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Gene Review

Hsd17b1  -  hydroxysteroid (17-beta) dehydrogenase 1

Mus musculus

Synonyms: 17-beta-HSD 1, 17-beta-hydroxysteroid dehydrogenase type 1, 17HSDB1, 17beta-HSD, E2DH, ...
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Disease relevance of Hsd17b1


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High impact information on Hsd17b1


Biological context of Hsd17b1


Anatomical context of Hsd17b1


Associations of Hsd17b1 with chemical compounds


Other interactions of Hsd17b1


Analytical, diagnostic and therapeutic context of Hsd17b1


  1. Both reductive forms of 17 beta-hydroxysteroid dehydrogenase (types 1 and 3) are expressed during development in the mouse testis. Sha, J., Baker, P., O'Shaughnessy, P.J. Biochem. Biophys. Res. Commun. (1996) [Pubmed]
  2. Type 5 17beta-hydroxysteroid dehydrogenase: its role in the formation of androgens in women. Luu-The, V., Dufort, I., Pelletier, G., Labrie, F. Mol. Cell. Endocrinol. (2001) [Pubmed]
  3. Characterization of the porcine FABGL gene. Jacobs, K., Mattheeuws, M., Van Poucke, M., Van Zeveren, A., Peelman, L.J. Anim. Genet. (2002) [Pubmed]
  4. Abundant type 10 17 beta-hydroxysteroid dehydrogenase in the hippocampus of mouse Alzheimer's disease model. He, X.Y., Wen, G.Y., Merz, G., Lin, D., Yang, Y.Z., Mehta, P., Schulz, H., Yang, S.Y. Brain Res. Mol. Brain Res. (2002) [Pubmed]
  5. Steroidogenesis in rabbit preimplantation embryos. Dickmann, Z., Dey, S.K., Gupta, J.S. Proc. Natl. Acad. Sci. U.S.A. (1975) [Pubmed]
  6. Regulation of the gene for estrogenic 17-ketosteroid reductase lying on chromosome 17cen----q25. Tremblay, Y., Ringler, G.E., Morel, Y., Mohandas, T.K., Labrie, F., Strauss, J.F., Miller, W.L. J. Biol. Chem. (1989) [Pubmed]
  7. Stromal PRs mediate induction of 17beta-hydroxysteroid dehydrogenase type 2 expression in human endometrial epithelium: a paracrine mechanism for inactivation of E2. Yang, S., Fang, Z., Gurates, B., Tamura, M., Miller, J., Ferrer, K., Bulun, S.E. Mol. Endocrinol. (2001) [Pubmed]
  8. Molecular cloning of mouse 17 beta-hydroxysteroid dehydrogenase type 1 and characterization of enzyme activity. Nokelainen, P., Puranen, T., Peltoketo, H., Orava, M., Vihko, P., Vihko, R. Eur. J. Biochem. (1996) [Pubmed]
  9. Structure and activity of the murine type 5 17beta-hydroxysteroid dehydrogenase gene(1). Rheault, P., Charbonneau, A., Luu-The, V. Biochim. Biophys. Acta (1999) [Pubmed]
  10. 17 beta-hydroxysteroid dehydrogenase type XI localizes to human steroidogenic cells. Chai, Z., Brereton, P., Suzuki, T., Sasano, H., Obeyesekere, V., Escher, G., Saffery, R., Fuller, P., Enriquez, C., Krozowski, Z. Endocrinology (2003) [Pubmed]
  11. The gene for 17 beta-hydroxysteroid dehydrogenase maps to human chromosome 17, bands q12-q21, and shows an RFLP with ScaI. Winqvist, R., Peltoketo, H., Isomaa, V., Grzeschik, K.H., Mannermaa, A., Vihko, R. Hum. Genet. (1990) [Pubmed]
  12. Estrogen receptor-alpha gene deficiency enhances androgen biosynthesis in the mouse Leydig cell. Akingbemi, B.T., Ge, R., Rosenfeld, C.S., Newton, L.G., Hardy, D.O., Catterall, J.F., Lubahn, D.B., Korach, K.S., Hardy, M.P. Endocrinology (2003) [Pubmed]
  13. Localization of 17beta-hydroxysteroid dehydrogenase type 1 mRNA in mouse tissues. Pelletier, G., Luu-The, V., Li, S., Ren, L., Labrie, F. J. Mol. Endocrinol. (2004) [Pubmed]
  14. Localization of type 5 17beta-hydroxysteroid dehydrogenase mRNA in mouse tissues as studied by in situ hybridization. Pelletier, G., Luu-The, V., Li, S., Labrie, F. Cell Tissue Res. (2005) [Pubmed]
  15. Localization of type 7 17beta-hydroxysteroid dehydrogenase in mouse tissues. In situ hybridization studies. Pelletier, G., Luu-The, V., Li, S., Labrie, F. J. Steroid Biochem. Mol. Biol. (2005) [Pubmed]
  16. Enzymatic properties of a member (AKR1C20) of the aldo-keto reductase family. Matsumoto, K., Endo, S., Ishikura, S., Matsunaga, T., Tajima, K., El-Kabbani, O., Hara, A. Biol. Pharm. Bull. (2006) [Pubmed]
  17. Molecular characterization of the cynomolgus monkey Macaca fascicularis steroidogenic enzymes belonging to the aldo-keto reductase family. Liu, H., Bellemare, V., Labrie, F., Luu-The, V. J. Steroid Biochem. Mol. Biol. (2007) [Pubmed]
  18. Effects of 3,3',4,4',5-pentachlorobiphenyl, a coplanar polychlorinated biphenyl congener, on cultured neonatal mouse testis. Fukuzawa, N.H., Ohsako, S., Nagano, R., Sakaue, M., Baba, T., Aoki, Y., Tohyama, C. Toxicology in vitro : an international journal published in association with BIBRA. (2003) [Pubmed]
  19. Comparative effects of 28-day treatment with the new anti-estrogen EM-800 and tamoxifen on estrogen-sensitive parameters in intact mice. Luo, S., Martel, C., Sourla, A., Gauthier, S., Mérand, Y., Belanger, A., Labrie, C., Labrie, F. Int. J. Cancer (1997) [Pubmed]
  20. Cellular localization of mRNA expression of enzymes involved in the formation and inactivation of hormonal steroids in the mouse prostate. Pelletier, G., Luu-The, V., Li, S., Ouellet, J., Labrie, F. J. Histochem. Cytochem. (2004) [Pubmed]
  21. Molecular cloning and characterization of mouse estradiol 17 beta-dehydrogenase (A-specific), a member of the aldoketoreductase family. Deyashiki, Y., Ohshima, K., Nakanishi, M., Sato, K., Matsuura, K., Hara, A. J. Biol. Chem. (1995) [Pubmed]
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