction was separated from 5 beta-reductase fraction by the Butyl Toyopearl column chromatography [2].
These results show that theca externa cells from preovulatory follicles of hen have enzymatic activities of 20 beta-reductase (from P5 and P4), 3 beta-hydroxysteroid dehydrogenase/5-4 isomerase (from P5 and DHEA), 17 beta-hydroxysteroid dehydrogenase (from A4 and T), and aromatase (from A4 and T) [3].
The activities of 17 beta-hydroxysteroid dehydrogenase in both gonads were similar to each other, when androstenedione was used as substrate [4].
Activity of 17 beta-hydroxysteroid dehydrogenase (17 beta-HSD) in the ovary was similar to or higher than that in the testis, depending on substrates employed [5].

Biological context of LOC395641

These results indicate that chicken liver estradiol-17 beta dehydrogenase is in fact a 3 beta- and 17 beta-hydroxysteroid dehydrogenase and that both 3- and 17-ketosteroids bind to the same catalytic site [6].

Associations of LOC395641 with chemical compounds

CR1 exhibited 17 beta-hydroxysteroid dehydrogenase activity as well as carbonyl reductase activity in the presence of both NADP(H) and NAD(H) [7].

References

Expression of 17 beta-hydroxysteroid dehydrogenase type IV in chick retinal pigment epithelium. Kobayashi, K., Kobayashi, H., Ueda, M., Honda, Y. Exp. Eye Res. (1997) [Pubmed]
Purification of 5 beta-reductase from hepatic cytosol fraction of chicken. Sugimoto, Y., Yoshida, M., Tamaoki, B. J. Steroid Biochem. Mol. Biol. (1990) [Pubmed]
Steroid metabolism in theca externa cells from preovulatory follicles of domestic hen (Gallus domesticus). Rodríguez-Maldonado, E., Velázquez, P.N., Juárez-Oropeza, M.A., Pedernera, E. Gen. Comp. Endocrinol. (1996) [Pubmed]
Sexual differences of steroidogenic enzymes in embryonic gonads of the chicken (Gallus domesticus). Imataka, H., Suzuki, K., Inano, H., Kohmoto, K., Tamaoki, B. Gen. Comp. Endocrinol. (1988) [Pubmed]
Developmental changes of steroidogenic enzyme activities in the embryonic gonads of the chicken: the sexual difference. Imataka, H., Suzuki, K., Inano, H., Kohmoto, K., Tamaoki, B. Gen. Comp. Endocrinol. (1988) [Pubmed]
3-Keto reductase activity of estradiol-17 beta dehydrogenase and its contribution to androgen metabolism. Nishinaka, T., Kinoshita, Y., Terada, N., Terada, T., Mizoguchi, T., Nishihara, T. J. Pharmacobio-dyn. (1991) [Pubmed]
Characterization of multiple forms of carbonyl reductase from chicken liver. Nishinaka, T., Kinoshita, Y., Terada, N., Terada, T., Mizoguchi, T., Nishihara, T. Enzyme (1992) [Pubmed]

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